A5062372145- Statistical Methods and Inference
- Statistical Methods and Bayesian Inference
- Advanced Causal Inference Techniques
- Dialysis and Renal Disease Management
- Healthcare Policy and Management
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Kidney Disease and Diabetes
- Acute Ischemic Stroke Management
- Statistical Methods in Clinical Trials
- Gene expression and cancer classification
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Mast cells and histamine
- Machine Learning in Healthcare
- Genetic Associations and Epidemiology
- Healthcare Systems and Reforms
- Bayesian Methods and Mixture Models
- Blood Pressure and Hypertension Studies
- Genetic and phenotypic traits in livestock
- COVID-19 epidemiological studies
- Radiomics and Machine Learning in Medical Imaging
- Obstructive Sleep Apnea Research
- Cytokine Signaling Pathways and Interactions
- Insurance, Mortality, Demography, Risk Management
- Potassium and Related Disorders
University of Michigan
2016-2025
Michigan United
2018-2024
Blueprint Medicines (United States)
2020-2024
Charles River Laboratories (Netherlands)
2024
University of Chicago
2023
Princess Margaret Cancer Centre
2023
Michigan Medicine
2011-2023
University of Iowa
2023
University of Pennsylvania
2023
John Wiley & Sons (United States)
2018-2020
Background: Patients with end-stage kidney disease (ESKD) on dialysis were excluded from clinical trials of direct oral anticoagulants for atrial fibrillation (AF). Recent data have raised concerns regarding the safety dabigatran and rivaroxaban, but apixaban has not been evaluated despite current labeling supporting its use in this population. The goal study was to determine patterns associated outcomes dialysis-dependent patients ESKD AF. Methods: We performed a retrospective cohort...
BACKGROUND: Few population-based studies have assessed sex differences in stroke recurrence. In addition, contributors to recurrence and poststroke mortality, including social factors, are unclear. We investigated these outcomes the contribution of social, clinical, behavioral factors differences. METHODS: First-ever ischemic cases identified from 2008 2019 Brain Attack Surveillance Corpus Christi Project Texas were included followed for all-cause mortality through 2020. Sex with without...
Assess the relationship between lean core muscle size, measured on preoperative cross-sectional images, and surgical outcomes.Novel measures of risk are needed. Analytic morphomic analysis diagnostic images may elucidate vast amounts patient-specific data, which never assessed by clinicians.The study population included all patients within Michigan Surgical Quality Collaborative database with a computerized tomography(CT) scan before major, elective general or vascular surgery (N = 1453)....
Early detection of potential depression among elderly people is conducive for timely preventive intervention and clinical care to improve quality life. Therefore, prediction considering sequential progression patterns in needs be further explored.We selected 1,538 from Chinese Longitudinal Healthy Longevity Study (CLHLS) wave 3-7 survey. Long short-term memory (LSTM) six machine learning (ML) models were used predict different risk factors the risks population next two years. Receiver...
Chronic kidney disease (CKD) leads to end-stage renal failure and cardiovascular events. An attribute these progressions is abnormalities in inflammation, which can be evaluated using the neutrophil-to-lymphocyte ratio (NLR). We aimed investigate association of NLR with progression end stage (ESRD), (CVD) all-cause mortality Chinese patients stages 1-4 CKD.Patients CKD (18-74 years age) were recruited at 39 centers 28 cities across 22 provinces China since 2011. A total 938 complete other...
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Prognostic models are useful tools for assessing a patient's risk of experiencing adverse health events. In practice, these must be validated before implementation to ensure that they clinically useful. The concordance index (C‐Index) is popular statistic used model validation, and it often applied with binary or survival outcome variables. this paper, we summarize existing criticism the C‐Index show many limitations accentuated when outcomes, continuous outcomes more generally. We present...
IntroductionChronic kidney disease (CKD) is an important noncommunicable globally. Overall prevalence of CKD and distribution its stages differ between countries. We postulate that these differences may not only be due to variation in risk factors but also their differential impact different populations or settings.MethodsWe used nationally representative data on the adult from both United States (US; National Health Nutrition Examination Survey [NHANES], 2009 2010, N = 5557) China (China...
1056 Background: CDK2 is implicated in CDK4/6 inhibitor (CDK4/6i) resistance hormone receptor-positive/human epidermal growth factor receptor-2–negative (HR+/HER2−) BC. In addition, amplification and overexpression of cyclin E1 gene ( CCNE1), which leads to hyperactivation E/CDK2 dependence, associated with shorter survival multiple aggressive cancers. inhibition thus an attractive novel anticancer approach. BLU-222 investigational, oral, potent, selective CDK2i clinical development showing...
Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which 70% of patients experience disfiguring skin inflammation (grouped under the rubric cutaneous [CLE]). There are limited treatment options for SLE and no Food Drug Administration-approved therapies CLE. Studies have revealed that IFNs important mediators CLE, but mechanisms by lead to still poorly understood. We aimed investigate how IFN responses keratinocytes contribute development A cohort 72 RNA sequencing samples...
Measurement quality assurance (QA) practices play a key role in the safe use of Intensity Modulated Radiation Therapies (IMRT) for cancer treatment. These have reduced measurement-based IMRT QA failure below 1%. However, these are time and labor intensive which can lead to delays patient care. In this study, we examine how conformal prediction methodologies be used robustly triage plans. We propose new training-aware risk control method by combining benefit training. incorporate decision...
Extensive literature has been proposed for the analysis of correlated survival data. Subjects within a cluster share some common characteristics, e.g., genetic and environmental factors, so their time-to-event outcomes are correlated. The frailty model under proportional hazards assumption widely applied clustered outcomes. However, prediction performance this method can be less satisfactory when risk factors have complicated effects, nonlinear interactive. To deal with these issues, we...
Uromodulin is specifically synthesized and secreted by kidney tubular epithelial cells. Studies on the association of serum uromodulin outcomes chronic disease (CKD) are lacking. This study aimed to evaluate whether was associated with patients CKD.We measured concentrations ELISA in 2652 CKD from Chinese Cohort Study Chronic Kidney Disease (C-STRIDE) investigated patients, including end-stage (ESKD) receiving replacement therapy, cardiovascular events mortality Cox proportional hazards...