A5100586119- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Glycosylation and Glycoproteins Research
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Monoclonal and Polyclonal Antibodies Research
- Viral Infectious Diseases and Gene Expression in Insects
- RNA Interference and Gene Delivery
- Glioma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Antimicrobial Peptides and Activities
- Colorectal Cancer Treatments and Studies
- Nanowire Synthesis and Applications
- Cytokine Signaling Pathways and Interactions
- Biosimilars and Bioanalytical Methods
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Phagocytosis and Immune Regulation
- Air Quality and Health Impacts
- Text and Document Classification Technologies
- Advanced Machining and Optimization Techniques
- Neurological diseases and metabolism
Henan University of Technology
2022-2024
Yulin Orthopedics Hospital of Chinese and Western Medicine
2024
Regend Therapeutics (China)
2022
Jiangsu University
2022
Shanghai Jiao Tong University
2012-2019
Renji Hospital
2012-2019
Shanghai Cancer Institute
2009-2019
State Key Laboratory of Oncogene and Related Genes
2012-2019
University Medical Center
2013
Second Military Medical University
2013
Abstract Despite success in hematologic malignancies, the treatment landscape of chimeric antigen receptor (CAR) T cell therapy for solid tumors remains limited. Claudin18.2 (CLDN18.2)-redirected CAR cells showed promising efficacy against gastric cancer (GC) a preclinical study. Here we report interim analysis results an ongoing, open-label, single-arm, phase 1 clinical trial CLDN18.2-targeted (CT041) patients with previously treated, CLDN18.2-positive digestive system cancers ( NCT03874897...
Abstract Purpose: The aim of our study is to elucidate whether T cells expressing GPC3-targeted chimeric antigen receptor (CAR) can efficiently eliminate GPC3-positive HCC and their potential in the treatment HCC. Experimental Design: a first-generation third-generation CAR were prepared using lentiviral vector transduction. vitro vivo cytotoxic activities genetically engineered evaluated against various cell lines. Results: could kill but not GPC3-negative vitro. These seemed be positively...
Our preclinical studies demonstrated the potential of chimeric antigen receptor (CAR)-glypican-3 (GPC3) T-cell therapy for hepatocellular carcinoma (HCC). We report herein first published results CAR-GPC3 HCC.In two prospective phase I studies, adult patients with advanced GPC3+ HCC (Child-Pugh A) received autologous following cyclophosphamide- and fludarabine-induced lymphodepletion. The primary objective was to assess treatment's safety. Adverse events were graded using Common Terminology...
3049 Background: HCC was commonly diagnosed and identified as leading causes of cancer death in China. Using a 10% cutoff score, GPC3 detected 63.6% HCCs. Safety preliminary efficacy CAR-T evaluated 13 Chinese patients (pts) with r/r GPC3+ Phase I trial. Methods: Pts between 18 70 yrs old histopathological confirmed HCC, Child-Pugh score≤B7, ECOG≤1, lymphocyte ≥ □0.7 x10 9 , post-transduction positive T cells □ ≥30%, amplification by α CD3/CD28 ≥5 □, without ascites HIV infection were...
Abstract The heterogeneous expression of EGFRvIII [variant III mutant epidermal growth factor receptor (EGFR)] in glioblastoma has significant impact on the clinical response to treatment EGFRvIII-specific chimeric antigen receptor–engineered T (CAR T) cells. We hypothesized that CAR cells could target both and form EGFR expressed tumor cells, but not normal would greatly improve efficacy without inducing on-target, off-tumor toxicity. Therefore, we developed a humanized single-chain...
// Kesang Li 1 , Xiaorong Pan Yanyu Bi Wen Xu Cheng Chen Huiping Gao Bizhi Shi Hua Jiang Shengli Yang Liyan 2 Zonghai State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiaotong University School Medicine, Shanghai, China Department Pulmonary Chest Jiao Tong University, Correspondence to: Li, e-mail: Zonghaili@shsmu.edu.cn Keywords: lung squamous cell carcinoma, chimeric antigen receptor, glypican-3, CAR T Received: August 12, 2015 Accepted:...
As a validated therapeutic target in several human cancers, the EGF receptor (EGFR) provides focus to gain deeper insights into cancer pathophysiology. In this study, we report identification of naturally occurring and widely expressed EGFR isoform termed EGFRvA, which substitutes Ser/Thr-rich peptide for part carboxyl-terminal regulatory domain receptor. Intriguingly, EGFRvA expression relates more closely histopathologic grade poor prognosis patients with glioma. Ectopic cells conferred...
Recently, de4 EGFR, a variant of epidermal growth factor receptor (EGFR) with exon 4 deletion, was identified in glioblastoma and ovarian cancer. However, its biological function on cancer is still not clear. In this study, the expression profile EGFR contribution to epithelial cells proliferation, invasiveness drug resistance were studied. Our results showed that 48.6% (35/72) tissues had ratio positively correlated clinical stages. Compared transfectants, transfectants exhibited...
The multikinase inhibitor sorafenib is the first oral agent to show activity against human hepatocellular carcinoma (HCC). Although clinical application of has shown good tolerability in studied populations, it also causes multiple dose-limiting toxicities. Thus, there a strong need reduce overall dose sorafenib. We have reported that epidermal growth factor receptor variant III (EGFRvIII) expression can decrease sensitivity HCC cells chemotherapeutic drugs. Therefore, we sought explore...
In Henan, strawberry cultivation occurs on approximately 10,000 hectares, with annual production approaching 230,000 tons. April 2022, a root rot disease 10% incidence rate was observed the cultivars 'Ningyu' and 'Sweet Charlie' grown in plastic greenhouses (0.7 ha) located Xingyang (113.39°E, 34.79°N), China. Disease symptoms included yellowing of outer mature leaves, stunted growth, subsequent wilting entire plant. The roots developed dark brown spots, which gradually turned necrotic...
Recently, we reported that GPC3-targeted CAR-T cells could eradicate hepatocellular carcinoma xenografts in mice. However, do not know whether on-target off-tumor toxicity, a major toxicity associated with will happen when using these GPC3-CAR T human being. We propose dual-targeted co-expressing GPC3- and ASGR1 (a liver tissue-specific protein)-targeted CAR signal CD3ζ 28BB (containing both CD28 4-1BB signaling domain) respectively might be used to reduce toxicity. first demonstrated GPC3...
A semi-joint user scheduling (semi-JUS) scheme is proposed to improve the performance of advanced version Long Term Evolution, i.e. LTE-Advanced, systems. The system low cost and complex. Carrier aggregation (CA) based LTE-Advanced systems commonly adopt joint (JUS) separated random (SRUS) schemes. former optimal in but with high complexity latter simple less efficient. In our scheme, equipments (UEs) are limited receive transmit from only one component carriers (CCs) at any time, which...
Due to its wide applications, multi-output learning that predicts multiple output values for a single input at the same time is becoming more and attractive. As one of most popular frameworks dealing with learning, performance k-nearest neighbor (kNN) algorithm mainly depends on metric used compute distance between different instances. In this paper, we propose novel cost-weighted geometric mean method learning. Specifically, learns which can make embedding correct be smaller than outputs...
Colorectal cancer (CRC) is a common malignant tumor in the digestive tract, and 30%-85% of CRCs express epidermal growth factor receptors (EGFRs). Recently, treatments using cetuximab, also named C225, an anti-EGFR monoclonal antibody, for CRC have been demonstrated to cause S492R mutation EGFR. However, little known about biological function Therefore, we attempted elucidate its cells explore new treatment strategies this mutant form. Our study indicated that EGFR accelerate vitro vivo...
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