A5107772153- Mesenchymal stem cell research
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Cancer Cells and Metastasis
- Autophagy in Disease and Therapy
- Olfactory and Sensory Function Studies
- Epigenetics and DNA Methylation
- Neuroscience and Neural Engineering
- Virus-based gene therapy research
- MicroRNA in disease regulation
- Neurobiology and Insect Physiology Research
- SARS-CoV-2 and COVID-19 Research
- RNA Interference and Gene Delivery
- Tissue Engineering and Regenerative Medicine
- Metal complexes synthesis and properties
- Neural dynamics and brain function
- Mycobacterium research and diagnosis
- Biochemical Analysis and Sensing Techniques
- Hippo pathway signaling and YAP/TAZ
- Neuroinflammation and Neurodegeneration Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Drug Transport and Resistance Mechanisms
- Circular RNAs in diseases
- Spinal Cord Injury Research
- Tuberculosis Research and Epidemiology
University of Pennsylvania
2023-2025
Chinese PLA General Hospital
2014-2025
Wuxi People's Hospital
2020-2024
Nanjing Medical University
2020-2024
Shanghai Jiao Tong University
2023-2024
Shanghai First People's Hospital
2023-2024
Wannan Medical College
2019-2023
Affiliated Hospital of Guangdong Medical College Hospital
2023
Guangdong Medical College
2023
Jiangsu University
2013-2022
An ability to visualize HCN in mitochondria real time may permit additional insights into the critical toxicological and physiological roles this classic toxin plays living organisms. Herein, we report a mitochondria-specific coumarin pyrrolidinium-derived fluorescence probe (MRP1) that permits real-time ratiometric imaging of cells. The response is specific, sensitive (detection limit ca. 65.6 nM), rapid (within 1 s), reversible. Probe MRP1 contains benzyl chloride subunit designed enhance...
The initiation and progression of various solid tumors, including pancreatic carcinoma, are driven by a population cells with stem cell properties, namely cancer (CSCs). Like their normal counterparts, CSCs also believed to rely on own microenvironment termed niches sustain the population. Hypoxia-inducible factor-1α (HIF-1α) is major actor in survival response hypoxia. Recently, several researchers proposed that non-stem can convert stem-like maintain equilibrium. present study focuses...
Ferroptosis is a newly defined non-apoptotic programmed cell death resulting from the accumulation of lipid peroxides. Whether ferroptosis plays any role in chemotherapy remains to be established. Here, we reported that represents part chemotherapeutic drug etoposide-induced response Small Cell Lung Cancer (SCLC) cells and adaptive signaling molecule lactate protects Non-Small (NSCLC) ferroptosis. Lactate derived metabolic reprogramming increases expression glutathione peroxidase 4 (GPX4)...
BackgroundAzvudine and nirmatrelvir/ritonavir are approved to treat mild-to-moderate coronavirus disease 2019 (COVID-19) in adults with a high risk for progression severe infection. We sought compare the antiviral effectiveness clinical outcomes of elderly patients COVID-19 receiving these two agents.MethodsIn this observational study, we identified 249 infection who were admitted Second Medical Center People's Liberation Army General Hospital from December 2022 January 2023, including 128...
Glioblastoma (GBM), a universally fatal brain cancer, infiltrates the and can be synaptically innervated by neurons, which drives tumor progression 1-6 . Synaptic inputs onto GBM cells identified so far are largely short-range glutamatergic 7-9 The extent of integration into brain-wide neuronal circuitry is not well understood. Here we applied rabies virus-mediated retrograde monosynaptic tracing approach 10-12 to systematically investigate circuit human organoids transplanted adult mice. We...
Odor-preferences are usually influenced by life experiences. However, the neural circuit mechanisms remain unclear. The medial olfactory tubercle (mOT) is involved in both reward and olfaction, whereas ventral tegmental area (VTA) dopaminergic (DAergic) neurons considered to be engaged motivation. Here, we found that VTA (DAergic)-mOT pathway could activated different types of naturalistic rewards as well odors DAT-cre mice. Optogenetic activation VTA-mOT DAergic fibers was able elicit...
Abstract The therapeutic efficiency of allogenic/intrinsic neural stem cells (NSCs) after spinal cord injury is severely compromised because the hostile niche at lesion site incurs massive astroglial but not neuronal differentiation NSCs. Although many attempts are made to reconstruct a permissive for nerve regeneration, solely using living cell material build an all‐in‐one, multifunctional, promoting while inhibiting NSCs reported. Here, ectomesenchymal (EMSCs) reported serve as living,...
The piriform cortex (PC) is a key brain area involved in both processing and coding of olfactory information. It implicated various disorders, such as epilepsy, Alzheimer's disease autism. PC consists the anterior (APC) posterior (PPC) parts, which are different anatomically functionally. However, direct input networks to specific neuronal populations within APC PPC remain poorly understood. Here, we mapped whole-brain inputs two major populations, excitatory glutamatergic principal neurons...
ABSTRACT This study aims to identify the risk factors associated with clinical outcomes and proteomic changes in organs related fatal SARS‐CoV‐2 infection within super‐elderly population. retrospective analysis included all elderly individuals COVID‐19 admitted Second Medical Center of PLA General Hospital from December 2022 January 2023. The follow‐up period ended on March 30, During this time, epidemiological, demographic, laboratory, outcome data were analyzed descriptively. Proteomic...
Recombinant adeno-associated viruses (rAAVs), particularly those that permit efficient gene transfer to neurons from axonal terminals or across the blood-brain barrier, are useful vehicles for structural and functional studies of neural circuit treatment many gene-deficient brain diseases need compensate correct genes in every cell whole brain. However, AAVs with these two advantages have not been reported. Here, we describe a new capsid engineering method, which exploits combination...
Abstract The transplantation of tissue-engineered scaffolds with stem cells is a promising therapeutic approach for bone defect repair. To improve the efficacy this approach, in study, novel biofunctional live bone-like graft was designed and constructed using fibrin scaffold loaded TG2 gene-modified ectomesenchymal (TG2-EMSCs) derived from nasal respiratory mucosa Autocalcification cell-free gel osteogenic medium additional alkaline phosphatase (ALP) differentiation TG2-EMSCs on were...
Mesothelin (MSLN) is a glycoprotein with various expression degrees in different tumors including mesothelioma, ovarian cancer, pancreatic etc. MSLN considered to play an important role cell survival, proliferation, and tumor progression. Although the of makes it potential therapeutic target, its mechanism action still unclear, especially correlation immune cells infiltration microenvironment has not been investigated. In this study, we detected overexpression cancer using database analysis...
Cross-Priming Amplification (CPA) has been shown to rapidly and effectively detect Mycobacterium tuberculosis (MTB) in sputum samples under isothermal conditions. However, no performance data exist from peripheral-level (TB) clinics tuberculosis-endemic countries. We conducted a clinical trial at four county-level TB China evaluate the effectiveness of CPA assay. suspects were continuously enrolled by clinician each clinic. Following informed consent, patient provided two specimens (spot...