A5100445552- Immune cells in cancer
- Immune Cell Function and Interaction
- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- Advancements in Battery Materials
- Advanced Battery Technologies Research
- Reproductive System and Pregnancy
- Advanced Battery Materials and Technologies
- Gut microbiota and health
- Cardiac, Anesthesia and Surgical Outcomes
- Single-cell and spatial transcriptomics
- Psoriasis: Treatment and Pathogenesis
- Epigenetics and DNA Methylation
- Adenosine and Purinergic Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Acute Kidney Injury Research
- Cholesterol and Lipid Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Dialysis and Renal Disease Management
- Bioactive Compounds and Antitumor Agents
Third Xiangya Hospital
2025
Central South University
2025
Air Force Medical University
2024
Shandong University of Traditional Chinese Medicine
2022-2024
Jiujiang Maternal and Child Care Centres
2024
Xuzhou Medical College
2023
Second People’s Hospital of Huai’an
2023
Huaian First People’s Hospital
2023
Dalian Medical University
2023
Henan University
2022
Tumor-associated macrophages (TAMs) can influence ovarian cancer growth, migration, and metastasis, but the detailed mechanisms underlying metastasis remain unclear. Here, we have shown a strong correlation between TAM-associated spheroids clinical pathology of cancer. Further, determined that TAMs promote spheroid formation tumor growth at early stages transcoelomic in an established mouse model for epithelial M2 macrophage-like were localized center secreted EGF, which upregulated αMβ2...
Myeloid-derived suppressor cells (MDSCs) are immune suppressive that hallmarks of human cancer. MDSCs inhibit cytotoxic T lymphocytes (CTLs) and NK cell functions to promote tumor escape progression, therefore considered key targets in cancer immunotherapy. Recent studies determined a role the apoptosis pathways tumor-induced MDSC homeostasis it is known ceramide plays regulation mammalian apoptosis. In this study, we aimed determine efficacy underlying molecular mechanism suppression MDSCs....
Polarized macrophages can be broadly classified into classically activated (M1) and alternatively (M2) in response to the microenvironment signals. Interferon regulatory factor 1 (IRF1) has been demonstrated play a critical role macrophage polarization. However, mechanisms underlying regulation of IRF1 expression polarization still remain unclear. In this study, was significantly increased interferon-γ (IFN-γ) lipopolysaccharide (LPS)-treated RAW264.7 cells. Moreover, miR-130b-3p decreased...
Recurrent spontaneous abortion (RSA) is a relevant complication of pregnancy. Aberrant dendritic cell (DC) activities and differentiation have been identified to be involved in RSA, but the underlying mechanisms remain unclear. Baicalin from Radix Scutellariae possesses wide range pharmacological biological activities. However, effect baicalin on DC function RSA has not investigated. Here, we analyzed changes peripheral maternal-fetal interface subsets patients mice with respectively. Then,...
We have recently reported that tumor-associated macrophages (TAMs) promote early transcoelomic metastasis of ovarian cancer by facilitating TAM-ovarian cell spheroid formation. ASK1 is known to be important for macrophage activation and inflammation-mediated tumorigenesis. In the present study, we show deficiency attenuates TAM-spheroid formation progression in an orthotopic model. Interestingly, stroma, but not TAMs, critical peritoneal tumor growth cancer. Moreover, overexpression...
Abstract Our and other researchers’ previous studies found that myeloid-derived suppressor cells (MDSCs) were increased, these MDSCs, supposed to play immunosuppressive roles, showed significant pro-inflammatory effects in Sjögren’s syndrome (SS). However, the key factors potential mechanisms leading MDSCs be inflammatory remain unclear. In this study, we from SS patients positively correlated with percentages of Th17 cells, disease activity serum autoantibodies, higher levels Fc gamma...
Objectives To evaluate the feasibility of dose-modulated retrospective ECG-gated thoracoabdominal aorta CT angiography (CTA) assessing abdominal aortic intimal flap motion and investigate characteristics in acute dissection (AAD). Materials Methods 49 patients who had CTA scan were enrolled. 20 datasets reconstructed 5% steps between 0 95% R-R interval each case. The was assessed by measuring short axis diameters true lumen false 2 cm above celiac trunk ostium different intervals. Intimal...
Prediabetes is a critical stage characterized by insulin resistance. Morus nigra L., an edible plant, widely used in food and nutritive supplements exhibits various pharmacological activities; however, its therapeutic effects mechanisms on prediabetes have rarely been reported. In this research, the major components of total flavonoids M. L. (TFM) were identified, TFM treatment was found to reduce progressing type 2 diabetes mellitus (T2DM) from 93.75 18.75%. The microbiota next-generation...
ABSTRACT Growing evidence have indicated the crucial role of intratumor microbiome in a variety solid tumor. However, intratumoral gynecological malignancies is largely unknown. In present study, total 90 Han patients, including 30 patients with cancer cervix, ovary, and endometrium each were enrolled, composition was assessed by 16S rDNA amplicon high throughput sequencing. We found that diversity metabolic potential all three types very similar. Furthermore, shared few taxa collectively...
High-grade serous ovarian carcinoma (HGSOC) is one of the most lethal gynecological cancer. Genetic studies have revealed gene copy number alterations (CNAs) frequently occurred in HGSOC pathogenesis, however function and mechanism CNAs for microRNAs are still not fully understood. Here, we show dependence on amplification MIR937 that enhances cell autophagy dictates proliferative activity. Data mining TCGA database correlated with increased expression proliferation HGSOC. Deletion cells led...
Optimal T-cell activation requires both an antigen-specific and a costimulatory signal. CD167 is tyrosine kinase receptor for native type I collagen, its physiologic functions include matrix homeostasis cell growth, adhesion, branching, migration, but the specific role of in T cells has not yet been characterized. In this study, we found that expression on was up-regulated after activation. Cooperation engagement with suboptimal TCR/CD3 signals induced proliferation, enhanced markers such as...
Cervical cancer (CC) is one of the most prevalent gynecological malignancies. The rate mortality and morbidity among patients with CC high. Cellular senescence involved in tumorigenesis as well progression. However, involvement cellular development still unclear requires further investigation. In this study, we retrieved data on senescence-related genes (CSRGs) from "CellAge" Database. We used TCGA-CESC CGCI-HTMCP-CC datasets training validation sets, respectively. Finally, a signature was...
C-type lectin Ocilrp2/Clec2i is widely expressed in dendritic cells, lymphokine-activated killer cells and activated T cells. Previous studies have shown that Ocilrp2 an important regulator the activation of NK However, role inflammatory responses by macrophages currently unknown. This study investigated expression cytokines LPS-induced from primary peritoneal silenced specific siRNA target Ocilrp2. was significantly downregulated via NF-κB pathways upon LPS stimuli or VSV infection....
Abstract Cervical cancer (CC) is among the most prevalent gynaecological malignancy. The rate of mortality and morbidity patients with CC high. Cellular senescence involved in tumorigenesis as well progression. However, involvement cellular development still unclear requires further investigation. We retrieved data on senescence-related genes (CSRGs) from “CellAge” Database. used TCGA-CESC CGCI-HTMCP-CC datasets training validation sets, respectively. Eight CSRGs signatures based extracted...