A5082678959- Gout, Hyperuricemia, Uric Acid
- Advanced Polymer Synthesis and Characterization
- Parathyroid Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Paraquat toxicity studies and treatments
- Dialysis and Renal Disease Management
- Heme Oxygenase-1 and Carbon Monoxide
- Polymer Surface Interaction Studies
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Advanced Thermoelectric Materials and Devices
- biodegradable polymer synthesis and properties
- Renal Diseases and Glomerulopathies
- Electromagnetic wave absorption materials
- Thermal properties of materials
- Advanced Glycation End Products research
- Advanced Antenna and Metasurface Technologies
- MRI in cancer diagnosis
- Chemotherapy-induced organ toxicity mitigation
- Tea Polyphenols and Effects
- Hepatitis C virus research
- Gut microbiota and health
- Case Reports on Hematomas
- Hemoglobinopathies and Related Disorders
- Hormonal Regulation and Hypertension
Guizhou University
2023-2025
Liaoning Technical University
2023-2024
Shanghai Tenth People's Hospital
2015-2024
China National Petroleum Corporation (China)
2024
Sichuan University
2023
West China Hospital of Sichuan University
2023
Tongji University
2014-2023
Wolfson Medical Center
2022
Tel Aviv University
2022
Harbin Engineering University
2021
Abstract Background Chronic kidney disease (CKD) is a severe public health problem associated with disordered gut microbiome. However, the functional alterations of microbiota and their cross talk metabolism pathways based on severity remain unclear. Results We performed metagenomics untargeted metabolomics in cohort 68 patients CKD differing severities 20 healthy controls to characterize complex interplay between microbiome fecal serum metabolites during progression. identified 26 microbial...
Baseline findings from the China Dialysis Calcification Study (CDCS) revealed a high prevalence of vascular calcification (VC) among patients with end-stage kidney disease; however, data on VC progression were limited. To understand at different anatomical sites, identify risk factors for progression, and assess association cardiovascular events death receiving maintenance dialysis. This cohort study was 4-year follow-up assessment participants in CDCS, nationwide multicenter prospective...
This was the first multicenter, cross-sectional survey to assess prevalence of anemia, patient awareness, and treatment status in China. Data patients with chronic kidney disease (CKD; age, 18–75 years; both out- inpatients) from 25 hospitals Shanghai, seeking medical at nephrology department, were collected between July 1, 2012 August 31, 2012. The prevalence, anemia nondialysis CKD (ND-CKD) assessed. Anemia defined as serum hemoglobin (Hb) levels ·12 g/dL women ·13 men. A total 2420 ND-CKD...
Evidence suggests that glycogen synthase kinase 3β (GSK3β) contributes to AKI; however, its role in post-AKI kidney repair remains uncertain. Here, delayed treatment with a single dose of lithium, selective inhibitor GSK3β and US Food Drug Administration-approved mood stabilizer, accelerated recovery renal function, promoted repopulation tubular epithelia, improved murine models cisplatin- ischemia/reperfusion-induced AKI. These effects associated reduced activity elevated expression...
As a prominent feature of gout, monosodium urate (MSU) crystal deposition induces gout flares, but its impact on immune inflammation in remission remains unclear. Using single-cell RNA sequencing (scRNA-seq), we characterize the transcription profiling peripheral blood mononuclear cells (PBMCs) among intercritical advanced and normal controls. We find systemic with MSU at stages, evidenced by activated inflammatory pathways, strengthened cell-cell interactions, elevated arachidonic acid...
The aim of this study was to investigate the clinical significance real-time gray-scale contrast-enhanced ultrasound (CEUS) through evaluating renal microvascular perfusion in diabetic kidney damage.Diabetic patients (aged: 62.5±7.2, n=33) were divided into Group A with chronic disease (CKD) Stages I and II (n=19) B (n=14) CKD IV V. Twenty-one healthy adults selected as control group. dynamic imaging from cortex performed using SonoVue. outage time-intensity curves (TICs) >85%...
Background Dysregulaiton of phosphate homeostasis as occurs in chronic kidney disease is associated with cardiovascular complications. It has been suggested that both hyperphosphatemia and hypophosphatemia can cause disease. The molecular mechanisms by which high or low serum levels adversely affect function are poorly understood. purpose this study was to explore the endothelial dysfunction presence non-physiologic levels. Methodology/Principal Findings We studied effects simulated hyper-...
NOD-like receptor family caspase recruitment domain containing 5 (NLRC5) has important roles in inflammation and innate immunity. NLRC5 was highly expressed kidney from streptozotocin-induced diabetic mice, db/db mice patients with diabetes. Based on that evidence, the present study designed to explore of progression nephropathy (DN). We examined injury, including fibrosis Nlrc5 gene knockout (Nlrc5−/−) wild-type (WT) mice. found Nlrc5−/− developed less-severe injury compared WT exhibiting...
Objective: With limited data available on calcification prevalence in chronic kidney disease (CKD) patients dialysis, the China Dialysis Calcification Study (CDCS) determined of vascular/valvular (VC) and association risk factors Chinese with prevalent hemodialysis (HD) or peritoneal dialysis (PD).Methods: CKD undergoing HD/PD for ≥6 months were enrolled. Prevalence medical history documented at baseline. Coronary artery (CAC) was assessed by electron beam multi-slice computed tomography...
Crescentic glomerulonephritis (GN) is the most severe form of GN and associated with significant morbidity mortality despite aggressive immunotherapy steroids, cytotoxic drugs, plasmapheresis. We examined therapeutic efficacy green tea polyphenol (−)-epigallocatechin-3-gallate (EGCG, 50 mg/kg BW/day x3weeks), a potent anti-inflammatory anti-oxidant agent, on experimental crescentic induced in 129/svJ mice by administration rabbit anti-mouse glomerular basement membrane sera. Routine...
Acute kidney injury (AKI) causes severe morbidity and mortality for which new therapeutic strategies are needed. Docosahexaenoic acid (DHA), arachidonic (ARA), their metabolites have various effects in injury, but molecular mechanisms largely unknown. Here, we report that 14 (15)-epoxyeicosatrienoic [14 (15)-EET] 19 (20)-epoxydocosapentaenoic [19 (20)-EDP], the major epoxide of ARA DHA, respectively, contradictory on a murine model ischemia/reperfusion (I/R)-caused AKI. Specifically,...
Converging evidence points to glycogen synthase kinase (GSK) 3 as a key player in the pathogenesis of podocytopathy and proteinuria. However, it remains unclear if GSK3 is involved podocyte autonomous injury glomerular disease. In normal kidneys, β isoform was found be major expressed glomeruli intensely stained podocytes. GSK3β expression podocytes markedly elevated experimental or human proteinuric glomerulopathy. Podocyte-specific somatic ablation adult mice attenuated proteinuria...
Abstract Background The global reputation of coronavirus disease (COVID-19) has led universities in China to conduct online teaching. However, the actual feedback from medical teachers and students regarding education remains unclear. Methods A prospective questionnaire survey examined current opinions at Medical School Tongji University. Results total 488 valid questionnaires were collected (223 males, 45.7%; 265 females, 54.3%), including 394 (80.7%) 94 (19.3%). Most “in favor teaching,”...
OBJECTIVE: To determine the proportion of correct emergency department (ED) diagnoses and hospital discharge diagnoses, in comparison with final at end a 30-day follow-up, patients presenting nonspecific complaints (NSCs) to ED; differences between male female missed diagnoses. METHODS: Prospective observational study. Diagnoses made ED, were compared. RESULTS: Of 22,782 nontrauma ED from May 2007 until 2009, 9,926 triaged as severity index level 2 or 3, whom 789 presented NSCs. After...