A5100642931- Alzheimer's disease research and treatments
- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- Biosensors and Analytical Detection
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- interferon and immune responses
- Mass Spectrometry Techniques and Applications
- Click Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Advancements in Battery Materials
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Advanced Battery Materials and Technologies
- Supramolecular Self-Assembly in Materials
- RNA Research and Splicing
- Plant Stress Responses and Tolerance
- Supercapacitor Materials and Fabrication
- Plant Pathogens and Fungal Diseases
- RNA modifications and cancer
- Luminescence and Fluorescent Materials
- Computational Drug Discovery Methods
Tsinghua University
2016-2025
Gansu Agricultural University
2022-2025
Chinese Institute for Brain Research
2016-2025
Beijing Academy of Agricultural and Forestry Sciences
2014-2025
South China University of Technology
2014-2025
Capital Medical University
2013-2025
Beijing YouAn Hospital
2023-2025
Harbin Institute of Technology
2022-2025
Beihang University
2022-2025
Shanxi Normal University
2023-2025
Abstract Background A pandemic is a very stressful event, especially for highly vulnerable people (e.g., older adults). The purpose of the current study was to investigate main and interactive relationships social support resilience on individual mental health during COVID-19 across three age groups: emerging adults, adults. Methods survey conducted with 23,192 participants aged 18–85. Respondents completed questionnaire, including items COVID-19-related they perceived from different...
Significance Posttranslational modifications (PTMs) play an important role in modulating α-syn structure, function, and pathology. Phosphorylation commonly applies to pathological aggregation Lewy bodies is a hallmark of Parkinson’s disease (PD). Here, we obtain homogeneous fibrils formed by semisynthesized with site-specific phosphorylation at Y39. The synthetic fibril recapitulates the neuropathology degradation resistance endogenous pY39 PD. Cryo-EM structure determination reveals fold...
Abstract In contrast to conventional batteries, anode-free configurations can extend cell-level energy densities closer the theoretical limit. However, realizing alkali metal plating/stripping on a bare current collector with high reversibility is challenging, especially at low temperature, as an unstable solid-electrolyte interphase and uncontrolled dendrite growth occur more easily. Here, low-temperature potassium (K) non-aqueous battery reported. By introducing Si-O-based additives,...
Abstract α-Synuclein forms amyloid fibrils that are critical in the progression of Parkinson’s disease and serves as pathological hallmark this condition. Different posttranslational modifications have been identified at multiple sites α-synuclein, influencing its conformation, aggregation function. Here, we investigate how disease-related phosphorylation O-GlcNAcylation same α-synuclein site (S87) affect fibril structure neuropathology. Using semi-synthesis, obtained homogenous monomer with...
In the development of vaccines for epithelial tumors, key targets are MUC1 proteins, which have a variable number tandem repeats (VNTR) bearing tumor-associated carbohydrate antigens (TACAs), such as Tn and STn. A major obstacle in vaccine is low immunogenicity short peptide. To overcome this obstacle, we designed, synthesized, evaluated several totally synthetic self-adjuvanting candidates with self-assembly domains. These aggregated into fibrils displayed multivalent B-cell epitopes under...
An enzyme toolbox was developed for the synthesis of valuable C-6 compounds<italic>via</italic>selective oxidation HMF. A proof-of-concept based on DES provided separation HMF and DFF.
Herein, novel photoactive materials, nitrogen-doped porous carbon-ZnO (NPC-ZnO) nanopolyhedra, were prepared by direct carbonization of zeolitic imidazolate framework (ZIF)-8 nanopolyhedra in a nitrogen atmosphere. The morphology, structure, and photoelectrochemical (PEC) properties characterized scanning electron microscopy, transmission X-ray photoelectron spectroscopy, Raman adsorption–desorption method, PEC methods. results showed that the obtained NPC-ZnO had rhombic dodecahedron...
Abstract Multivalent synthetic vaccines were obtained by solid‐phase synthesis of tumor‐associated MUC1 glycopeptide antigens and their coupling to a Pam 3 Cys lipopeptide through click reactions. These elicited immune responses in mice without the use any external adjuvant. The vaccine containing four copies sialyl‐T N antigen showed significant cluster effect. It induced prevailing IgG 2a antibodies, which bind MCF‐7 breast tumor cells initiate killing these activation complement‐dependent...
The T-helper epitope peptide P30 (green in the scheme) from tetanus toxoid was used as immunostimulant MUC1 glycopeptide antitumor vaccines and apparently also acts a built-in adjuvant. P30-conjugated containing three glycans immunodominant motifs PDTRP GSTAP induced much stronger immune responses complement dependent cytotoxicity mediated killing of tumor cells when applied plain PBS solution without complete Freund's As service to our authors readers, this journal provides supporting...
Catalytic upgrading of 5-hydroxymethylfurfural (HMF), an important biobased platform chemical for high-value products, is currently great interest. In this work, a new highly HMFtolerant yeast strain-Meyerozyma guilliermondii SC1103 was isolated, and biocatalytic reduction HMF to 2,5-bis(hydroxymethyl)furan (BHMF) using its resting cells reported. Cosubstrates exerted significant effect on the catalytic activity selectivity microbial as well their HMF-tolerant levels whereas nitrogen source...
Immunotherapy is believed to be an ideal method treat cancer because it can break the immunotolerance of tumor and induce robust immunoresponse. However, constructing a wide antigen-adaptive, easy-handling, biodegradable system that recruit activate antigen-presenting cells (APCs) much effectively still challenge. Herein, we show injectable DNA supramolecular hydrogel vaccine (DSHV) which could efficiently APCs in vitro vivo. The processes have been visualized by fluorescence microscopy....