A5086225613- Epilepsy research and treatment
- Urinary and Genital Oncology Studies
- Phagocytosis and Immune Regulation
- Functional Brain Connectivity Studies
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Kidney Stones and Urolithiasis Treatments
- Neuroscience and Neuropharmacology Research
- Immune cells in cancer
- Renal Diseases and Glomerulopathies
- Immunotherapy and Immune Responses
- Iron Metabolism and Disorders
- Immune Cell Function and Interaction
- Retinal Diseases and Treatments
- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Urologic and reproductive health conditions
- Neonatal and fetal brain pathology
- Renin-Angiotensin System Studies
- Advanced Neuroimaging Techniques and Applications
- Amoebic Infections and Treatments
- Bladder and Urothelial Cancer Treatments
- Pharmacological Effects and Toxicity Studies
- Neurobiology of Language and Bilingualism
Indian Institute of Technology Delhi
2020-2024
All India Institute of Medical Sciences Raipur
2020-2024
All India Institute of Medical Sciences
2014-2024
Max Super Speciality Hospital
2024
Post Graduate Institute of Medical Education and Research
2020-2024
All India Institute of Medical Sciences Bhopal
2020-2024
Albert Einstein College of Medicine
2023
Thomas Jefferson University
2020-2021
Institute of Post Graduate Medical Education and Research
2021
Washington University in St. Louis
2016-2020
Significance Metabolic stress potently modifies immunity. Recently our laboratory identified the kinase GCN2 as a key modulator of macrophage responses to toll-like receptor ligands; however, role myeloid signals in sterile inflammation and homeostatic tolerance is not known. In this study, we tested requirement for apoptotic cells prevention autoimmunity model lupus. Our results show that critical effector cell-driven required regulatory cytokine production inflammatory Moreover, data...
Abstract Composition of the gut microbiota has profound effects on intestinal carcinogenesis. Diet and host genetics play critical roles in shaping composition microbiota. Whether diet genes interact with each other to bring specific changes that affect carcinogenesis is unknown. Ability dietary fibre specifically increase beneficial at expense pathogenic bacteria vivo via unknown mechanism an important process suppresses inflammation Free fatty acid receptor 2 (FFAR2 or GPR43) a for...
Tolerance to apoptotic cells is essential prevent inflammatory pathology. Though innate responses are critical for immune suppression, our understanding of early immunity driven by apoptosis lacking. Herein we report induce expression the chemokine CCL22 in splenic metallophillic macrophages, which tolerance. Systemic challenge with induced rapid production CD169(+) (metallophillic) resulting accumulation and activation FoxP3(+) Tregs CD11c(+) dendritic cells, an effect that could be...
Diabetic retinopathy (DR) is a leading cause of blindness among working-age adults. Increased iron accumulation associated with several degenerative diseases. However, there are no reports on the status retinal or its implications in pathogenesis DR. In present study, we found that retinas type-1 and type-2 mouse models diabetes have increased compared to non-diabetic retinas. We similar postmortem samples from human diabetic patients. Further, induced HFE knockout (KO) mice model genetic...
Tuberculosis (TB) pleural disease is complicated by extensive tissue destruction. Matrix metalloproteinase (MMP)-1 and -9 are implicated in immunopathology of pulmonary central nervous system TB. There few data on MMP activity TB pleurisy. The present study investigated MMP-1, -2 their specific inhibitors (tissue inhibitor (TIMP)-1 -2) tuberculous effusions, correlated these with clinical histopathological features. Clinical data, routine blood tests, fluid/biopsy material were obtained from...
Inflammatory kidney disease is a major clinical problem that can result in end-stage renal failure. In this article, we show Ab-mediated inflammatory injury and mouse nephrotoxic serum nephritis model was inhibited by amino acid metabolism protective autophagic response. The metabolic signal driven IFN-γ-mediated induction of indoleamine 2,3-dioxygenase 1 (IDO1) enzyme activity with subsequent activation stress response dependent on the eIF2α kinase general control nonderepressible 2 (GCN2)....
<i>Purpose:</i> To assess the outcome of a pediatric population operated for drug-resistant epilepsy from large tertiary care center in India. <i>Methods:</i> Retrospectively: quality life (QOL); prospectively: preoperative assessment included interictal EEG, MRI (as per protocol), video-EEG. Ictal SPECT (with subtraction) and PET were performed when required. QOL scores assessed using HASS or SSQ seizure severity, Quality Life Childhood Epilepsy (QOLCE) QOL, Child...
Humoral responses to nonproteinaceous Ags (i.e., T cell independent [TI]) are a key component of the early response bacterial and viral infection critical driver systemic autoimmunity. However, mechanisms that regulate TI humoral immunity poorly defined. In this study, we report B cell-intrinsic induction tryptophan-catabolizing enzyme IDO1 is mechanism limiting Ab responses. When Ido1(-/-) mice were immunized with Ags, there was significant increase in titers formation extrafollicular...
Diabetic nephropathy (DN) is the most common cause of end-stage renal disease associated with high mortality worldwide. Increases in iron levels have been reported diabetic rat kidneys as well human urine patients diabetes. In addition, a low-iron diet or chelators delay progression DN diabetes and animal models Possible maladaptive mechanisms organ damage by tissue accumulation not studied. We recently that induced retinal renin-angiotensin system (RAS) accelerated retinopathy. However,...
Abstract Accumulating evidence strongly implicates iron in the pathogenesis of aging and disease. Iron levels have been found to increase with age both human mouse retinas. We others shown that retinal diseases such as age-related macular degeneration diabetic retinopathy are associated disrupted homeostasis, resulting accumulation. In addition, hereditary disorders due mutation one regulatory genes lead dependent overload degeneration. However, our knowledge on whether toxicity contributes...
We postulated that prostaglandin E2 (PGE2), which exhibits regulatory functions to control immune-mediated inflammation, fibrosis, oxidative stress, and tissue/cellular regeneration, has the potential improve course of nephritis. Therefore, therapeutic prostanoid on established nephritis in mice was evaluated focusing its role renal cellular recovery, with emphasis cytoprotecting growth-promoting effects. Acute induced by single injection nephrotoxic serum (NTS), followed PGE2 administration...
Background Mobility impairment is common in older persons with multiple sclerosis (MS), and further compounded by general age-related mobility decline but its underlying brain substrates are poorly understood. Objective Examine fronto-striatal white matter (WM) integrity lesion load as imaging correlates of outcomes without MS. Methods Fifty-one MS patients (age 64.9 ± 3.7 years, 29 women) 50 healthy, matched controls (66.2 3.2 24 women), participated the study, which included physical...
Background: Hemispherotomy (HS) is an effective treatment for unilateral hemispheric onset epilepsy. There are few publications HS in adults, and there no series comparing adults pediatric patients of HS. Objective: To compare the hemispherotomies done adult with ones terms efficacy safety. Methods: Data was prospectively collected (up to 18 years more) from Aug 2014 2018. Comparison between groups made seizure onset, duration epilepsy, frequency seizures, number drugs, intraoperative blood...
Functional magnetic resonance imaging (fMRI), a non-invasive technique with high spatial resolution and blood oxygen level dependent (BOLD) contrast, has been applied to localize map cognitive functions in the clinical condition of chronic intractable epilepsy.fMRI was used language memory network patients epilepsy pre- post-surgery.After obtaining approval from institutional ethics committee, six an equal number age-matched controls were recruited study. A 1.5 T MR scanner 12-channel head...
Temporal lobe epilepsy is associated with impairment in episodic memory. A substantial subgroup, however, able to maintain adequate memory despite temporal pathology. Missing from prior work cognitive reorganization a direct comparison of patients intact status those who are impaired. Little known about the regional activations, functional connectivities and/or network reconfigurations that implement changes primary computations or support functions drive adaptive plasticity and compensated...
An epileptogenic focus in the dominant temporal lobe can result reorganization of language systems order to compensate for compromised functions. We studied compensatory setting left epilepsy (TLE), taking into account interaction (L) with key non-language (NL) networks such as dorsal attention (DAN), fronto-parietal (FPN) and cingulo-opercular (COpN), these providing cognitive resources helpful successful performance. applied tools from dynamic network neuroscience functional MRI data...
Steinstrasse, is described as array of stone pieces in the ureter following extracorporeal shock wave lithotripsy (SWL). It well-recognized, transient event. Steinstrasse clears spontaneously, however about 6% require intervention. Spontaneous steinstrasse without prior history SWL a rare occurrence and only few case reports are published literature. Objective study was to assess aetiology management issues large spontaneous our centre.From February 2017 March 2019, 684 patients underwent...
Hemispherotomy surgery in adults is shrouded doubts regarding the functional outcome. The age at alone should not be deciding factor for surgery. Language paradigms were used magnetic resonance imaging (fMRI) to confirm role played by onset of seizures predict postoperative objective study was formulate an optimal strategy patient selection left-sided hemispherotomy adults, based on outcome analysis.A retrospective analysis 20 participants (age 1-26 years) who underwent left (over a 5-year...