A5066813537- Indigenous Health, Education, and Rights
- Indigenous Studies and Ecology
- Dementia and Cognitive Impairment Research
- Geriatric Care and Nursing Homes
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Nursing Roles and Practices
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Athletic Training and Education
- Health disparities and outcomes
- Health Policy Implementation Science
- Diabetes Management and Education
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Primary Care and Health Outcomes
- Chronic Disease Management Strategies
- Data Quality and Management
- Aortic Disease and Treatment Approaches
- Community Health and Development
- Simulation-Based Education in Healthcare
- Cardiac, Anesthesia and Surgical Outcomes
- Surgical Simulation and Training
- Cardiac pacing and defibrillation studies
Laurentian University
2016-2024
Flinders Medical Centre
2024
University of Toronto
2019-2024
McMaster University
2021-2024
Impact
2022-2024
University of Massachusetts Chan Medical School
2016-2024
Sinai Hospital
2024
Canadian Apheresis Group
2024
Public Health Ontario
2020-2024
University of North Carolina at Chapel Hill
2024
Concerns about secondary use of data and limited opportunities for benefit-sharing have focused attention on the tension that Indigenous communities feel between (1) protecting rights interests in (including traditional knowledges) (2) supporting open data, machine learning, broad sharing, big initiatives. The International Data Sovereignty Interest Group (within Research Alliance) is a network nation-state based sovereignty networks individuals developed 'CARE Principles Governance'...
The effect of intensive blood pressure lowering on brain health remains uncertain.To evaluate the association treatment with cerebral white matter lesion and volumes.A substudy a multicenter randomized clinical trial hypertensive adults 50 years or older without history diabetes stroke at 27 sites in United States. Randomization began November 8, 2010. overall was stopped early because benefit for its primary outcome (a composite cardiovascular events) all-cause mortality August 20, 2015....
The fifth-generation SAPIEN 3 Ultra Resilia valve (S3UR) incorporates several design changes as compared with its predecessors, the (S3) and (S3U) valves, including bovine leaflets treated a novel process intended to reduce structural deterioration via calcification, well taller external skirt on 29-mm size paravalvular leak (PVL). clinical performance of S3UR S3 S3U in large patient population has not been previously reported.
Abstract —The development of congestive heart failure (CHF) is associated with left ventricular (LV) dilation and myocardial remodeling. However, fundamental mechanisms that contribute to this remodeling process the progression CHF remain unclear. The matrix metalloproteinases (MMPs) have been demonstrated play a significant role in tissue number pathological processes. present project tested hypothesis LV during early changes MMP expression zymographic activity. myocyte function, collagen...
Indigenous Peoples' right to sovereignty forms the foundation for advocacy and actions toward greater self-determination control across a range of domains that impact communities cultures. Declarations are rising throughout diverse fields, including Network Sovereignty, Food Energy Data Sovereignty. Research Sovereignty draws in discourse these initiatives consider their applications broader research ecosystem. Our exploration or context activities, has been focused on relationship between...
Meta-analyses of randomized clinical trials have indicated that improved hypertension control reduces the risk for cognitive impairment and dementia. However, it is unclear to what extent pathways reflective Alzheimer disease (AD) pathology are affected by control.To evaluate association intensive blood pressure on AD-related brain biomarkers.This a substudy Systolic Blood Pressure Intervention Trial (SPRINT MIND), multicenter trial compared efficacy 2 different pressure-lowering strategies....
Introduction The aim of our study was to assess the initial impact COVID-19 on total publicly-funded direct healthcare costs and health services use in two Canadian provinces, Ontario British Columbia (BC). Methods This retrospective repeated cross-sectional used population-based administrative datasets, linked within each province, from January 1, 2018 December 27, 2020. Interrupted time series analysis estimate changes level trends weekly resource costs, with March 16–22, 2020 as first...
Background Plasma levels of endothelin-1 (ET-1) are increased in patients and animals with severe congestive heart failure (CHF). It remains unknown, however, whether ET-1 plays a direct contributory role the progression CHF. Accordingly, present project tested hypothesis that chronic blockade ET A receptor would have beneficial effects on left ventricular (LV) myocyte function model Methods Results Global LV isolated were examined rabbits following groups (12 per group): rapid pacing (RVP;...
Background Clinical trials have demonstrated that angiotensin-converting enzyme inhibition (ACEI) improves survival in patients with long-term left ventricular (LV) dysfunction. However, it remained unclear from these clinical reports whether the beneficial effects of ACEI were due to direct improvements LV myocardial structure and function. Accordingly, overall objective present study was examine on both myocyte function setting cardiomyopathic disease. Methods Results isolated examined...
The provision of preventive services and continuity care are important aspects long-term (LTC). A proposed quality indicator such is the rate hospitalizations due to ambulatory sensitive conditions (ACSCs). As ACSC approach identifying potentially avoidable (PAH) was developed for younger community-dwelling adults in United States, we sought examine its applicability as a older institutionalized residents Canada.ACSCs were identified linked hospital-based LTC acute administrative database at...
Objectives: To determine whether baseline self‐rated health (SRH) independently predicted survival in an older Canadian population and to investigate the role of cognition on SRH‐mortality relationship. Design: Population‐based prospective cohort study. Setting: Ten provinces, community‐based. Participants: A total 8,697 community‐dwelling participants aged 65 older. Measurements: Self‐reported measures overall health, physical function, comorbidities, demographic characteristics were...