A5016580028- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Hormonal Regulation and Hypertension
- Cancer Research and Treatments
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Cell death mechanisms and regulation
- Epigenetics and DNA Methylation
- Tannin, Tannase and Anticancer Activities
- RNA modifications and cancer
- interferon and immune responses
- Cancer Mechanisms and Therapy
- Histone Deacetylase Inhibitors Research
- Gastric Cancer Management and Outcomes
- Inflammation biomarkers and pathways
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Pancreatic and Hepatic Oncology Research
- T-cell and B-cell Immunology
- NF-κB Signaling Pathways
- Cancer Cells and Metastasis
Augusta University
2016-2025
Charlie Norwood VA Medical Center
2016-2025
Guizhou University
2024
Nanjing University of Chinese Medicine
2023-2024
University of South China
2024
Beijing Friendship Hospital
2024
Capital Medical University
2024
National Cancer Center of Georgia
2017-2024
Dalian Maritime University
2024
Wilmington University
2024
Summary: PowerMarker delivers a data-driven, integrated analysis environment (IAE) for genetic data. The IAE integrates data management, and visualization in user-friendly graphical user interface. It accelerates the lifecycle enables users to maintain integrity throughout process. An ever-growing list of more than 50 different statistical analyses markers has been implemented PowerMarker. Availability:www.powermarker.net Contact:powermarker@hotmail.com
The A2A adenosine receptor (A2AR) has been shown to be a critical and nonredundant negative regulator of immune cells in protecting normal tissues from inflammatory damage. We hypothesized that A2AR also protects cancerous by inhibiting incoming antitumor T lymphocytes. Here we confirm this hypothesis showing genetic deletion the host resulted rejection established immunogenic tumors approximately 60% A2AR-deficient mice with no observed control WT mice. use antagonists, including caffeine,...
Abstract Short-chain fatty acids, generated in colon by bacterial fermentation of dietary fiber, protect against colorectal cancer and inflammatory bowel disease. Among these metabolites, butyrate is biologically most relevant. GPR109A a G-protein–coupled receptor for nicotinate but recognizes with low affinity. Millimolar concentrations are needed to activate the receptor. Although colonic lumen sufficient maximally, there have been no reports on expression/function this tissue. Here we...
Abstract CD8+ CTL play important roles against malignancy in both active and passive immunotherapy. Nonetheless, the success of antitumor responses may be improved by additional therapeutic modalities. Radiotherapy, which has a long-standing use treating neoplastic disease, been found to induce unique biologic alterations cancer cells affecting Fas gene expression, which, consequently, influence overall lytic efficiency CTL. Here, mouse adenocarcinoma cell model, we examined whether exposure...
Myeloid-derived suppressor cells (MDSCs) comprise immature myeloid populations produced in diverse pathologies, including neoplasia. Because MDSCs can impair antitumor immunity, these have emerged as a significant barrier to cancer therapy. Although much research has focused on how promote tumor progression, it remains unclear develop and why the MDSC response is heavily granulocytic. Given that are manifestation of aberrant myelopoiesis, we hypothesized arise from perturbations regulation...
The usefulness and efficacy of cisplatin, a chemotherapeutic drug, are limited by its toxicity to normal tissues organs, including the kidneys. uptake cisplatin in renal tubular cells is high, leading accumulation cell injury death, culminating acute failure. While extensive investigations have been focused on signaling pathways nephrotoxicity, much less known about mechanism tissues. In this regard, evidence has shown for involvement organic cation transporters (OCT), specifically OCT2....
Despite breakthroughs in immune checkpoint inhibitor (ICI) immunotherapy, not all human cancers respond to ICI immunotherapy and a large fraction of patients with the responsive types do current immunotherapy. This clinical conundrum suggests that additional checkpoints exist. We report here interferon regulatory factor 8 (IRF8) deficiency led impairment cytotoxic T lymphocyte (CTL) activation allograft tumor tolerance. However, analysis chimera mice competitive reconstitution WT IRF8-KO...
Butyrate, an intestinal microbiota metabolite of dietary fiber, has been shown to exhibit protective effects toward inflammatory diseases such as ulcerative colitis (UC) and inflammation-mediated colorectal cancer. Recent studies have that chronic IFN-γ signaling plays essential role in cancer development vivo, whereas genome-wide association linked human UC risk loci IFNG, the gene encodes IFN-γ. However, molecular mechanisms underlying butyrate-IFN-γ-colonic inflammation axis are not well...
Colorectal cancer (CRC) develops through a multistage process that results from the progressive accumulation of genetic mutations, and frequently as result mutations in Wnt signaling pathway. However, it has become evident over past two decades epigenetic alterations chromatin, particularly chromatin components promoter regions tumor suppressors oncogenes, play key roles CRC pathogenesis. Epigenetic regulation is organized at multiple levels, involving primarily DNA methylation selective...
Pancreatic cancer is one of the cancers where anti-PD-L1/PD-1 immunotherapy has been unsuccessful. What confers pancreatic resistance to checkpoint unknown. The aim this study elucidate underlying mechanism PD-L1 expression regulation in context immune evasion.Pancreatic mouse models and human specimens were used determine PD-1 evasion. Histone methyltransferase inhibitors, RNAi, overexpression molecular regulation. All statistical tests two-sided.PD-L1 expressed 60% 90% tumor cells...
Programmed death-ligand 1 (PD-L1) is an inhibitory ligand that binds to PD-1 suppress T cell activation. PD-L1 constitutively expressed and inducible in tumor cells, but the expression profiles regulatory mechanism of myeloid-derived suppressor cells (MDSCs) are largely unknown. We report abundantly tumor-infiltrating leukocytes human patients with both microsatellite instable stable colon cancer. About 60% CD11b+CD33+HLA-DR− MDSCs from peripheral blood cancer PD-L1+. PD-L1+ also...
Abstract Here we show that iNOS-deficient mice display enhanced classically activated M1 macrophage polarization without major effects on alternatively M2 macrophages. eNOS and nNOS mutant comparable compared with wild-type control mice. Addition of N6-(1-iminoethyl)-L-lysine dihydrochloride, an iNOS inhibitor, significantly enhances while S-nitroso-N-acetylpenicillamine, a NO donor, suppresses polarization. derived from mediates nitration tyrosine residues in IRF5 protein, leading to the...
The cellular and molecular mechanisms underlying tumor cell PD-L1 (tPD-L1) function in immune evasion are incompletely understood. We report here that tPD-L1 does not suppress cytotoxic T lymphocyte (CTL) activity co-cultures of cells tumor-specific CTLs exhibits no effect on primary growth. However, deleting decreases lung metastasis a CTL-dependent manner tumor-bearing mice. Depletion myeloid or knocking out PD-1 (mPD-1) impairs promotion Single-cell RNA sequencing (scRNA-seq) reveals...
Arbuscular mycorrhizal fungi (AMF) can penetrate plant root cortical cells, establish a symbiosis with most land species, and form branched structures (known as arbuscules) for nutrient exchange. Plants have evolved complete plant–AMF system to sustain their growth development under various types of abiotic stress. Here, we highlight recent studies AM the regulation process. The roles host interactions in enhancing drought resistance, increasing mineral uptake, regulating hormone synthesis,...
Capacity for cellular replication is critically important lymphocyte function and can be regulated by telomerase-dependent maintenance of telomere length. In contrast to most normal human somatic cells that do not express telomerase due the failure transcribe reverse transcriptase (hTERT), lymphocytes in a highly fashion yet constitutively hTERT during development activation. Here, we report protein present both thymocytes blood T at equivalent levels despite their substantial differences...
Human telomerase consists of two essential components, RNA template (hTER) and reverse transcriptase (hTERT), functions to synthesize telomere repeats that serve protect the integrity chromosomes prolong replicative life span cells. Telomerase activity is expressed selectively in germ-line malignant tumor cells but not most normal human somatic As a notable exception, lymphocytes during development, differentiation, activation. Recent studies have suggested regulation determined by...
Generation of CD8(+) memory T cells requires antigenic stimulation through cell receptor (TCR); however, maintenance seems to be mediated by cytokines, such as IL-15, in a TCR-independent manner. Compared with the TCR-induced activation, less is known about mechanisms IL-15 action. We report here comparative and kinetic analysis responses phenotype or TCR (anti-CD3) vitro. These two stimuli induce highly similar measured cellular proliferation, gene expression changes, synthesis effector...
Cell migration is a critical step in cancer cell invasion. Recent studies have implicated the importance of extracellular signal-regulated kinase (ERK) signaling pathway migration. However, mechanism associated with ERK-regulated poorly understood. Using panel breast lines, we detected an excellent correlation between ERK activity and Interestingly, noticed that 48-hour treatment U0126 [specific mitogen-activated protein/ERK (MEK)-1/2 inhibitor] was needed to significantly inhibit migration,...
A pathogenic role of p53 in AKI was suggested a decade ago but remains controversial. Indeed, recent work indicates that inhibition protects against ischemic rats exacerbates mice. One intriguing possibility is has cell type-specific roles AKI. To determine the tubular p53, we generated two conditional gene knockout mouse models, which specifically ablated from proximal tubules or other segments, including distal tubules, loops Henle, and medullary collecting ducts. Proximal tubule...
Human pancreatic cancer does not respond to immune check point blockade immunotherapy. One key feature of is the association between its progression and chronic inflammation. Emerging evidence supports a role for JAK-STAT pathway in We aimed at testing hypothesis that sustained signaling suppresses cytotoxic T lymphocyte (CTL) activation counteract anti-PD-1 immunotherapy-induced CTL activity cancer. show human carcinomas express high level PD-L1 exhibit low infiltration. inhibitor...
In recent years, immune-based therapies have become an increasingly attractive treatment option for patients with cancer. Cancer immunotherapy is often used in combination conventional chemotherapy synergistic effects. The alkylating agent cyclophosphamide (CTX) has been included various chemoimmunotherapy regimens because of its well-known immunostimulatory Paradoxically, can also induce suppressor cells that inhibit immune responses. However, the identity and biologic relevance these are...
Abstract Composition of the gut microbiota has profound effects on intestinal carcinogenesis. Diet and host genetics play critical roles in shaping composition microbiota. Whether diet genes interact with each other to bring specific changes that affect carcinogenesis is unknown. Ability dietary fibre specifically increase beneficial at expense pathogenic bacteria vivo via unknown mechanism an important process suppresses inflammation Free fatty acid receptor 2 (FFAR2 or GPR43) a for...