A5100761935- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Gut microbiota and health
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Tuberculosis Research and Epidemiology
- Traditional Chinese Medicine Studies
- RNA Research and Splicing
- Adrenal and Paraganglionic Tumors
- Chromosomal and Genetic Variations
- Microbial metabolism and enzyme function
- Genomics and Rare Diseases
- Complement system in diseases
- Air Quality and Health Impacts
- Pituitary Gland Disorders and Treatments
- Malaria Research and Control
- Microbial Metabolic Engineering and Bioproduction
- Metabolomics and Mass Spectrometry Studies
- Air Quality Monitoring and Forecasting
- Atmospheric chemistry and aerosols
- HIV Research and Treatment
- RNA modifications and cancer
- Forensic and Genetic Research
Indian Institute of Technology Kharagpur
2023
Institute of Genomics and Integrative Biology
2014-2021
National Institute of Diabetes and Digestive and Kidney Diseases
2016-2020
National Institutes of Health
2016-2020
Academy of Scientific and Innovative Research
2014-2018
Council of Scientific and Industrial Research
2011-2014
All India Institute of Medical Sciences
2001-2011
Heterogeneity amidst healthy individuals at genomic level is being widely acknowledged. This, in turn, modulated by differential response to environmental cues and treatment regimens, necessitating the need for stratified/personalized therapy. We intend understand molecular determinants of Ayurvedic way (ancient Indian system medicine) endo-phenotyping into distinct constitution types termed "Prakriti", which forms basis personalized treatment. In this study, we explored analyzed human gut...
Survival in a given environment requires specific functions, so genomic variation is anticipated within individual taxonomic groups that exhibit large diversity lifestyles. In this study, we sequence and assemble the genome of Oceanobacillus faecalis strain HM6, resident human gut. Using genus HM6 draft sequence, explore functional requirements for survival symbiotic arrangement gut, contrast to free living environment. Comparative genomics seven available complete genomes highlight...
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Comparative genomic analysis of prokaryotes has led to a better understanding the biology several pathogenic microorganisms. One such clinically important pathogen is M. tuberculosis , leading cause bacterial infection worldwide.
Proteogenomics involves the use of MS to refine annotation protein‐coding genes and discover in a genome. We carried out comprehensive proteogenomic analysis Methylobacterium extorquens AM1 (ME‐AM1) from publicly available proteomics data with motive improve for methylotrophs; organisms capable surviving reduced carbon compounds such as methanol. Besides identifying 2482(50%) proteins, 29 new were discovered 66 annotated gene models revised ME‐AM1 One novel is identified 75 peptides, lacks...
Admixture mapping has been enormously resourceful in identifying genetic variations linked to phenotypes, adaptation, and diseases. In this study through analysis of copy number variable regions (CNVRs), we report extensive restructuring the genomes recently admixed African-Indian population (OG-W-IP) that inhabits a highly saline environment Western India. The included subjects from OG-W-IP (OG), five different Indian three HapMap populations were genotyped using Affymetrix version 6.0...
Abstract Background Obesity and energy expenditure (EE) are heritable genetic variants influencing EE may contribute to the development of obesity. We sought identify that affect in American Indians, an ethnic group with high prevalence Methods Whole-exome sequencing was performed 373 healthy Pima Indians informative for 24-hour during balance. Genetic association analyses all high-quality exonic (≥5 carriers) performed, those predicted be damaging were prioritized. Results Rs752074397...
The presence of population structure in a sample may confound the search for important genetic loci associated with disease. Our four samples Family Investigation Nephropathy and Diabetes (FIND), European Americans, Mexican African American Indians are part genome- wide association study which might be particularly important. We therefore decided to detail one component this, individual ancestry (IGA). From SNPs present on Affymetrix 6.0 Human SNP array, we identified 3 sets informative...
Air pollution adversely impacts public health. The National Capital Region (Delhi-NCR) is among the most polluted urban areas in world. One component of air PM2.5, which accounts for around 80% deaths due to pollution. Solutions lowering PM2.5 levels Delhi have been ineffective their unscientific design. In this paper, we build a mixed-methods model that captures interplay various factors—geographical, chemical, meteorological—that contribute concentration PM2.5. Using domain knowledge and...