A5007226058- Organ Transplantation Techniques and Outcomes
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Organ Donation and Transplantation
- Nutrition and Health in Aging
- Frailty in Older Adults
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Pancreatitis Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Transplantation: Methods and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Epigenetics and DNA Methylation
- Hepatitis C virus research
- Colorectal Cancer Surgical Treatments
- Clinical Nutrition and Gastroenterology
- Neurological Complications and Syndromes
- Pediatric Hepatobiliary Diseases and Treatments
- Colorectal Cancer Screening and Detection
- Hip and Femur Fractures
University of Michigan
2015-2024
Michigan Medicine
2011-2024
Erasmus MC Transplant Institute
2023
University Medical Center Groningen
2023
University of Groningen
2023
Erasmus MC Cancer Institute
2023
University of California, Los Angeles
2021
University of Toledo
2021
Michigan United
2019
Analysis Group (United States)
2013-2015
Although sarcopenia (muscle loss) is associated with increased mortality after liver transplantation, its influence on other complications less well understood. We examined the association between and risk of severe posttransplant infections among adult transplant recipients. By calculating total psoas area (TPA) preoperative computed tomography scans, we assessed 207 The presence or absence a infection was determined by review medical chart. overall survival also assessed. identified 196...
The ability to predict outcomes following a kidney transplant is limited by the complex physiologic decline of failure, latent factor that difficult capture using conventional comorbidity assessment. frailty phenotype recently described inflammatory state increased vulnerability stressors resulting from decreased reserve and dysregulation multiple systems. We hypothesized would be associated with delayed graft function, based on putative associations between cytokines dysfunction....
Frailty has emerged as a powerful predictor of outcomes in patients with cirrhosis and inevitably made its way into decision making within liver transplantation. In an effort to harmonize integration the concept frailty among transplant centers, AST ASTS supported efforts our working group develop this statement from experts field. is multidimensional construct that represents end-manifestation derangements multiple physiologic systems leading decreased reserve increased vulnerability health...
Loss of muscle mass and function, or sarcopenia, is a common feature cirrhosis contributes significantly to morbidity mortality in this population. Sarcopenia main indicator adverse outcomes population, including poor quality life, hepatic decompensation, patients with evaluated for liver transplantation (LT), longer hospital intensive care unit stay, higher incidence infection following LT, overall health cost. Although it clear that an important predictor LT outcomes, many questions...
A consensus conference on frailty in kidney, liver, heart, and lung transplantation sponsored by the American Society of Transplantation (AST) endorsed Nephrology (ASN), Transplant Surgeons (ASTS), Canadian (CST) took place February 11, 2018 Phoenix, Arizona. Input from transplant community through scheduled calls enabled wide discussion current concepts frailty, exploration best practices for risk assessment candidates management after transplant, development ideas future research....
Abstract The adult healthy human pancreas has been poorly studied given the lack of indication to obtain tissue from in absence disease and rapid postmortem degradation. We obtained pancreata brain dead donors, thus avoiding any warm ischemia time. 30 donors were diverse age race had no known disease. Histopathologic analysis samples revealed pancreatic intraepithelial neoplasia (PanIN) lesions most individuals irrespective age. Using a combination multiplex IHC, single-cell RNA sequencing,...
To compare conventional low-temperature storage of transplant donor livers [static cold (SCS)] with the organs at physiological body temperature [normothermic machine perfusion (NMP)].
The effects of occlusive portal vein thrombosis (PVT) on the survival patients with cirrhosis are unknown. This was a retrospective cohort study at single center. main exposure variable presence PVT. primary outcome measure time-dependent mortality. A total 3295 were analyzed, and 148 (4.5%) had Variables independently predictive mortality from time liver transplant evaluation included age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.01-1.03], Model for End-Stage Liver Disease...
Assess the relationship between lean core muscle size, measured on preoperative cross-sectional images, and surgical outcomes.Novel measures of risk are needed. Analytic morphomic analysis diagnostic images may elucidate vast amounts patient-specific data, which never assessed by clinicians.The study population included all patients within Michigan Surgical Quality Collaborative database with a computerized tomography(CT) scan before major, elective general or vascular surgery (N = 1453)....
Recently, the American Joint Committee on Cancer (AJCC) released its 8th edition changes to staging system for hepatocellular cancer (HCC). We sought validate and compare performance 7th using a population-based data set.Using Surveillance, Epidemiology End Results (SEER) database (1998-2013), patients undergoing resection or transplant non-metastatic HCC were identified. Overall survival was estimated Kaplan-Meier method compared log-rank tests. Concordance indices (c-indices) calculated...
Background. Solid organ transplant (SOT) recipients are considered to be “vulnerable” COVID-19 infection due immunosuppression. To date, there no studies that compared the disease severity of in SOT with nontransplant patients. Methods. In this case-control study, we outcomes between and their matched controls. The cases were all adult (N = 41) from our academic health center who diagnosed March 10, 2020 May 15, using positive reverse transcriptase polymerase chain reaction for SARS-CoV2....
PURPOSE: Appropriate use of adjuvant chemotherapy is a widely recognized quality measure colorectal cancer care. The objective this study was to test the hypothesis that surgical complications are associated with omission for cancer. METHODS: We used 1998 2005 Surveillance, Epidemiology and End Results-Medicare database among patients stage III who underwent resection. Chemotherapy compared between without complications. Univariate analyses multiple logistic regression were association...
Better measures of liver transplant risk stratification are needed. Our previous work noted a strong relationship between psoas muscle area and survival following transplantation. The dorsal group is easier to measure, but it unclear if they also correlated with surgical outcomes.Our study population included recipients preoperative CT scan. Cross-sectional areas the at T12 vertebral level were measured. primary outcomes for this one- five-yr mortality one-yr complications....
In an effort to understand the diminished quality of life (QoL) exhibited by patients with end-stage liver disease (ESLD), we studied association frailty and severity in this patient population.In a prospective, single-center cohort study (N=487), assessed QoL ESLD referred for transplant. Frailty was measured on scale from 0 5 grip strength, gait speed, exhaustion, shrinkage, physical activity, scores 3 or higher characterized as frail. Physical, mental, combined overall ranging 100 were...
End-stage liver disease (ESLD) patients are believed to have a high prevalence of depression, although mental health in ESLD has not been studied comprehensively. Further, the relationship between depression and severity is unclear. Using baseline data from large prospective cohort study (N = 500) frailty patients, we association with depression. Frailty was assessed five-component Fried Index. Patients were assigned composite score 0 5, scores ≥3 considered frail. Depression using...