A5100328106- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Virus-based gene therapy research
- Advanced Memory and Neural Computing
- Cancer Research and Treatments
University of Pennsylvania
2025
Pennsylvania State University
2019-2021
Objective: Glioblastoma (GBM) is the most prevalent and aggressive adult primary cancer in central nervous system. Therapeuticapproaches for GBM treatment are under intense investigation, including use of emerging immunotherapies. Here, we proposean alternative approach to treat through reprogramming proliferative cells into non-proliferative neurons. Methods: Retroviruses were used target highly human overexpression neural transcriptionfactors. Immunostaining, electrophysiological...
Abstract Glioblastoma (GBM) is the most prevalent and aggressive adult primary cancer in central nervous system (CNS). Therapeutic approaches for glioblastoma are under intense investigation, such as emerging immunotherapy, but so far only marginal progress has been made due to heterogeneity highly invasive nature of glioblastoma. Here, we propose an alternative approach tackle GBM through reprogramming proliferative cells into non-proliferative neurons. We report efficient neuronal...
Abstract Background: Glioblastoma is one of the most severe primary cancer types in central nervous system. Because genomic and epigenetic heterogeneity, GBM infiltrative resistant to conventional treatments such as radiation, chemotherapy molecular targeting drugs. often arises from astrocytes, which can be directly converted into neurons according our earlier work, so we hypothesize that glioblastoma cells might also non-proliferating neurons. This trans-differentiation therapy provide a...