A5059128990- Diabetes Management and Research
- Diabetes and associated disorders
- Genetic Associations and Epidemiology
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Long-Term Effects of COVID-19
- Cardiovascular Function and Risk Factors
- Chronic Lymphocytic Leukemia Research
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- COVID-19 Clinical Research Studies
- Dementia and Cognitive Impairment Research
- Bone health and osteoporosis research
- Epigenetics and DNA Methylation
- Systemic Lupus Erythematosus Research
- Blood Pressure and Hypertension Studies
- Dialysis and Renal Disease Management
- Adolescent and Pediatric Healthcare
- Cardiovascular Health and Risk Factors
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
New York University
2020-2025
Long Island University
2020-2025
NYU Langone Health
2021-2025
Wake Forest University
2014-2024
Icahn School of Medicine at Mount Sinai
2023
Diversitech (United States)
2023
Hinge Health
2023
Creative Commons
2023
Winthrop-University Hospital
2020-2021
Mayo Clinic
2021
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of study was to identify genes associated with the American population. We performed a Genome Wide Association Study (GWAS) Affymetrix 6.0 array 965 African-American cases and end-stage renal disease (T2DM-ESRD) 1029 population-based controls. most significant SNPs (n = 550 independent loci) were genotyped...
IMPORTANCE Despite concern about an "epidemic," there are limited data on trends in prevalence of either type 1 or 2 diabetes across US race and ethnic groups.OBJECTIVE To estimate changes the youth, by sex, age, race/ethnicity between 2001 2009.DESIGN, SETTING, AND PARTICIPANTS Case patients were ascertained 4 geographic areas managed health care plan.The study population was determined 2009 bridged-race intercensal estimates for sites membership counts plan.MAIN OUTCOMES MEASURES...
Diagnoses of type 1 and 2 diabetes in youths present a substantial clinical public health burden. The prevalence these diseases increased the 2001-2009 period, but data on recent incidence trends are lacking.
<h3>Importance</h3> Changes in the prevalence of youth-onset diabetes have previously been observed. <h3>Objective</h3> To estimate changes type 1 and 2 youths US from 2001 to 2017. <h3>Design, Setting, Participants</h3> In this cross-sectional observational study, individuals younger than 20 years with physician-diagnosed were enumerated 6 areas (4 geographic areas, health plan, select American Indian reservations) for 2001, 2009, <h3>Exposures</h3> Calendar year. <h3>Main Outcomes...
To estimate the prevalence of diabetes in U.S. youth aged <20 years 2009 and to total number with by age, race/ethnicity, type.
Diabetes is one of the most common chronic diseases among persons aged <20 years (1). Onset diabetes in childhood and adolescence associated with numerous complications, including diabetic kidney disease, retinopathy, peripheral neuropathy, has a substantial impact on public health resources (2,3). From 2002 to 2012, type 1 2 incidence increased 1.4% 7.1%, respectively, U.S. youths (4). To assess recent trends (defined for this report as years), researchers analyzed 2002-2015 data from...
Coding variants in the apolipoprotein L1 gene (APOL1) are strongly associated with nephropathy African Americans (AAs). The effect of transplanting kidneys from AA donors two APOL1 risk is unknown. were genotyped 106 deceased organ and graft survival assessed 136 resultant kidney transplants. Cox-proportional hazard models tested for association between time to failure donor genotypes. mean follow-up was 26.4 ± 21.8 months. Twenty-two transplanted (16%) variants. Twenty-five grafts failed;...
We assessed the prevalence of and risk factors for diabetic peripheral neuropathy (DPN) in youth with type 1 diabetes (T1D) 2 (T2D) enrolled SEARCH Diabetes Youth (SEARCH) study.
Stratification of patients with post-acute sequelae SARS-CoV-2 infection (PASC, or long COVID) would allow precision clinical management strategies. However, COVID is incompletely understood and characterised by a wide range manifestations that are difficult to analyse computationally. Additionally, the generalisability machine learning classification COVID-19 outcomes has rarely been tested.
Abstract Long COVID, or complications arising from COVID-19 weeks after infection, has become a central concern for public health experts. The United States National Institutes of Health founded the RECOVER initiative to better understand long COVID. We used electronic records available through COVID Cohort Collaborative characterize association between SARS-CoV-2 vaccination and diagnosis. Among patients with infection August 1, 2021 January 31, 2022, we defined two cohorts using distinct...
OBJECTIVE To project the prevalence and number of youths with diabetes trends in racial ethnic disparities U.S. through 2060. RESEARCH DESIGN AND METHODS Based on a mathematical model data from SEARCH for Diabetes Youth study calendar years 2002–2017, we projected future type 1 2 among youth aged &lt;20 while considering different scenarios incidence. RESULTS The will increase 213,000 (95% CI 209,000; 218,000) (type 185,000, 28,000) 2017 to 239,000 282,000) 191,000, 48,000) 2060 if...
In Brief Background Two apolipoprotein L1 gene (APOL1) renal-risk variants in donors and African American (AA) recipient race are associated with worse allograft survival deceased-donor kidney transplantation (DDKT) from AA donors. To detect other factors impacting deceased donors, APOL1 were genotyped additional Methods The genotypes linked to outcomes 478 newly analyzed DDKTs the Scientific Registry of Transplant Recipients. Multivariate analyses accounting for age, sex, race,...
Several whole-genome association studies have reported identification of type 2 diabetes susceptibility genes in various European-derived study populations. Little investigation these loci has been other ethnic groups, specifically African Americans. Striking differences exist between populations, suggesting they may not share identical genetic risk factors. Our objective was to examine the influence identified a large American case-control population.Single nucleotide polymorphisms (SNPs)...
OBJECTIVE To estimate the prevalence of and risk factors for diabetic peripheral neuropathy (DPN) in a pilot study among youth participating SEARCH Diabetes Youth study. RESEARCH DESIGN AND METHODS DPN was assessed using Michigan Neuropathy Screening Instrument (MNSI) (examination foot abnormalities, distal vibration perception, ankle reflexes). An MNSI exam (MNSIE) score &gt;2 is diagnostic DPN. RESULTS The MNSIE completed 399 subjects, including 329 with type 1 diabetes (mean age 15.7...
Genetic risk scores (GRS) have been developed that differentiate individuals with type 1 diabetes from those other forms of and are starting to be used for population screening; however, most studies were conducted in European-ancestry populations. This study identifies novel genetic variants associated African-ancestry participants develops an African-specific GRS.
Much of the higher risk for end-stage kidney disease (ESKD) in African American individuals relates to ancestry-specific variation apolipoprotein L1 gene (