A5058019217- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Histone Deacetylase Inhibitors Research
- Calpain Protease Function and Regulation
- RNA modifications and cancer
- Animal Nutrition and Physiology
- Effects of Environmental Stressors on Livestock
- Protein Degradation and Inhibitors
- Identification and Quantification in Food
- Cancer-related molecular mechanisms research
- Biochemical Acid Research Studies
- Coenzyme Q10 studies and effects
- Cancer Immunotherapy and Biomarkers
- Nanocomposite Films for Food Packaging
- Postharvest Quality and Shelf Life Management
- Nanopore and Nanochannel Transport Studies
- Spectroscopy and Chemometric Analyses
- Viral Infections and Immunology Research
- Heat shock proteins research
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Tryptophan and brain disorders
Soochow University
2024-2025
Gannan Medical University
2023-2025
Peking University Cancer Hospital
2023-2025
First Affiliated Hospital of Zhengzhou University
2025
The Ohio State University
2017-2024
Second Affiliated Hospital of Nanchang University
2018-2024
Nanchang University
2018-2024
Beijing University of Agriculture
2023-2024
Mirna Therapeutics (United States)
2024
Qufu Normal University
2023
Abstract Messenger RNA (mRNA) vaccines are being used to combat the spread of COVID-19 (refs. 1–3 ), but they still exhibit critical limitations caused by mRNA instability and degradation, which major obstacles for storage, distribution efficacy vaccine products 4 . Increasing secondary structure lengthens half-life, which, together with optimal codons, improves protein expression 5 Therefore, a principled design algorithm must optimize both structural stability codon usage. However, owing...
Triple-negative breast cancer (TNBC) is an aggressive disease with a short median time from relapse to death. The increased aggressiveness, drug resistance, relapse, and metastasis are associated the presence of stem cells within tumors. Several cell markers, such as CD24, CD44, CD133, ALDH1, ABCG2, have been reported, but their roles in tumorigenesis remain unclear. Herein, we apply RNA nanotechnology deliver anti-microRNA (miRNA) for TNBC therapy. thermodynamically chemically stable...
An idea drug carrier, with good binding affinity, selectivity, payload capacity, and cellular internalized capability, will greatly improve the efficiency of target delivery. Herein a self-assembled multivalent DNA nanostructure was developed as carrier for efficient targeted The structure similar to that centipede, composed trunk legs: scaffold via hybridization chain reaction (HCR) from two biotinylated hairpin monomers created upon initiation by trigger DNA, legs were aptamers conjugated...
Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over past few decades, significant progress has been made development targeted epigenetic modulators (e.g., inhibitors). However, inhibitors have faced multiple challenges, including limited clinical efficacy, toxicities, lack subtype selectivity, drug resistance. As result, design new degraders) such as PROTACs, molecular glue, hydrophobic tagging (HyT) degraders garnered attention from both...
Long noncoding RNA GAS5 is down-regulated in cardiomyocytes diabetic cardiomyopathy (DCM). Here, we studied the involvement of DCM by analyzing its expression mouse model and cardiac muscle cell line (HL-1 cells). Compared with normal mice, was severely heart tissues mice. overexpression improved function myocardial hypertrophy In addition, NLRP3, caspase-1, Pro-caspase-1, IL-1β IL-18 were increased mice high glucose-treated HL-1 cells, which repressed up-regulation. suppressed caspase-1...
Rubber is a fascinating material in both industry and daily life. The development of elastomeric nanotechnology imperative due to its economic technological potential. By virtue their distinctive physicochemical properties, nucleic acids have been extensively explored science. Phi29 DNA packaging motor contains 3WJ with three angles 97°, 125°, 138°. Here, the rubber-like property RNA architectures was investigated using optical tweezers vivo imaging technologies. 97° interior angle...
mRNA neoantigen cancer vaccine inducing neoantigen-specific T cell responses holds great promise for immunotherapy; however, its clinical translation remains challenging because of suboptimal prediction accuracy and low delivery efficiency, which compromise the in vivo therapeutic efficacy. We present a lipopolyplex (LPP)–formulated encoding tandem neoantigens as regimen. The LPP-formulated vaccines elicited robust CD8 + three syngeneic murine tumor models (CT26, MC38, B16F10) to suppress...
The shift in glucose utilization from oxidative phosphorylation to glycolysis is the hallmark of tumor cells. overexpression ENO1, one key enzymes process, has been identified several cancers, however, its role pancreatic cancer (PC) yet unclear. This study identifies ENO1 as an indispensable factor progression PC. Interestingly, ENO1-knockout could inhibit cell invasion and migration prevent proliferation ductal adenocarcinoma (PDAC) cells (PANC-1 MIA PaCa-2); meanwhile, uptake lactate...
A series of novel PD-L1/HDAC6 dual inhibitors were designed and synthesized, compound HP29 was identified as the most potent candidate, which demonstrated excellent selective HDAC6 inhibitory activity (IC50 = 78 nM, SI > 1282), high anti-PD-1/PD-L1 26.8 nM). Further studies showed that could bind with affinity to PD-L1 protein. Furthermore, possessed favorable in vivo pharmacokinetic properties, such decent oral bioavailability (F 15.3%). Moreover, exhibited significant antitumor efficacy a...
Unleashing T cell function is critical for efficacious cancer immunotherapy. Here, we present an in vivo activation strategy by silencing Casitas B-lineage lymphoma proto-oncogene b (Cbl-b), intracellular checkpoint, to effectively combat solid tumors. The polymersomes are able efficiently load and deliver siRNA against cblb cells both vitro vivo, successfully the gene expression primary enhancing IL-2 receptor CD25 expression, which turn enhances prevents exhaustion. In studies showed that...
Abstract Mitochondria Sirtuins including SIRT4 erase a variety of posttranslational modifications from mitochondria proteins, leading to metabolic reprogramming that acts as tumor suppressor, oncogenic promotor, or both. However, the factors and underlying mechanisms stimulate relay such signaling cascade are poorly understood. Here, we reveal voltage‐gated calcium channel subunit α2δ1‐mediated can upregulate expression SIRT4, which is highly expressed in α2δ1‐positive pancreatic...
We have previously demonstrated that DGLA treatment along with Delta-5-Desaturase (D5D) siRNA in various types of cancer cells enhances the formation 8-HOA from COX-2-catalyzed peroxidation, which turn inhibits cell growth and migration. However, delivery naked remains a formidable challenge due to its "off-target" effect. In this study, we employed RNA nanotechnology for specific D5D-siRNA xenograft colon tumors using 3WJ nanoparticles. When targeting module, i.e., EpCAM aptamer, was...
Background: Cutaneous squamous cell carcinoma (cSCC) is a common cutaneous cancer with increasing incidence. Itraconazole has been identified as potential anticancer drug candidate. However, the role of itraconazole in cSCC was still unclear. Our objective exploring therapeutic and investigate its molecular mechanism. Methods: The anti-proliferation effect tested CCK-8 assay clone formation assay. Cell cycle distribution apoptosis rate were detected using flow cytometry TUNEL assay,...
The mRNA vaccine has demonstrated significant effectiveness in protecting against SARS-CoV-2 during the pandemic, including severe forms of disease caused by emerging variants. In this study, we examined safety, immunogenicity, and relative efficacy a heterologous booster lipopolyplex (LPP)-based (SW-BIC-213) versus homologous an inactivated (BBIBP) Laos.
Many studies have demonstrated that neuroinflammation contributes to the onset and development of Alzheimer’s disease (AD). The infiltration immune cells in brain was observed AD. purpose present study verify potential mechanisms screen out biomarkers related We collected expression profiling datasets AD patients healthy donors from NCBI’s Gene Expression Omnibus (GEO) database. confirmed immune-related were involved using differentially expressed genes analysis functional enrichment...