A5101464916- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Chronic Kidney Disease and Diabetes
- Hormonal Regulation and Hypertension
- Dialysis and Renal Disease Management
- Renal and related cancers
- Parathyroid Disorders and Treatments
- Inflammasome and immune disorders
- Ion Transport and Channel Regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Acute Kidney Injury Research
- Cancer, Hypoxia, and Metabolism
- Sarcoidosis and Beryllium Toxicity Research
- MicroRNA in disease regulation
- Mast cells and histamine
- T-cell and B-cell Immunology
- Psoriasis: Treatment and Pathogenesis
- Sodium Intake and Health
- Renal cell carcinoma treatment
- NF-κB Signaling Pathways
- Single-cell and spatial transcriptomics
- Heme Oxygenase-1 and Carbon Monoxide
Xiangya Hospital Central South University
2015-2024
Central South University
2015-2024
Sichuan Provincial Architectural Design and Research Institute (China)
2023
Fujian Agriculture and Forestry University
2011-2020
Zhejiang University
2019-2020
China Jiliang University
2020
Gansu Provincial Center for Disease Control and Prevention
2017
Shantou University
2016
Shantou University Medical College
2016
North Bristol NHS Trust
2015
Chronic kidney disease (CKD) leads to end-stage renal failure and cardiovascular events. An attribute these progressions is abnormalities in inflammation, which can be evaluated using the neutrophil-to-lymphocyte ratio (NLR). We aimed investigate association of NLR with progression end stage (ESRD), (CVD) all-cause mortality Chinese patients stages 1-4 CKD.Patients CKD (18-74 years age) were recruited at 39 centers 28 cities across 22 provinces China since 2011. A total 938 complete other...
The mammalian collecting duct comprises principal and intercalated cells, which maintain sodium/water acid/base balance, respectively, but the epigenetic contributors to differentiation of these cell types remain unknown. Here, we investigated whether histone H3 K79 methyltransferase Dot1l, is highly expressed in participates this process. Taking advantage distribution aquaporin 2 (Aqp2), localizes cells duct, developed mice lacking Dot1l Aqp2-expressing (Dot1lAC) found that had...
Renal injury has a strong relationship to the subsequent development of renal fibrosis. In developing fibrosis, tubular epithelial cells in kidney underwent epithelial–mesenchymal transition (EMT). Matrix metalloproteinase 7 (MMP7) was reported reduce E-cadherin and induce EMT by up-regulation β-catenin/lymphoid enhancer-binding factor 1 (LEF1) signaling. this research, we tried evaluate role resveratrol (RSV) on process Human cell HK-2 were treated with aristolochic acid (AAs) transforming...
Abstract Since December 2019, a novel coronavirus named 2019 (2019-nCoV) has emerged in Wuhan of China and spread to several countries worldwide within just one month. Apart from fever respiratory complications, acute kidney injury been observed some patients with 2019-nCoV. In short period time, angiotensin converting enzyme II (ACE2), have proposed serve as the receptor for entry 2019-nCoV, which is same severe syndrome (SARS). To investigate possible cause damage 2019-nCoV patients, we...
The molecular mechanisms underlying renal damage of IgA nephropathy (IgAN) remain incompletely defined. Here, single-cell RNA sequencing (scRNA-seq) was applied to kidney biopsies from IgAN and control subjects define the transcriptomic landscape at resolution. We presented a comprehensive scRNA-seq analysis human IgAN. showed for first time that mesangial cells displayed increased expression several novel genes including MALAT1, GADD45B, SOX4, EDIL3, which were related cell proliferation...
Abstract Background: Since 2019, a novel coronavirus named 2019 (2019-nCoV) has emerged worldwide. Apart from fever and respiratory complications, acute kidney injury been observed in few patients with disease 2019. Furthermore, according to recent findings, the virus detected urine. Angiotensin-converting enzyme II (ACE2) proposed serve as receptor for entry of 2019-nCoV, which is same that severe syndrome. This study aimed investigate possible cause damage potential route 2019-nCoV...
Cardiovascular and renal inflammation induced by Aldosterone (Aldo) plays an important role in the pathogenesis of hypertension fibrosis. Toll-like receptor 4 (TLR4) signaling contributes to inflammatory cardiovascular diseases, but its Aldo-induced damage is not clear. In current study, rats were treated with Aldo-salt combined TAK-242 (a TLR4 antagonist) for weeks. Hemodynamic, cardiac parameters assayed at indicated time. We found that Aldo-salt-treated present hypertrophy dysfunction....
Dot1l encodes histone H3 K79 methyltransferase Dot1a. Mice with deficiency in renal Aqp2-expressing cells (Dot1lAC) develop polyuria by unknown mechanisms. Here, we report that Aqp5 links deletion to through Aqp2. cDNA array analysis revealed and real-time RT-qPCR validated as the most upregulated gene Dot1lAC vs. control mice. protein is barely detectable controls, but robustly expressed kidneys, where it colocalizes The upregulation of coupled reduced association Dot1a dimethyl specific...
Background and Purpose Liver diseases are mostly accompanied by inflammation hepatocyte death. Therapeutic approaches targeting both injury not available. Natural compounds considered as potential treatment for inflammatory liver diseases. Hesperetin, a flavonoid component of citrus fruits, has been reported to have anti‐inflammatory properties. The aim this study was evaluate the cytoprotective properties hesperetin in vitro models fulminant hepatitis. Experimental Approach Apoptotic cell...
Objective: With limited data available on calcification prevalence in chronic kidney disease (CKD) patients dialysis, the China Dialysis Calcification Study (CDCS) determined of vascular/valvular (VC) and association risk factors Chinese with prevalent hemodialysis (HD) or peritoneal dialysis (PD).Methods: CKD undergoing HD/PD for ≥6 months were enrolled. Prevalence medical history documented at baseline. Coronary artery (CAC) was assessed by electron beam multi-slice computed tomography...
Chronic kidney disease (CKD) has been considered as a major health problem in the world. Increasing uric acid (UA) could induce vascular endothelial injury, which is closely related to microinflammation, oxidative stress, and disorders of lipids metabolism. However, specific mechanism that UA induces cells injury early CKD remains unknown. Human umbilical vein (HUVECs) were cultured subjected different concentrations for periods. Early rat model with elevated serum was established. Western...
Rapidly progressive glomerulonephritis caused by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is typically characterized as pauci-immune glomerulonephritis. However, immune complex (IC) deposition in the glomerulus has been reported a growing number of studies. Here, we assess presence glomerular deposits alongside renal outcome myeloperoxidase (MPO)-ANCA associated (MPO-ANCA GN). Clinical and histopathologic characteristics 97 patients with MPO-ANCA GN classified...
Idiopathic membranous nephropathy (IMN) is an organ-specific autoimmune disease of the kidney glomerulus. It may gradually progress to end-stage renal (ESRD) characterized by increased proteinuria, which leads serious consequences. Although substantial advances have been made in understanding molecular bases IMN last 10 years, certain questions remain largely unanswered. To define transcriptomic landscape at single-cell resolution, we analyzed samples from 6 patients with anti-PLA2R positive...
This study aims to investigate the role of Notch pathway in renal ischemia/reperfusion injury (IRI)-associated inflammation and apoptosis.Male Sprague-Dawley rats were divided into three groups: normal saline (NS)-treated sham rats, NS-treated (I/R) N-[N-(3,5-difluorophenacetyl-l-alanyl)]-S-phenylglycine t-butyl ester (DAPT) (a γ-secretase inhibitor) treated I/R rats. rat model underwent nephrectomy right kidney was subjected 60 min left pedicle occlusion followed by 24 h, 48 72 h...
Grain chalkiness is an important grain quality related to starch granules in the endosperm. A high percentage of a major problem because it diminishes rice. Here, we report quantitative trait loci identification for using high-throughput single nucleotide polymorphism genotyping chromosomal segment substitution line population which each carried one or few introduced japonica cultivar Nipponbare segments genetic background indica ZS97. Ten regions were commonly identified and degree...
Chlorantraniliprole, an anthranilic diamide insecticide, is widely used for controlling lepidopteran pests, because of its high insecticidal activity. However, overuse chlorantraniliprole has led to the selection resistance in many insect including Chilo suppressalis (Lepidoptera:Crambidae), one most damaging rice pests China. In this study, levels C. was surveyed from eight populations three provinces The were ranged 34.4-fold 284.0-fold compared with a susceptible population. Then, 15402...
We previously reported that Dot1a.AF9 complex represses transcription of the epithelial Na(+) channel subunit alpha (alpha-ENaC) gene in mouse inner medullary collecting duct mIMCD3 cells and kidney. Aldosterone relieves this repression by down-regulating through various mechanisms. Whether these mechanisms are sufficient conserved human or can be applied to other aldosterone-regulated genes remains largely unknown. Here we demonstrate embryonic kidney 293T express three ENaC subunits all...
The existing therapies of IgA nephropathy are unsatisfying. Acteoside, the main component Rehmannia glutinosa with anti-inflammatory and anti-immune effects, can improve urinary protein excretion immune disorder. Th22 cell is involved in progression. This study was determined to explore effect acteoside on mesangial injury underlying disorder nephropathy. Serum cells urine total patients were measured before after six months treatment or valsartan. Chemotactic assay co-culture performed...
Purpose: Morbidity associated with and mortality from acute kidney injury (AKI) is gradually increasing, no efficient drug available. We explored whether neferine, a bisbenzylisoquinoline alkaloid, attenuated AKI, the possible mechanisms in play vivo vitro. Methods: induced AKI using ischemia-reperfusion (I/R) or lipopolysaccharide (LPS) vivo. C57 BL/6 male mice were randomized into two groups each containing four subgroups: control, I/R LPS, LPS + neferine. Mice sacrificed 24 h after...