A5064979397- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Hedgehog Signaling Pathway Studies
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Head and Neck Surgical Oncology
- Epilepsy research and treatment
- Muscle Physiology and Disorders
- Pituitary Gland Disorders and Treatments
- Chromatin Remodeling and Cancer
- Epigenetics and DNA Methylation
- Bone Tumor Diagnosis and Treatments
- Cancer, Hypoxia, and Metabolism
- Cerebrospinal fluid and hydrocephalus
- Microtubule and mitosis dynamics
- RNA modifications and cancer
- Brain Metastases and Treatment
- Genetic Neurodegenerative Diseases
- Fetal and Pediatric Neurological Disorders
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Tumors and Oncological Cases
All India Institute of Medical Sciences
2016-2025
Rajalakshmi Engineering College
2024
Vokkaligara Sangha Dental College & Hospital
2023
All India Institute of Medical Sciences Bhopal
2016-2022
All India Institute of Medical Sciences Raipur
2016-2022
Neurology, Inc
2004-2022
National Institute of Mental Health and Neurosciences
2014-2019
Kalasalingam Academy of Research and Education
2019
DR. B.R.A. Institute Rotary Cancer Hospital
2013-2015
Indian Institute of Science Bangalore
2011-2014
cIMPACT-NOW (the Consortium to Inform Molecular and Practical Approaches CNS Tumor Taxonomy) was established evaluate make practical recommendations on recent advances in the field of tumor classification, particularly light rapid progress molecular insights into these neoplasms. For Round 2 its deliberations, Working Committee 3 reconstituted convened Utrecht, The Netherlands, for a meeting designed review putative new types advance any future World Health Organization classification. In...
Abstract Angiotensin-converting enzyme 2 (ACE2) is a key host protein by which severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) enters and multiplies within cells. The level of ACE2 expression in the lung hypothesised to correlate with an increased risk infection complications COrona VIrus Disease 2019 (COVID-19). To test this hypothesis, we compared status immunohistochemistry (IHC) post-mortem samples patients who died COVID-19 obtained from non-COVID-19 for other indications....
Hypoxia is a critical aspect of the glioma microenvironment and has been associated with poor prognosis resistance to various therapies. However, mechanisms responsible for hypoxic survival cells remain unclear. Recent studies strongly suggest that microRNAs act as mediators response. We thus hypothesized their prominent role in hypoxia glioblastoma (GBM) aimed identify those. With this study, we present first detailed analysis small RNA transcriptome cell line U87MG, grade IV line, its...
Mutations involving isocitrate dehydrogenase 1 (IDH 1) occur in a high proportion of diffuse gliomas, with implications on diagnosis and prognosis. About 90% involve exon 4 at codon 132, replacing amino acid arginine histidine (R132H). Rarer ones include R132C, R132S, R132G, R132L, R132V, R132P. Most authors have used DNA-based methods to assess IDH1 status. Preliminary studies comparing imunohistochemistry (IHC) IDH1-R132H mutation-specific antibodies shown concordance DNA sequencing no...
Abstract Given the involvement of telomerase activation and dysregulated metabolism in glioma progression, connection between these two critical players was investigated. Pharmacological inhibition human Telomerase reverse transcriptase (hTERT) by Costunolide induced cell apoptosis a reactive oxygen species (ROS)-dependent manner. an ROS-dependent increase p53 abrogated activity. decreased Nrf2 level; ectopic expression Costunolide-induced ROS generation. While TERT knock-down levels,...
Glioblastoma multiforme (GBM) occurs rarely in children. Relatively few studies have been performed on molecular properties of pediatric GBMs. Our objective this study was to evaluate the genetic alterations GBM (age ⩽ 18 years) with special reference p53, p16, and p27 protein expression, epidermal growth factor receptor (EGFR), deletion phosphate tensin homolog gene (PTEN). Thirty cases childhood GBMs reported between January 2002 June 2007 were selected, slides stained hematoxylin eosin...
Glioblastoma (GBM) is characterized by the presence of hypoxia, stemness and local invasiveness. We have earlier demonstrated that FAT1 promotes invasiveness, inflammation upregulates HIF‐1α expression its signaling in hypoxic GBM. Here, we identified role regulating EMT (epithelial‐mesenchymal transition) characteristics The FAT1, (Snail/LOX/Vimentin/N‐cad), (SOX2/OCT4/Nestin/REST) hypoxia markers (HIF‐1α/VEGF/PGK1/CA9) was upregulated ≥39% GBM tumors ( n = 31) with significant positive...
A rapid growth in human cerebellar development occurs the third trimester, which is impeded by preterm delivery. The goal of this study was to characterize impact delivery on developmental program cerebellum. Still born infants, meant that all up age had taken place in-utero, were paired with who survived an ex-utero environment, their also outside uterus. two groups assessed quantitative measures included molecular markers granule neuron, purkinje neuron and bergmann glia differentiation,...
Background : Till date there is no published multi-institutional data regarding the epidemiological profile of pediatric brain tumors in India. Aim The present retrospective study analyses histological spectrum age group seven tertiary care hospitals Material and Methods Data frequencies various primary (diagnosed according to World Health Organization (WHO) classification), 3936 patients (<18 yrs age), was collected from India.Results most common were astrocytic (34.7%), followed by...
Abstract Background MicroRNAs (miRNAs) are non-uniformly distributed in genomes and ~30% of the miRNAs human genome clustered. In this study we have focused on imprinted miRNA cluster miR-379/miR-656 14q32.31 (hereafter C14) to test their coordinated function. We analyzed expression profile >1000 >1400 samples representing seven different tissue types obtained from cancer patients along with matched unmatched controls. Results found 68% be significantly downregulated glioblastoma...
Abstract Medulloblastoma ( MB ) is composed of four molecular subgroups viz. WNT , SHH groups 3 and 4, identified using various high‐throughput methods. Translation this data into pathologist‐friendly techniques that would be applicable in laboratories all over the world a major challenge. Ninety‐two MBs were analyzed panel 10 IHC markers, real‐time PCR for m RNA mi expression, FISH MYC amplification. β‐catenin, GAB1 YAP1 only markers utility classification three (9.8%), (45.6%) non‐ /...
The regulation of cell proliferation in the external granular layer (EGL) developing cerebellum is important for its normal patterning. An signal that regulates EGL Sonic hedgehog (Shh). Shh secreted by Purkinje cells (PC) and has a mitogenic effect on granule precursors EGL. Deregulation signaling been associated with abnormal development, implicated medulloblastomas, which are tumors arise from cerebellum. Given importance pathway development disease, there no systematic study expression...
Abstract Editing in microRNAs, particularly seed can significantly alter the choice of their target genes. We show that out 13 different human tissues, regions brain showed higher adenosine to inosine (A-to-I) editing mature miRNAs. These events were enriched sequence (73.33%), which was not observed for cytosine uracil (17.86%) editing. More than half edited miRNAs increased stability, 72.7% had ΔΔG values less −6.0 Kcal/mole and all them adenosines mis-paired with cytosines on pre-miRNA...
Abstract Elevated expression of enhancer zeste homolog 2 ( EZH 2), a histone H3K27 methyltransferase, was observed in gliomas harboring telomerase reverse transcriptase TERT ) promoter mutations. Given the known involvement and glioma progression, correlation between two subsequently its metabolic programming investigated. Inhibition human either pharmacologically or through genetic manipulation not only decreased expression, but also (i) abrogated FASN levels, (ii) de novo fatty acid...