A5028209679- Silicone and Siloxane Chemistry
- Advanced biosensing and bioanalysis techniques
- Advanced Polymer Synthesis and Characterization
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Luminescence and Fluorescent Materials
- DNA and Nucleic Acid Chemistry
- Surface Modification and Superhydrophobicity
- Block Copolymer Self-Assembly
- Polymer Surface Interaction Studies
- Supramolecular Chemistry and Complexes
- Surface Chemistry and Catalysis
- RNA and protein synthesis mechanisms
- Advanced Sensor and Energy Harvesting Materials
- Chemical Synthesis and Analysis
- Polyoxometalates: Synthesis and Applications
- Pickering emulsions and particle stabilization
- Dyeing and Modifying Textile Fibers
- Synthesis and properties of polymers
- Photochromic and Fluorescence Chemistry
- Cryospheric studies and observations
- Machine Learning in Materials Science
- Molecular Junctions and Nanostructures
- Virology and Viral Diseases
- Monoclonal and Polyclonal Antibodies Research
Soochow University
2025
Peking University
2016-2024
Zhejiang Sci-Tech University
2022-2024
Beijing National Laboratory for Molecular Sciences
2016-2023
Tsinghua University
2010-2023
Gansu Agricultural University
2023
Changchun Institute of Optics, Fine Mechanics and Physics
2023
Chinese Academy of Sciences
2023
University of Chinese Academy of Sciences
2023
Fujian Medical University
2023
Graphical Abstract A supramolecular double network hydrogel is presented by physical interpenetration of DNA and cucurbit[8]uril networks. In addition to exhibiting an increase in strength thermal stability, the possesses excellent properties such as stretchability, ductility, shear-thinning, thixotropy. Moreover, it enzymatically responsive both nuclease cellulase, well small molecules, showing great potential a new soft material scaffold.
Abstract Regeneration after severe spinal cord injury cannot occur naturally in mammals. Transplanting stem cells to the site is a highly promising method, but it faces many challenges because relies heavily on microenvironment provided by both lesion and delivery material. Although mechanical properties, biocompatibility, biodegradability of materials have been extensively explored, their permeability has rarely recognized. Here, DNA hydrogel designed with extremely high repair 2 mm gap...
RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) or short hairpin (shRNAs) has become a powerful tool for gene knockdown studies. However, the levels of vary greatly. Here, we examine effect target disruption energy, novel measure accessibility, along with other parameters that may affect RNAi efficiency. Based on secondary structures predicted Sfold program, energy represents free cost local alteration structure to allow binding siRNA guide strand. In analyses 100 siRNAs...
A polypeptide-DNA hydrogel is prepared by employing the "X"-shaped DNA assembling structure as crosslinker. The can be modified with multifunctional components (here fluorescent molecules a model) and possesses excellent self-healing thixotropic properties, enabling direct-writing of arbitrary 3D structures. This study provides simple, universal strategy for assembly functionalized hydrogels.
Immunotherapy is believed to be an ideal method treat cancer because it can break the immunotolerance of tumor and induce robust immunoresponse. However, constructing a wide antigen-adaptive, easy-handling, biodegradable system that recruit activate antigen-presenting cells (APCs) much effectively still challenge. Herein, we show injectable DNA supramolecular hydrogel vaccine (DSHV) which could efficiently APCs in vitro vivo. The processes have been visualized by fluorescence microscopy....
This work describes the first rigorous example of a single-component block copolymer system forming unconventional spherical phases. A library discrete polymers with uniform chain length and diverse architectures were modularly prepared through combination step-growth approach highly efficient coupling reactions. The precise chemical structure eliminates all molecular defects associated molar weight, dispersity, compositional ratio. Complex phases, including Frank–Kasper phase (A15 σ)...
Abstract Background RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) or short hairpin (shRNAs) has become a powerful technique for eukaryotic gene knockdown. siRNA GC-content negatively correlates with RNAi efficiency, and it is of interest to have convincing mechanistic interpretation this observation. We here examine issue considering the secondary structures both target messenger (mRNA) guide strand. Results By analyzing unique homogeneous data set 101 shRNAs targeted...
By integrating a DNA motor based on an i-motif sequence that undergoes pH-dependent conformational transition into hydrogel network, such microscopic leads to macroscopic change in mechanical properties. This strategy allows reversible tuning of the strength ranging from 250 Pa 1000 Pa.
DNA hydrogel has aroused widespread attention because of its unique properties. In this work, the DNA-modified magnetic nanoparticles were integrated into mainframe hydrogel, resulting in DNA-MNP hydrogel. Under field, can be remotely deformed various shapes, driven to jump between two planes and even climb hill. By applying triggers, such as temperature, enzyme, specifically undergo sol-gel transition. This work not only imparts with a new fold property but also opens platform smart...
Tissue engineering has long been a challenge because of the difficulty addressing requirements that such an engineered tissue must meet. In this paper, we developed new "brick-to-wall" based on unique properties DNA supramolecular hydrogels to fabricate three-dimensional (3D) tissuelike structures: different cell types are encapsulated in hydrogel bricks which then combined build 3D structures. Signal responsiveness cells through gels was evaluated and it discovered gel permits migration 3D....
Mechanical interactions between cells and extracellular matrix (ECM) are critical for stem cell fate decision. Synthetic models of ECM, such as hydrogels, can be used to precisely manipulate the mechanical properties niche investigate how signals regulate behavior. However, it has long been a great challenge tune solely ECM-mimic hydrogels' since altering most materials is usually accompanied by chemical topological changes. Here, we employ DNA its enantiomers prepare series hydrogels with...
This article reports the unique dimeric packing of POSS-PDI-POSS shape amphiphile which has great enhanced photoluminescent properties in crystals compared with more amorphous solid state.
A supramolecular hydrogel with identical cross-linking point density but distinctive rheological properties is developed by adjusting the DNA stability.
Abstract Spiropyran‐based materials (SPBMs) can give responses to the stimulations induced by light, heat, force, or pH, which have been used as triggers for many smart materials. Here, a cross‐linkable SPBM containing mesogenic‐units is synthesized, pale‐colored, non‐photoluminescent and non‐mesogenic at spiro form, but dark‐colored, photoluminescent, mesogenic merocyanine form. Moreover, dynamic interconversion behavior of form in different chemical environments are distinct. Liquid...
The inherent statistical heterogeneities associated with chain length, composition, and architecture of synthetic block copolymers compromise the quantitative interpretation their self-assembly process. This study scrutinizes contribution molecular on phase behaviors using discrete ABA triblock precise chemical structure uniform length. A group varying composition symmetry were modularly synthesized through a combination iterative growth methods efficient coupling reactions. symmetric...
It remains challenging to understand the structural evolution of conjugated polymers from single chains solvated aggregates and film microstructures, although it underpins performance optoelectrical devices fabricated via mainstream solution processing method. With several ensemble visual measurements, here we unravel morphological process a model system isoindigo-based molecules, including hidden molecular assembly pathways, mesoscale network formation, their unorthodox chain dependence....
Multi-station passive localization algorithms based on hybrid Time Difference of Arrival (TDOA) and Angle (AOA) have been thoroughly studied. But it usually requires each station to obtain the AOA source relies precise position. These conditions are generally not satisfied in practical applications. In addition, geometry between these stations also affects accuracy. This paper studies problem multi-station TDOA single-station measurements. First, we propose a closed-form solution method...
Unleashing T cell function is critical for efficacious cancer immunotherapy. Here, we present an in vivo activation strategy by silencing Casitas B-lineage lymphoma proto-oncogene b (Cbl-b), intracellular checkpoint, to effectively combat solid tumors. The polymersomes are able efficiently load and deliver siRNA against cblb cells both vitro vivo, successfully the gene expression primary enhancing IL-2 receptor CD25 expression, which turn enhances prevents exhaustion. In studies showed that...