A5055800649- Renal Diseases and Glomerulopathies
- Pain Mechanisms and Treatments
- Organ Transplantation Techniques and Outcomes
- Chronic Kidney Disease and Diabetes
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroscience and Neuropharmacology Research
- Magnesium in Health and Disease
- MicroRNA in disease regulation
- Phytoestrogen effects and research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Dermatology and Skin Diseases
- Blood Pressure and Hypertension Studies
- Spinal Fractures and Fixation Techniques
- Alzheimer's disease research and treatments
- Parathyroid Disorders and Treatments
- Acute Kidney Injury Research
- Liver Disease and Transplantation
- Adenosine and Purinergic Signaling
- Lipoproteins and Cardiovascular Health
- Mitochondrial Function and Pathology
- Spinal Cord Injury Research
- Inflammasome and immune disorders
The University of Texas Southwestern Medical Center
2002-2024
Zunyi Medical University
2023-2024
Chinese PLA General Hospital
2001-2024
Chengdu Medical College
2024
Chengdu University
2024
Shandong University
2014-2022
Sun Yat-sen University
2016-2022
Shandong Provincial QianFoShan Hospital
2022
Shandong First Medical University
2022
The First Affiliated Hospital, Sun Yat-sen University
2016-2022
Abstract Chronic kidney diseases have become a major issue worldwide. The spectrum of biopsy proven renal differs between locations and changes over time. It is therefore essential to describe the local epidemiological trends prevalence in various regions shine new light on pathogenesis provide basis for further hypothesis-driven research. We retrospectively analyzed 34,630 hospitalized patients undergoing native January 1, 2009 December 31, 2018. Indications histological diagnosis were...
Spinal cord injury (SCI) represents a relatively common type of motor system trauma. While the SCI patient will experience varying degrees paraplegia and quadriplegia, which severely affects their quality life, heavy burden is also placed on family society as whole. The exact pathogenic mechanisms underlying this condition remain unknown no specific treatments are currently available. Findings from recent studies have shown that mesenchymal stem cells (MSCs), derived extracellular vesicles...
The effect of reactive oxygen species (ROS) on nitric oxide synthase (NOS) expression remains uncertain. This study explored the increased ROS activity NOS in vitro human coronary artery endothelial cells (HCAECs) grown culture and intact animals.Endothelial (eNOS) nuclear factor kappaB (NFkappaB) activation were determined HCAECs exposed to oxidative stress with xanthine-xanthine oxidase (X-XO) generated superoxide, H(2)O(2), or glutathione depletion buthionine sulfoximine (BSO) for 24 h....
Purpose: Spinal cord injury (SCI) is a relatively common, devastating traumatic condition resulting in permanent disability. In this study, the use of exosomes derived from bone mesenchymal stem cells (BMSCs-Exo) as cell-free therapy for treatment SCI rats was investigated to gain insights into their mechanisms action. Methods: Rats were randomly divided three groups, Sham (treated with PBS), (SCI + PBS) and Exo BMSCs-Exo). Changes complement system between groups assessed proteomics. The...
Abstract Background Bladder-related pain symptoms in patients with bladder syndrome/interstitial cystitis (BPS/IC) are often accompanied by depression and memory deficits. Magnesium deficiency contributes to neuroinflammation is associated pain, depression, Neuroinflammation involved the mechanical allodynia of cyclophosphamide (CYP)-induced cystitis. Magnesium-L-Threonate (L-TAMS) supplementation can attenuate neuroinflammation. This study aimed determine whether how L-TAMS influences...
Background Dysregulaiton of phosphate homeostasis as occurs in chronic kidney disease is associated with cardiovascular complications. It has been suggested that both hyperphosphatemia and hypophosphatemia can cause disease. The molecular mechanisms by which high or low serum levels adversely affect function are poorly understood. purpose this study was to explore the endothelial dysfunction presence non-physiologic levels. Methodology/Principal Findings We studied effects simulated hyper-...
Receptor‐interacting protein 3‐ (RIPK3‐) modulated necroptosis plays a critical role in cardiac remodelling after myocardial infarction (MI). However, the precise regulatory mechanism is not fully elucidated yet. In present study, we showed that RIPK3 expression was upregulated tissue MI mouse model by coronary artery ligation, as well cardiomyocytes following hypoxic injury vitro . The increase of found to be accompanied severe remodelling, dysfunction, and higher mortality. Elevated...
Abstract Aims This study aimed to investigate whether electroacupuncture (EA) promotes the survival and synaptic plasticity of hippocampal neurons by activating brain‐derived neurotrophic factor (BDNF)/tyrosine receptor kinase (TrkB)/extracellular signal‐regulated (Erk) signaling, thereby improving spatial memory deficits in rats under SD. Methods In vivo, Morris water maze (MWM) was used detect effect EA on learning memory, at same time Western blotting (WB), immunofluorescence (IF),...
Abstract Background Not many large‐sample investigations are available that compare the potency of relationship remnant cholesterol (RC) and other lipid parameters with diabetes prediabetes. The goals our study to discover between RC prediabetes, diabetes, insulin resistance (IR) investigate RC, high‐density lipoprotein (HDL‐C), non‐HDL‐C, triglycerides (TG), low‐density (LDL‐C), total (TC), TC/HDL‐C, LDL‐C/HDL‐C, TG/HDL‐C, which most positively related IR. Methods This research enrolled 36...
Objective. Vascular cell adhesion molecule-1 (VCAM-1), an molecule, is involved in the progression of glomerular and tubulointerstitial injury. Neutrophil gelatinase-associated lipocalin (NGAL), a member superfamily, has been shown to rise both acute chronic kidney damage. Both VCAM-1 NGAL have found at high levels urine patients with active lupus nephritis. We investigated as potential biomarkers for Methods. were measured by ELISA during 1 8 clinic visits 107 systemic erythematosus (SLE;...
Increasing evidence suggests that epilepsy is the result of synaptic reorganization and pathological excitatory loop formation in central nervous system; however, mechanisms regulate this process are not well understood. We proposed microRNA-132 (miR-132) p250GAP might play important roles by activating downstream Rho GTPase family. tested hypothesis using a magnesium-free medium-induced epileptic model cultured hippocampal neurons. investigated whether miR-132 regulates activity through...
Previous studies have shown that resveratrol, a bioactive substance found in many plants, can reduce early brain injury after subarachnoid hemorrhage, but how it acts is still unclear. This study explored the mechanism using experimental hemorrhage rat model established by injecting autologous blood into cerebellomedullary cistern. Rat models were treated with an intraperitoneal injection of 60 mg/kg resveratrol 2, 6, 24 and 46 hours injury. At 48 injury, their neurological function was...
Abstract: Background: Steatosis significantly contributes to an organ's transplantability. Livers with >30% fat content have a 25% chance of developing primary non‐function (PNF). The current practice evaluating hematoxylin and eosin (H&E) stained donor biopsy by visual interpretation is subjective. We hypothesized that H&E staining frozen sections fails accurately estimate the degree steatosis present within given liver biopsy. To address this problem in prospective organs, we...