A5101828865- Spaceflight effects on biology
- Antimicrobial Resistance in Staphylococcus
- Genomics and Phylogenetic Studies
- Antibiotic Resistance in Bacteria
- Planetary Science and Exploration
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Obstructive Sleep Apnea Research
- Space Exploration and Technology
- Nosocomial Infections in ICU
- Polar Research and Ecology
- Mycobacterium research and diagnosis
- Lung Cancer Treatments and Mutations
- Bacteriophages and microbial interactions
- Infections and bacterial resistance
- Sepsis Diagnosis and Treatment
- RNA modifications and cancer
- Probiotics and Fermented Foods
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- Space Science and Extraterrestrial Life
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
Chinese PLA General Hospital
2014-2025
National Clinical Research
2021
Chinese People's Liberation Army
2006-2021
Creative Commons
2017
Wu Jieping Medical Foundation
2017
People's Liberation Army No. 150 Hospital
2006-2015
Southwest Hospital
2011
Army Medical University
2011
Woodward (United States)
2008
BackgroundAzvudine and nirmatrelvir/ritonavir are approved to treat mild-to-moderate coronavirus disease 2019 (COVID-19) in adults with a high risk for progression severe infection. We sought compare the antiviral effectiveness clinical outcomes of elderly patients COVID-19 receiving these two agents.MethodsIn this observational study, we identified 249 infection who were admitted Second Medical Center People's Liberation Army General Hospital from December 2022 January 2023, including 128...
Receptor‐interacting protein 3‐ (RIPK3‐) modulated necroptosis plays a critical role in cardiac remodelling after myocardial infarction (MI). However, the precise regulatory mechanism is not fully elucidated yet. In present study, we showed that RIPK3 expression was upregulated tissue MI mouse model by coronary artery ligation, as well cardiomyocytes following hypoxic injury vitro . The increase of found to be accompanied severe remodelling, dysfunction, and higher mortality. Elevated...
ABSTRACT This study aims to identify the risk factors associated with clinical outcomes and proteomic changes in organs related fatal SARS‐CoV‐2 infection within super‐elderly population. retrospective analysis included all elderly individuals COVID‐19 admitted Second Medical Center of PLA General Hospital from December 2022 January 2023. The follow‐up period ended on March 30, During this time, epidemiological, demographic, laboratory, outcome data were analyzed descriptively. Proteomic...
Abstract Background The concentrations of linezolid, its optimal regimen and the associated side effects in elderly patients remain unclear. Methods In this multicentre, prospective study, receiving linezolid at four tertiary hospitals Beijing between May 2021 December 2022 were included. Linezolid haematological toxicity monitored dynamically. Risk factors for overexposure moderate-to-severe linezolid-induced thrombocytopenia (M/S LIT) analysed, a predictive model M/S LIT was developed....
Acinetobacter baumannii has been reported increasingly as a significant causative organism of various nosocomial infections, including hospital-acquired pneumonia (HAP). The aim this study was to investigate the clinical characteristics HAP induced by carbapenem-resistant A. (CRAB) in elderly patients and vitro antimicrobial effects cefoperazone/sulbactam combination therapy.Seventy-one geriatric ward General Hospital People's Liberation Army (PLAGH) with CRAB-induced were analyzed...
Background: Hospital-acquired pneumonia (HAP) due to Achromobacter has become a substantial concern in recent years. However, HAP the elderly is rare. Methods: A retrospective analysis was performed on 15 patients with spp., which sequence types (STs), integrons, biofilm production and antibiotic resistance of spp. were examined. Results: The mean age 88.8±5.4 All had at least 3 underlying diseases catheters. Clinical outcomes improved 10 after and/or mechanical ventilation treatment, but...
Evidence suggests that an increased risk of major adverse cardiac events (MACE) and all-cause mortality is associated with obstructive sleep apnea (OSA), particularly in the elderly. Metabolic syndrome (MetS) increases cardiovascular general population; however, less known about its influence patients OSA. We aimed to assess whether MetS affected MACE elderly OSA.From January 2015 October 2017, 1,157 OSA, aged ≥60 years, no myocardial infarction (MI), hospitalization for unstable angina or...
With the development of space science, it is important to analyze relationship between environment and genome variations that might cause phenotypic changes in microbes. Klebsiella pneumoniae commonly found on human body resistant multiple drugs. To study space-environment-induced drug resistance changes, K. was carried into outer by Shenzhou VIII spacecraft. The strain LCT-KP289 selected after spaceflight based its differences compared ground-control strain. Analysis genomic structural...
For a long time, Enterococcus faecium was considered harmless commensal of the mammalian gastrointestinal (GI) tract and used as probiotic in fermented foods. In recent decades, E. has been recognised an opportunistic pathogen that causes diseases such neonatal meningitis, urinary infections, bacteremia, bacterial endocarditis diverticulitis. could be taken into space with astronauts exposed to environment. Thus, it is necessary observe phenotypic molecular changes after spaceflight. An...
Klebsiella pneumoniae is a gram-negative, nonmotile, encapsulated, lactose-fermenting, facultative anaerobic, rod-shaped bacterium found in the normal flora of mouth, skin, and intestines. Here we present fine-draft genome sequence K. strain LCT-KP214, which originated from CGMCC 1.1736.
Pseudomonas aeruginosa is a common bacterium that can cause disease. The versatility of enables the organism to infect damaged tissues or those with reduced immunity which inflammation and sepsis. Here we report genome sequence strain ATCC 27853.