A5041311658- Automotive and Human Injury Biomechanics
- Nutrition and Health in Aging
- Immune Response and Inflammation
- Trauma and Emergency Care Studies
- Injury Epidemiology and Prevention
- Frailty in Older Adults
- Cardiac, Anesthesia and Surgical Outcomes
- Burn Injury Management and Outcomes
- Traffic and Road Safety
- Wound Healing and Treatments
- Pelvic and Acetabular Injuries
- Cardiac Arrest and Resuscitation
- Autopsy Techniques and Outcomes
- Hip and Femur Fractures
- Heterotopic Ossification and Related Conditions
- Liver Disease Diagnosis and Treatment
- Microfluidic and Capillary Electrophoresis Applications
- Body Composition Measurement Techniques
- Colorectal Cancer Surgical Treatments
- Organ Transplantation Techniques and Outcomes
- Trauma Management and Diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease and Transplantation
- Microfluidic and Bio-sensing Technologies
- Bone fractures and treatments
University of Michigan–Ann Arbor
2016-2025
Morpho (United States)
2015-2024
Analysis Group (United States)
2015-2024
Michigan Medicine
2014-2024
Ann Arbor Center for Independent Living
1994-2024
Viavi Solutions (United Kingdom)
2024
A. Alfred Taubman Health Care Center
2015-2024
Wayne State University
2024
Memorial Hospital of South Bend
2020
First Affiliated Hospital of Henan University of Science and Technology
2020
Nitric oxide is a short-lived biologic mediator for diverse cell types. Synthesis of an inducible nitric synthase (NOS) in murine macrophages stimulated by lipopolysaccharide (LPS) and interferon gamma. In human hepatocytes, NOS activity induced treatment with combination tumor necrosis factor, interleukin 1, gamma, LPS. We now report the molecular cloning expression hepatocyte (hep-NOS) cDNA. hep-NOS has 80% amino acid sequence homology to macrophage (mac-NOS). Like other isoforms,...
Nitric oxide (NO.) is a short-lived mediator which can be induced in variety of cell types and produces many physiologic metabolic changes target cells. The inducible or high-output NO. synthase (NOS) pathway was first characterized macrophages activated by lipopolysaccharide (LPS) interferon gamma (IFN-gamma). Hepatocytes also express an NOS following exposure to the combination endotoxin tumor necrosis factor (TNF), interleukin 1 (IL-1), IFN-gamma. In this study, identify these cytokines,...
BackgroundIn the ongoing phase I PROFILE 1001 study, crizotinib showed antitumor activity in patients with ROS1-rearranged advanced non-small-cell lung cancer (NSCLC). Here, we present updated activity, overall survival (OS) and safety data (additional 46.2 months follow-up) for NSCLC from 1001.Patients methodsROS1 status was determined by FISH or reverse transcriptase–polymerase chain reaction. All received at a starting dose of 250 mg twice daily.ResultsFifty-three crizotinib, median...
Abstract Measurements of skeletal muscle cross-sectional area, index, and radiation attenuation utilizing clinical computed tomography (CT) scans are used in assessments sarcopenia, the loss mass function associated with aging. To classify individuals as sarcopenic, sex-specific cutoffs for ‘low’ values used. Conventionally, measurements at level third lumbar (L3) vertebra used, however L3 is not included several CT protocols. Non-contrast-enhanced from healthy kidney donor candidates (age...
Lipopolysaccharide (LPS) binding protein (LBP) is a key serum factor that mediates LPS activation of mononuclear cells. In the presence LBP, 1/1,000 concentration sufficient to activate peripheral blood monocytes. Previous studies with Kupffer cells have shown variable effect on these and led conclusion that, unlike extrahepatic cells, do not respond in an LBP-dependent fashion. Because there are multiple components other than LBP might affect activation, reports difficult interpret. To...
Background: The pattern and severity of crash injury depends on a complex interaction biomechanical factors such as deceleration velocity at impact (delta-V), seat-belt airbag use, type impact. Human body characteristics height weight may play an important role. We hypothesized that mass index (BMI) will influence patterns. Methods: University Michigan Program for Injury Research Education database was queried. Three cohorts were analyzed, lean (BMI ≤ 25 kg/m2), overweight 25-30 obese > 30...
Assess the relationship between lean core muscle size, measured on preoperative cross-sectional images, and surgical outcomes.Novel measures of risk are needed. Analytic morphomic analysis diagnostic images may elucidate vast amounts patient-specific data, which never assessed by clinicians.The study population included all patients within Michigan Surgical Quality Collaborative database with a computerized tomography(CT) scan before major, elective general or vascular surgery (N = 1453)....
The human body undergoes a variety of changes as it ages through adulthood. These include both morphological (structural) (e.g., increased thoracic kyphosis) and material osteoporosis). purpose this study is to evaluate structural that occur in the aging bony thorax assess importance these relative well-established changes. involved two primary components. First, full-thorax computed tomography (CT) scans 161 patients, age 18 89 years, were analyzed quantify angle ribs sagittal plane. A...
Sarcopenia, defined as a decrease in skeletal muscle mass and strength, is an important risk factor clinical medicine associated with frailty, mortality, worse surgical nonsurgical outcomes. Conventional measures of sarcopenia rely on the subjective "eyeball test" do not adequately describe risk. Computed tomography (CT) imaging studies may be used to objectively measure for stratification identification patients inclusion novel remediation program.We results observed general, vascular,...
Heterotopic ossification induced by injuries and burns is mediated signaling through the SMAD pathway can be targeted with topical apyrase.
Sarcopenia is defined as the loss of skeletal muscle mass and function associated with aging. Muscle can be reliably accurately quantified using clinical CT scans but reference measurements are lacking, particularly in healthy US populations. Two-phase from kidney donors (age 18-40) at University Michigan between 1999-2010 were utilized. was two thoracic lumbar cross-sectional area (CSA) measures. Indexed computed divided by height-squared. Paired analyses non-contrast contrast phases...
Preoperative risk assessment, particularly for patient frailty, remains largely subjective. This study evaluated the relationship between core muscle size and outcomes following esophagectomy malignancy. Using preoperative computed tomography scans in 230 subjects who had undergone transhiatal cancer 2001 2010, lean psoas area (LPA), measured at fourth lumbar vertebra, was determined. Cox proportional hazards regression employed to analyze overall survival (OS) disease-free (DFS) adjusted...
Defective cardiac function during sepsis has been referred to as “cardiomyopathy of sepsis.” It is known that leads intensive activation the complement system. In current study, and cardiomyocyte contractility have evaluated in rats after cecal ligation puncture (CLP). Significant reductions left ventricular pressures occurred vivo vitro. These defects were prevented CLP given blocking antibody C5a. Both mRNA protein for C5a receptor (C5aR) constitutively expressed on cardiomyocytes; both...
No AccessJournal of Urology1 Dec 1988A Bladder Pressure Management System for Myelodysplasia—Clinical Outcome Stephen C. Wang, Edward J. McGuire, and David A. Bloom WangStephen Wang More articles by this author , McGuireEdward McGuire BloomDavid View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)42084-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail A program the management neurogenic bladder in patients with...