A5050932952- Health Systems, Economic Evaluations, Quality of Life
- Respiratory Support and Mechanisms
- Cancer survivorship and care
- Gestational Diabetes Research and Management
- Meta-analysis and systematic reviews
- Childhood Cancer Survivors' Quality of Life
- Hemoglobinopathies and Related Disorders
- Rheumatoid Arthritis Research and Therapies
- Prostate Cancer Diagnosis and Treatment
- Statistical Methods in Clinical Trials
- Obstructive Sleep Apnea Research
- Prostate Cancer Treatment and Research
- Intensive Care Unit Cognitive Disorders
- Diabetes Management and Research
- Iron Metabolism and Disorders
- Neutropenia and Cancer Infections
- Pregnancy and preeclampsia studies
- Bone health and osteoporosis research
- Transplantation: Methods and Outcomes
- Autoimmune and Inflammatory Disorders Research
- Hepatitis C virus research
- Cancer Treatment and Pharmacology
- Healthcare Policy and Management
- Cardiac Arrest and Resuscitation
- Liver Disease Diagnosis and Treatment
University of Toronto
2016-2025
University Health Network
2016-2025
Public Health Ontario
2015-2025
Sinai Health System
2014-2025
Mount Sinai Hospital
2011-2024
Toronto General Hospital
2015-2024
Toronto General Hospital Research Institute
2005-2024
Sinai Hospital
2011-2024
3M (United States)
2011-2024
Toronto Public Health
2011-2024
There have been few detailed, in-person interviews and examinations to obtain follow-up data on 5-year outcomes among survivors of the acute respiratory distress syndrome (ARDS).
The Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure trial tested the hypothesis that continuous positive airway pressure (CPAP) would improve survival rate without heart transplantation of patients who have central sleep apnea failure.
In the main analysis of Canadian Continuous Positive Airway Pressure (CPAP) for Patients with Central Sleep Apnea (CSA) and Heart Failure Trial (CANPAP), CPAP had no effect on heart transplant-free survival; however, only reduced mean apnea-hypopnea index to 19 events per hour sleep, which remained above trial inclusion threshold 15. This stratified CANPAP tested hypothesis that suppression CSA below this by would improve left ventricular ejection fraction survival.Of 258 failure patients in...
Morbidity and mortality in spontaneous intracerebral hemorrhage (ICH) are correlated with hematoma progression. We hypothesized that the presence of tiny, enhancing foci ("spot sign") within acute hematomas is associated expansion.We prospectively studied 39 consecutive patients ICH by computed tomography angiography 3 hours symptom onset. Scans were reviewed readers. Patients dichotomized according to or absence spot sign. Clinical radiological outcomes compared between groups. The...
Pregnant women with type 1 diabetes are a high-risk population who recommended to strive for optimal glucose control, but neonatal outcomes attributed maternal hyperglycaemia remain suboptimal. Our aim was examine the effectiveness of continuous monitoring (CGM) on control and obstetric health outcomes.In this multicentre, open-label, randomised controlled trial, we recruited aged 18-40 years minimum 12 months were receiving intensive insulin therapy. Participants pregnant (≤13 weeks 6 days'...
Diaphragm dysfunction worsens outcomes in mechanically ventilated patients, but the clinical impact of potentially preventable changes diaphragm structure and function caused by mechanical ventilation is unknown.To determine whether atrophy developing during leads to prolonged ventilation.Diaphragm thickness was measured daily ultrasound adults requiring invasive ventilation; inspiratory effort assessed thickening fraction. The primary outcome time liberation from ventilation. Secondary...
Rationale: Diaphragm atrophy and dysfunction have been reported in humans during mechanical ventilation, but the prevalence, causes, functional impact of changes diaphragm thickness routine ventilation for critically ill patients are unknown.Objectives: To describe evolution over time its on function, influence inspiratory effort this phenomenon.Methods: In three academic intensive care units, 107 were enrolled shortly after initiating along with 10 nonventilated unit (control subjects)....
Rationale: Little is known about the long-term outcomes and costs of survivors acute respiratory distress syndrome (ARDS).Objectives: To describe functional quality life outcomes, health care use, ARDS 2 yr after intensive unit (ICU) discharge.Methods: We recruited a cohort from four academic tertiary ICUs in Toronto, Canada, prospectively monitored them ICU admission to discharge.Measurements: Clinical direct medical costs.Results: Eighty-five percent patients with discharged survived yr;...
Bayesian analysis of clinical trial data may provide useful information to aid in study interpretation, especially when evidence suggests that the benefits an intervention are uncertain, such as a evaluated early extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS).To demonstrate potential utility analyses by estimating posterior probability, under various assumptions, ECMO was associated with reduced mortality patients very ARDS randomized (RCT).A...
Tetyana Kendzerska and colleagues explore the association between physiological measures of obstructive sleep apnea other than apnea-hypopnea index risk cardiovascular events. Please see later in article for Editors' Summary
The aim of this study was to determine if body mass index (BMI) an independent predictor response antiviral treatment in patients with chronic hepatitis C. A retrospective review performed all at a single center C treated medication from 1989 2000. sustained defined as either negative virus (HCV) RNA by polymerase chain reaction and/or normal alanine aminotransferase (ALT) level (only those before availability HCV testing) 6 months following completion therapy. All were classified into one 3...
Few resources are available to support caregivers of patients who have survived critical illness; consequently, the caregivers' own health may suffer. We studied caregiver and patient characteristics determine which were associated with outcomes during first year after discharge from an intensive care unit (ICU).We prospectively enrolled 280 had received 7 or more days mechanical ventilation in ICU. Using hospital data self-administered questionnaires, we collected information on...
Disability risk groups and 1-year outcome after greater than or equal to 7 days of mechanical ventilation (MV) in medical/surgical intensive care unit (ICU) patients are unknown may inform education, prognostication, rehabilitation, study design.To stratify for post-ICU disability recovery 1 year critical illness.We evaluated a multicenter cohort 391 ICU who received week MV at 3, 6, 12 months discharge. were identified using recursive partitioning modeling.The 7-day Functional Independence...