A5109052253- Blood Pressure and Hypertension Studies
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Statistical Methods in Clinical Trials
- Health Systems, Economic Evaluations, Quality of Life
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
- Meta-analysis and systematic reviews
- Folate and B Vitamins Research
- Dementia and Cognitive Impairment Research
- Nutritional Studies and Diet
- Heart Rate Variability and Autonomic Control
- Menopause: Health Impacts and Treatments
- Estrogen and related hormone effects
- Pharmacology and Obesity Treatment
- Obstructive Sleep Apnea Research
- Trace Elements in Health
- Hemodynamic Monitoring and Therapy
- Obesity and Health Practices
- Psoriasis: Treatment and Pathogenesis
- Healthcare Policy and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Suicide and Self-Harm Studies
- Neuroscience of respiration and sleep
- Cerebrovascular and Carotid Artery Diseases
Wake Forest University
2016-2025
University of Alabama at Birmingham
2002-2022
National Institute on Aging
2022
National Institute of Diabetes and Digestive and Kidney Diseases
2022
Johns Hopkins University
2022
Sprint (United States)
2020-2021
Case Western Reserve University
2015-2021
National Heart Lung and Blood Institute
2015-2021
National Institutes of Health
2021
University of Tennessee Health Science Center
2015-2021
Weight loss is recommended for overweight or obese patients with type 2 diabetes on the basis of short-term studies, but long-term effects cardiovascular disease remain unknown. We examined whether an intensive lifestyle intervention weight would decrease morbidity and mortality among such patients.In 16 study centers in United States, we randomly assigned 5145 to participate that promoted through decreased caloric intake increased physical activity (intervention group) receive support...
Heart disease is a major cause of illness and death in women. To understand better the role estrogen treatment prevention heart disease, more information needed about its effects on coronary atherosclerosis extent to which concomitant progestin therapy may modify these effects.
<h3>Background</h3> Lifestyle interventions produce short-term improvements in glycemia and cardiovascular disease (CVD) risk factors individuals with type 2 diabetes mellitus, but no long-term data are available. We examined the effects of lifestyle intervention on changes weight, fitness, CVD during a 4-year study. <h3>Methods</h3> The Look AHEAD (Action for Health Diabetes) trial is multicenter randomized clinical comparing an intensive (ILI) support education (DSE; control group)...
There are currently no proven treatments to reduce the risk of mild cognitive impairment and dementia.To evaluate effect intensive blood pressure control on dementia.Randomized clinical trial conducted at 102 sites in United States Puerto Rico among adults aged 50 years or older with hypertension but without diabetes history stroke. Randomization began November 8, 2010. The was stopped early for benefit its primary outcome (a composite cardiovascular events) all-cause mortality August 20,...
Iron overload and hemochromatosis are common, treatable conditions. HFE genotypes, levels of serum ferritin, transferrin saturation values, self-reported medical history were studied in a multiethnic primary care population.Participants recruited from practices blood-drawing laboratories. Blood samples tested for saturation, C282Y H63D mutations the gene. Before genetic screening, participants asked whether they had conditions related to iron overload.Of 99,711 participants, 299 homozygous...
Background: High blood pressure is an important public health concern because it highly prevalent and a risk factor for adverse outcomes, including coronary heart disease, stroke, decompensated failure, chronic kidney decline in cognitive function. Observational studies show progressive increase associated with above 115/75 mm Hg. Prior research has shown that reducing elevated systolic lowers the of subsequent clinical complications from cardiovascular disease. However, optimal to reduce...
The effect of intensive blood pressure lowering on brain health remains uncertain.To evaluate the association treatment with cerebral white matter lesion and volumes.A substudy a multicenter randomized clinical trial hypertensive adults 50 years or older without history diabetes stroke at 27 sites in United States. Randomization began November 8, 2010. overall was stopped early because benefit for its primary outcome (a composite cardiovascular events) all-cause mortality August 20, 2015....
The appropriate target for BP in patients with CKD and hypertension remains uncertain. We report prespecified subgroup analyses of outcomes participants baseline the Systolic Blood Pressure Intervention Trial. randomly assigned to a systolic <120 mm Hg (intensive group; n =1330) or <140 (standard =1316). After median follow-up 3.3 years, primary composite cardiovascular outcome occurred 112 intensive group 131 standard (hazard ratio [HR], 0.81; 95% confidence interval [95% CI], 0.63...
In a previously reported randomized trial of standard and intensive systolic blood-pressure control, data on some outcome events had yet to be adjudicated post-trial follow-up not been collected.
To examine whether the initial benefit of weight loss on obstructive sleep apnea (OSA) severity at 1 year is maintained 4 years. Randomized controlled trial with follow-up 1, 2, and Look AHEAD clinical centers. Two hundred sixty-four obese adults type 2 diabetes OSA. Intensive lifestyle intervention a behavioral program or support education. Change in apnea-hypopnea index polysomnogram. The intensive group's mean was 10.7 ± 0.7 (standard error), 7.4 0.7, 5.2 kg years respectively, compared...
Recent publications have stated that the blood pressure (BP) measurement technique used in SPRINT (Systolic Blood Pressure Intervention Trial) was unattended. However, protocol does not address issue of attendance. A survey conducted immediately after closeout visits were completed to inquire whether BP measurements usually attended or unattended by staff. There 4082 participants at 38 sites measured leaving participant alone entire time (always alone), 2247 25 had personnel room (never 1746...
Sequence variants in the gene encoding estrogen receptor α (ER-α) may modify effects of hormone-replacement therapy on levels high-density lipoprotein (HDL) cholesterol and other outcomes related to treatment postmenopausal women.
Background — The estrogen receptor-α (ER-α) IVS1-401 polymorphism identifies a group of women (≈20%) who have augmented effects hormone replacement therapy (HRT) on levels HDL cholesterol. This study sought to determine if this augmentation extends HRT regulation E-selectin and C-reactive protein (CRP) explore possible mechanisms by which might influence action. Methods Results Serum soluble CRP were measured at baseline 1 year in 264 postmenopausal randomized treatment with oral conjugated...
<h3>Background</h3> The antidepressant and cognitive side effects of right unilateral (RUL) electroconvulsive therapy (ECT) are reported to depend on the magnitude electrical stimulus relative seizure threshold. doses explored in previous clinical trials RUL ECT have generally been limited 1 2.5 times convulsive threshold efficacy has low compared with bilateral (BL) ECT. present study compares 2 dosing strategies: titrated moderately suprathreshold fixed high dose. <h3>Methods</h3>...
Rationale: Weight loss is recommended to treat obstructive sleep apnea (OSA).Objectives: To determine whether the initial benefit of intensive lifestyle intervention (ILI) for weight on OSA severity maintained at 10 years.Methods: Ten-year follow-up polysomnograms 134 264 adults in Sleep AHEAD (Action Health Diabetes) with overweight/obesity, type 2 diabetes mellitus, and were randomized ILI or support education (DSE).Measurements Main Results: Change apnea-hypopnea index (AHI) was measured....