A5101582953- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Wound Healing and Treatments
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Polysaccharides and Plant Cell Walls
- Autoimmune Bullous Skin Diseases
- Monoclonal and Polyclonal Antibodies Research
- IL-33, ST2, and ILC Pathways
- Cancer Research and Treatments
- Asthma and respiratory diseases
- Medicinal Plant Pharmacodynamics Research
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Mast cells and histamine
- Diabetes and associated disorders
- Oral Health Pathology and Treatment
- Oral and gingival health research
- Plant Toxicity and Pharmacological Properties
- Cholesterol and Lipid Metabolism
- RNA modifications and cancer
University of Louisville
2012-2024
Peking University
2024
Mirna Therapeutics (United States)
2024
Shenzhen Third People’s Hospital
2022
Shenzhen University
2022
Affiliated Hospital of Southwest Medical University
2017
Ruijin Hospital
2011-2015
Shanghai Jiao Tong University
2009
Abstract Tumor-associated macrophages (TAM) with an alternatively activated phenotype have been linked to tumor-elicited inflammation, immunosuppression, and resistance chemotherapies in cancer, thus representing attractive target for effective cancer immunotherapy. In this study, we demonstrate that particulate yeast-derived β-glucan, a natural polysaccharide compound, converts polarized or immunosuppressive TAM into classically potent immunostimulating activity. This process is associated...
The beneficial properties of β-glucans have been recognized for centuries. Their proposed mechanisms action in cancer therapy occur via stimulation macrophages and priming innate neutrophil complement receptor 3 eliciting 3-dependent cellular cytotoxicity iC3b-opsonized tumor cells. current study is to investigate whether β-glucan has any effect on antitumor adaptive T-cell responses.We first examined the trafficking orally administered particulate yeast-derived its interaction with...
Promoting complement (C) activation may enhance immunological mechanisms of anti-tumor Abs for tumor destruction. However, C components, such as C5a, trigger inflammation, which can promote growth. We addressed the role C5a on growth by transfecting both human carcinoma and murine lymphoma with mouse C5a. In vitro kinetics control vector, or parental cells revealed no significant differences. Tumor-bearing mice C5a-transfected xenografted had significantly less burden compared vector tumors....
Dermal γδT cells play critical roles in skin homeostasis and inflammation. However, the underlying molecular mechanisms by which these are activated have not been fully understood. Here, we show that mechanistic or mammalian target of rapamycin (mTOR) STAT3 pathways dermal response to innate stimuli such as interleukin-1β (IL-1β) IL-23. Although both mTOR complex 1 (mTORC1) mTORC2 essential for cell proliferation, deficiency leads decreased γδT17 cells. It appears mitochondria-mediated...
IL-17-producing γδT cells (γδT17) promote autoinflammatory diseases and cancers. Yet, γδT17 peripheral regulation has not been thoroughly explored especially in the context of microbiota-host interaction. The potent antigen-presenting CD103+ dendritic cell (DC) is a key immune player close contact with both microbiota. This study presents novel cellular network among microbiota, DCs, cells.Immunophenotyping IL-17r-/- mice IRF8-/- were performed by ex vivo immunostaining flow cytometric...
Psoriasis recurrence is a clinically challenging issue. However, the underlying mechanisms haven't been fully understood.RNAseq analysis from affected skin of psoriatic patients treated with topical glucocorticoid (GC) different outcomes was performed. In addition, imiquimod (IMQ)-induced mouse psoriasis-like model used to mimic GC treatment in human psoriasis patients. Skin tissues and draining distant lymph nodes (LNs) were harvested for flow cytometry histology analyses.RNAseq revealed...
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mRNA neoantigen cancer vaccine inducing neoantigen-specific T cell responses holds great promise for immunotherapy; however, its clinical translation remains challenging because of suboptimal prediction accuracy and low delivery efficiency, which compromise the in vivo therapeutic efficacy. We present a lipopolyplex (LPP)–formulated encoding tandem neoantigens as regimen. The LPP-formulated vaccines elicited robust CD8 + three syngeneic murine tumor models (CT26, MC38, B16F10) to suppress...
Cellular metabolism has been proposed to govern distinct γδ T cell effector functions, but the underlying molecular mechanisms remain unclear. We show that interleukin-17 (IL-17)-producing (γδT17) and interferon-γ (IFN-γ)-producing (γδT1) cells have differential metabolic requirements rate-limiting enzyme isocitrate dehydrogenase 2 (IDH2) acts as a checkpoint for their functions. Intriguingly, transcription factor c-Maf regulates γδT17 function through direct regulation of IDH2 promoter...
Innate γδ T cells play critical roles in mucosal immunity such as regulating intestinal epithelial homeostasis. In addition, are significantly increased the inflamed mucosa of patients with ulcerative colitis. However, a heterogeneous population. IL-17-producing versus IFNγ-producing differential different disease settings. Therefore, dissecting exact role subsets colitis is essential for understanding immunopathogenesis. current study, we found that TCR δ-deficient mice had more severe...
Aims To investigate antiatherosclerosis effect of atorvastatin (ATV) in a rat atherosclerosis model, and to explore roles nitric oxide hydrogen sulfide (H2S) this event. Methods After being fed high-fat diet, the rats were treated with ATV, ATV combined cystathionine-γ-lyase (CSE) inhibitor DL-propargylglycine, endothelial synthase (eNOS) N’-nitro-L-arginine-methyl ester hydrochloride from 9 12 weeks, respectively. At end experiment, animals sacrificed. Pathologic changes aortic arch...
Abstract This study was undertaken to determine the role of secreted frizzled‐related protein 5 (SFRP5) in endothelial oxidative injury. Human aortic cells (HAECs) were exposed different stimuli and examined for SFRP5 expression. The effects overexpression knockdown on cell viability, apoptosis, reactive oxygen species production measured. HAECs treated with angiotensin (Ang) II (1 μM) or oxidized low‐density lipoprotein (oxLDL) (150 μg/mL) showed a significant increase Overexpression...
Natural IL-17-producing γδ T cells (γδT17 cells) are unconventional innate-like that undergo functional programming in the fetal thymus. However, intrinsic metabolic mechanisms of γδT17 cell development remain undefined. Here, we demonstrate mTORC2, not mTORC1, selectively controls fate commitment through regulating transcription factor c-Maf expression. scRNA-seq data suggest and adult predominately utilize mitochondrial metabolism. mTORC2 deficiency results impaired Drp1-mediated fission...