A5023515402- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Natural Fiber Reinforced Composites
- Tribology and Wear Analysis
- ZnO doping and properties
- Curcumin's Biomedical Applications
- Ubiquitin and proteasome pathways
- Advanced machining processes and optimization
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- Sexual Differentiation and Disorders
- Conducting polymers and applications
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Circular RNAs in diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Flavonoids in Medical Research
- Histone Deacetylase Inhibitors Research
- Nanoplatforms for cancer theranostics
- Synthesis and bioactivity of alkaloids
- PI3K/AKT/mTOR signaling in cancer
- Mechanical Behavior of Composites
Sharda University
2024-2025
Indian Institute of Technology Delhi
2017-2024
All India Institute of Medical Sciences
2014-2024
Command Hospital
2024
Malaviya National Institute of Technology Jaipur
2016-2023
Post Graduate Institute of Medical Education and Research
2022-2023
Case Western Reserve University
2019-2023
University School
2019-2022
Indian Institute of Technology Bombay
2021
Central Drug Research Institute
2013-2017
Abstract Given the involvement of telomerase activation and dysregulated metabolism in glioma progression, connection between these two critical players was investigated. Pharmacological inhibition human Telomerase reverse transcriptase (hTERT) by Costunolide induced cell apoptosis a reactive oxygen species (ROS)-dependent manner. an ROS-dependent increase p53 abrogated activity. decreased Nrf2 level; ectopic expression Costunolide-induced ROS generation. While TERT knock-down levels,...
The present study reports the structural, optical and magnetic properties of ZnO with doping Er ions at dilute concentrations (0 ≤ <italic>x</italic> 0.05).
Abstract Elevated expression of enhancer zeste homolog 2 ( EZH 2), a histone H3K27 methyltransferase, was observed in gliomas harboring telomerase reverse transcriptase TERT ) promoter mutations. Given the known involvement and glioma progression, correlation between two subsequently its metabolic programming investigated. Inhibition human either pharmacologically or through genetic manipulation not only decreased expression, but also (i) abrogated FASN levels, (ii) de novo fatty acid...
Several studies on molecular profiling of oligodendrogliomas (OGs) in adults have shown a distinctive genetic pattern characterized by combined deletions chromosome arms 1p and 19q, O6-methylguanine-methyltransferase (MGMT) methylation, isocitrate dehydrogenase 1 (IDH1) mutation, which potential diagnostic, prognostic, even therapeutic relevance. OGs pediatric young adult patients are rare been poorly biological basis, it remains uncertain whether markers with prognostic significance also...
The oral route is the easiest, cost effective, and most vital method for drug administration.Therefore, improvement of dosage forms, mainly prolonged release purpose has been a challenge scientists.Vesicular delivery systems are developed with to overcome problems coupled drugs such poor bioavailability, protection from harsh gastric environment, enzymes, which degrade drug.Vesicular as liposomes, emulsions, niosomes, proniosomes, solid lipid-nano particles, ethosomes, nanoparticles,...
Recent advancement in understanding cancer etiology has highlighted epigenetic deregulation as an important phenomenon leading to poor prognosis glioblastoma (GBM). Polycomb repressive complex 2 (PRC2) is one such modifier reportedly altered GBM. However, its defined mechanism tumorigenesis still remains elusive. In present study, we analyzed our in‐house ChIPseq data for H3k27me3 modified miRNAs and identified miR‐490‐3p be the most common target GBM with significantly downregulated...
Abstract This research article presents the comparative investigation of physical, mechanical, and abrasive wear behavior chopped glass basalt fiber‐reinforced epoxy composites. The composites were fabricated by hand lay‐up technique. fiber (glass basalt) was varied in range 10 to 40 wt.% composite at an interval find out physical (density void content), mechanical (tensile strength, flexural impact strength), steady state rate, respectively. Taguchi's design experiment method used for...
The rising prevalence of cancer cells exhibits uncontrolled growth and invasive aggressive properties, leading to metastasis, which poses a significant challenge for global health. Central development are proteins such as NF-kB, p53, VEGF, BAX/Bcl-2, play important roles in angiogenesis, cell apoptosis regulation, tumor growth. This silico study evaluates the activity six different natural well novel therapeutic strategies against cancer. Using computational approach, i.e., virtual...
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Abstract TGF-β signaling provides tumor protection against colorectal cancer (CRC). Mechanisms that support its tumor-suppressive properties remain unclear. The ubiquitin ligase Arkadia/RNF111 enhances responses by targeting repressors of the pathway for degradation. corepressors SnoN/Ski, critical substrates Arkadia, complex with activated effectors Smad2/3 (pSmad2/3) on promoters target genes and block their transcription. Arkadia degrades this including pSmad2/3 unblocks promoter. Here,...
Estrogen Receptor-β (ER-β), a tumor-suppressor in prostate cancer, is epigenetically repressed by hypermethylation of its promoter. DNA-methyltransferases (DNMTs), which catalyze the transfer methyl-groups to CpG islands gene promoters, are overactive cancers and can be inhibited DNMT-inhibitors re-express tumor suppressors. The FDA-approved nucleoside like 5-Azacytidine 5-Aza-deoxycytidine carry notable concerns due their off-target toxicity, therefore non-nucleoside DNMT inhibitors...
Enhancer of zeste homolog-2(EZH2) is a key epigenetic regulator that functions as oncogene and also known for inducing altered trimethylation histone at lysine-27 (H3K27me3) mark in various tumors. However, H3K27me3 targets their precise relationship with gene expression are largely unknown astrocytic In this study, we checked EZH2 messenger RNA protein 90 tumors different grades using quantitative PCR immunohistochemistry, respectively. Further, genome-wide ChIP-seq analysis modification...
Pediatric glioblastoma multiforme (GBM) is rare, and there a single study, seminal discovery showing association of histone H3.3 isocitrate dehydrogenase (IDH)1 mutation with DNA methylation signature. The present study aims to validate these findings in an independent cohort pediatric GBM, compare it adult evaluate the involvement important functionally altered pathways. Genome-wide profiling 21 GBM cases was done compared data (GSE22867). We performed gene analysis IDH1 H3 family 3A...