A5101964953- Nonlinear Photonic Systems
- Nonlinear Waves and Solitons
- Tannin, Tannase and Anticancer Activities
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Fractional Differential Equations Solutions
- Cell death mechanisms and regulation
- Blood Pressure and Hypertension Studies
- Cold Atom Physics and Bose-Einstein Condensates
- Strong Light-Matter Interactions
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Plant-derived Lignans Synthesis and Bioactivity
- Nutritional Studies and Diet
- Fungal Biology and Applications
- Cancer Mechanisms and Therapy
- Silymarin and Mushroom Poisoning
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Liver physiology and pathology
- Obesity, Physical Activity, Diet
- Cancer therapeutics and mechanisms
- Congenital heart defects research
- PI3K/AKT/mTOR signaling in cancer
- Advanced Fiber Laser Technologies
- Cancer Immunotherapy and Biomarkers
China Pharmaceutical University
2017-2025
Shenzhen Technology University
2021-2025
Wuhan Textile University
2024
Chinese University of Hong Kong
2007-2023
State Key Laboratory of Natural Medicine
2017-2023
Zhejiang University
2011-2023
Beihang University
2021-2023
Changsha University of Science and Technology
2023
Nanchang Institute of Science & Technology
2022
Nanchang University
2022
Abstract Arabidopsis genome expression pattern changes in response to phosphate (Pi) starvation were examined during a 3-d period after removal of Pi from the growth medium. Available concentration was decreased first 24 h roots by about 22%, followed slow recovery 2nd and 3rd d starvation, but no significant change observed leaves within 3 starvation. Microarray analysis revealed that more than 1,800 6,172 genes present array regulated 2-fold or 72 onset Analysis these starvation-responsive...
Summary We generated T‐DNA insertions throughout the rice genome for saturation mutagenesis. More than 1000 flanking sequences were mapped on 12 chromosomes. Our results showed that tags not randomly spread chromosomes and preferentially inserted in gene‐rich regions. Few (2.4%) found repetitive genic (58.1%) intergenic regions (41.9%) a good correlation with predicted size distribution of these genome. Whereas, obvious biases 5′‐ 3′‐regulatory outside coding both at 500‐bp introns rather...
Background— Notch signaling in vascular smooth muscle precursors is required for differentiation. Jagged1 expression on endothelium activates including those of neural crest origin to initiate the formation a layer maturing blood vessel. Methods and Results— Here, we show that direct target muscle, resulting positive feedback loop lateral induction propagates wave differentiation during aortic arch artery development. In vivo, inhibition cardiac impairs messenger RNA results deficient...
Making cardiomyocytes In the heart, multiple cell types work together. Cardiac progenitor cells give rise to cardiomyocyte, endothelial, or smooth muscle lineages. However, identity of a marker specific cardiomyocyte formation has been elusive. Jain et al. now identify specialized population that is committed exclusively forming cardiomyocytes. They also niche signals promote lineage commitment and mechanisms involved in making The findings may help development future cell-based regenerative...
Ischemic heart disease resulting from myocardial infarction (MI) is the most prevalent form of in United States. Post-MI cardiac remodeling a multifaceted process that includes activation fibroblasts and complex immune response. T-regulatory cells (Tregs), subset CD4+ T cells, have been shown to suppress innate adaptive response limit deleterious following injury. However, mechanisms by which injured myocardium recruits suppressive remain largely unknown. Here, we role for Hippo signaling...
<i>Background:</i> Imperatorin (IM) is a furanocoumarin isolated from the root of <i>Angelica dahurica,</i> which reported to have anticonvulsant and anticancer effects. In this study, antiproliferative effect IM on 9 human cancer cell lines was examined, hepatoma HepG2 cells were chosen as target for preferential killing by IM. Particularly, mechanism IM-induced apoptosis in vivo animal effects also studied. <i>Methods:</i> Cell viability measured using...
The Fas-FasL effector mechanism plays a key role in cancer immune surveillance by host T cells, but metastatic human colon carcinoma often uses silencing Fas expression as of evasion. molecular under FAS transcriptional is unknown. We performed genome-wide chromatin immunoprecipitation sequencing analysis and identified that the promoter enriched with H3K9me3 cells. level region significantly higher than primary it inversely correlated level. discovered verticillin A selective inhibitor...
Abstract We investigate oscillatory soliton pairs including the bright-bright solitons, dark-dark bright-dark solitons and beating (beating refers to a type of characterized by components that are each composed both bright dark overall density is equivalent single soliton) in spin-orbit coupled spin-1/2 Bose-Einstein condensates (BECs). Two important effects spin orbit coupling (SOC) Raman detuning resonance on these studied. The results show intensity SOC affects spatial oscillation while...
Cardiomyocyte proliferation is high in early development and decreases progressively with gestation, resulting the lack of a robust cardiomyocyte proliferative response adult heart after injury. Little understood about how both cell-autonomous nonautonomous signals are integrated to regulate balance during development. In this study, we show that single transcription factor, Foxp1, can control by targeting different pathways endocardium myocardium. Endocardial loss Foxp1 results decreased...
The temporal and spatial control of organ-specific endoderm progenitor development is poorly understood. miRNAs affect cell function by regulating programmatic changes in protein expression levels. We show that the miR302/367 cluster a target transcription factor Gata6 mouse lung regulates multiple aspects early development. expressed at stages development, but its levels decline rapidly as proceeds. Gain- loss-of-function studies altering disrupts balance proliferation differentiation, well...
Myeloid-derived suppressor cells (MDSCs) are immune suppressive that hallmarks of human cancer. MDSCs inhibit cytotoxic T lymphocytes (CTLs) and NK cell functions to promote tumor escape progression, therefore considered key targets in cancer immunotherapy. Recent studies determined a role the apoptosis pathways tumor-induced MDSC homeostasis it is known ceramide plays regulation mammalian apoptosis. In this study, we aimed determine efficacy underlying molecular mechanism suppression MDSCs....
Abstract IFN regulatory factor 8 (IRF8) is a key transcription for myeloid cell differentiation and its expression frequently lost in hematopoietic cells of human leukemia patients. IRF8-deficient mice exhibit uncontrolled clonal expansion undifferentiated that can progress to fatal blast crisis, thereby resembling chronic myelogeneous (CML). Therefore, IRF8 suppressor. Whereas the understanding function CML has recently improved, molecular mechanisms underlying are still largely unknown. In...