A5033864764- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Polyomavirus and related diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Mechanical Circulatory Support Devices
- Antifungal resistance and susceptibility
- Tracheal and airway disorders
- Pulmonary Hypertension Research and Treatments
- Cytomegalovirus and herpesvirus research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mycobacterium research and diagnosis
- Organ and Tissue Transplantation Research
- Cystic Fibrosis Research Advances
- Nutrition and Health in Aging
- Fungal Infections and Studies
- Medical Imaging and Pathology Studies
- Palliative Care and End-of-Life Issues
- Hepatitis C virus research
- Dysphagia Assessment and Management
- Tuberous Sclerosis Complex Research
- Pneumonia and Respiratory Infections
- Frailty in Older Adults
University of Toronto
2016-2025
University Health Network
2016-2025
Toronto General Hospital
2016-2025
Toronto General Hospital Research Institute
2022-2025
Johns Hopkins University
2024
Duke University
2024
Mathura Das Mathur Hospital
2022
Singer (United States)
2014-2022
University of California, San Francisco
2021
Health Net
2014-2021
Lymphangioleiomyomatosis (LAM) is a progressive, cystic lung disease in women; it associated with inappropriate activation of mammalian target rapamycin (mTOR) signaling, which regulates cellular growth and lymphangiogenesis. Sirolimus (also called rapamycin) inhibits mTOR has shown promise phase 1-2 trials involving patients LAM.We conducted two-stage trial sirolimus 89 LAM who had moderate impairment--a 12-month randomized, double-blind comparison placebo, followed by observation period....
More than 80% of donor lungs are potentially injured and therefore not considered suitable for transplantation. With the use normothermic ex vivo lung perfusion (EVLP), retrieved can be perfused in an circuit, providing opportunity to reassess its function before In this study, we examined feasibility transplanting high-risk that have undergone EVLP.In prospective, nonrandomized clinical trial, subjected high risk transplantation 4 hours EVLP. High-risk were defined by specific criteria,...
Few resources are available to support caregivers of patients who have survived critical illness; consequently, the caregivers' own health may suffer. We studied caregiver and patient characteristics determine which were associated with outcomes during first year after discharge from an intensive care unit (ICU).We prospectively enrolled 280 had received 7 or more days mechanical ventilation in ICU. Using hospital data self-administered questionnaires, we collected information on...
Disability risk groups and 1-year outcome after greater than or equal to 7 days of mechanical ventilation (MV) in medical/surgical intensive care unit (ICU) patients are unknown may inform education, prognostication, rehabilitation, study design.To stratify for post-ICU disability recovery 1 year critical illness.We evaluated a multicenter cohort 391 ICU who received week MV at 3, 6, 12 months discharge. were identified using recursive partitioning modeling.The 7-day Functional Independence...
A consensus conference on frailty in kidney, liver, heart, and lung transplantation sponsored by the American Society of Transplantation (AST) endorsed Nephrology (ASN), Transplant Surgeons (ASTS), Canadian (CST) took place February 11, 2018 Phoenix, Arizona. Input from transplant community through scheduled calls enabled wide discussion current concepts frailty, exploration best practices for risk assessment candidates management after transplant, development ideas future research....
In the absence of standardized diagnosis and presence unique clinical syndromes, it is not surprising that considerable differences exist in number reported incidences disease outcomes various infections cardiothoracic transplant (CTTX) recipients. Publications to date have employed variable heterogeneous definitions CTTX-related infections, thereby limiting comparison between types incidence generalizability these data across centers. Currently, there are no standard international for...
BackgroundVEGF-D is a lymphangiogenic growth factor that has key role in tumour metastasis. Serum VEGF-D concentrations are increased most patients with lymphangioleiomyomatosis, rare neoplasm associated mTOR-activating tuberous sclerosis gene mutations, lymphadenopathy, metastatic spread, and pulmonary cyst formation. We used data from the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial to assess usefulness serum concentration as marker severity...
Gastro-esophageal reflux and related pulmonary bile acid aspiration were prospectively investigated as possible contributors to postlung transplant bronchiolitis obliterans syndrome (BOS). We also studied the impact of on surfactant collectin proteins SP-A SP-D phospholipids--all important components innate immunity in lung. Proximal distal esophageal 24-h pH testing broncho-alveolar lavage fluid (BALF) assays performed at 3-month posttransplant 50 patients. BALF was assayed for SP-A,...
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The optimal timing for listing of cystic fibrosis patients lung transplantation is controversial.We conducted a retrospective cohort study 343 listed at four academic medical centers to identify risk factors death while awaiting transplantation.Data on possible were abstracted from records.Time death, patient demographic characteristics, and assessed. Univariate multivariate survival analyses performed using Cox regression.By univariate analyses, FEV1 < or = 30% predicted (HR, 3.8; 95% CI,...
Previously established predictors of survival may no longer apply in the current era cystic fibrosis (CF) care. Our objective was to identify risk factors associated with a contemporary CF population. We used Canadian Registry, population-based cohort, calculate median age and summarise patient characteristics from 1990 2012. Clinical, demographic geographical factors, were estimated for cohort (2000–2012) using Cox proportional hazards models. There 5787 individuals registry between Median...
Rationale: Despite increasing evidence about the role of donor-specific human leukocyte antigen (HLA) antibodies in transplant outcomes, incidence and impact de novo (dnDSA) after lung transplantation remains unclear.Objectives: To describe incidence, characteristics, dnDSA transplantation.Methods: We investigated a single-center cohort 340 recipients undergoing during 2008 to 2011. All patients underwent HLA-antibody testing quarterly pretransplant at regular intervals over first 24 months...
The annual standard-dose (SD) influenza vaccine has suboptimal immunogenicity in solid organ transplant recipients (SOTRs). Influenza that contains higher doses of antigens may lead to greater this population.We conducted a randomized, double-blind trial compare the safety and 2016-2017 high-dose (HD; FluzoneHD, Sanofi) vs SD (Fluviral, GSK) adult SOTRs. Preimmunization 4-week postimmunization sera underwent strain-specific hemagglutination inhibition assay.We enrolled 172 patients who...