A5011973581- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Neonatal and fetal brain pathology
- Spinal Dysraphism and Malformations
- Head and Neck Surgical Oncology
- Spinal Fractures and Fixation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Pharmacological Effects and Toxicity Studies
- Neurological disorders and treatments
- Neuroblastoma Research and Treatments
- Innovations in Medical Education
- Genomics and Rare Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural dynamics and brain function
- Immune cells in cancer
- Meningioma and schwannoma management
- Fetal and Pediatric Neurological Disorders
- Neurosurgical Procedures and Complications
- EEG and Brain-Computer Interfaces
- Craniofacial Disorders and Treatments
- Spinal Cord Injury Research
- Surgical Simulation and Training
- Neuroscience and Neural Engineering
- Urban Agriculture and Sustainability
Children's Hospital of Philadelphia
2017-2025
University of Pennsylvania
2019-2025
Society for Invertebrate Pathology
2025
Neurological Surgery
2011-2024
Toronto Metropolitan University
2024
McGill University
2024
University of Pennsylvania Health System
2024
Columbia University Irving Medical Center
2010-2020
Anton Paar (United Kingdom)
2020
Philadelphia University
2019
Tumor-associated macrophages (TAMs) contribute substantially to the tumor mass of gliomas and have been shown play a major role in creation microenvironment that promotes progression. Shortcomings attempts at antiglioma immunotherapy may result from failure adequately address these effects. Emerging evidence supports an independent categorization glioma TAMs as alternatively activated M2-type macrophages, contrast classically proinflammatory M1-type macrophages. These exert glioma-supportive...
Convection-enhanced delivery of chemotherapeutics for the treatment malignant glioma is a technique that delivers drugs directly into tumor and surrounding interstitium through continuous, low-grade positive-pressure infusion. This allows high local concentrations drug while overcoming limitations imposed by toxicity blood-brain barrier in systemic therapies prevent use many potentially effective drugs.To examine safety profile conventional chemotherapeutic agent, topotecan, via...
Convection-enhanced delivery (CED) for the treatment of malignant gliomas is a technique that can deliver chemotherapeutic agents directly into tumor and surrounding interstitium through sustained, low-grade positive-pressure infusion. This allows high local concentrations drug within while minimizing systemic levels often lead to dose-limiting toxicity. Diffuse intrinsic pontine (DIPGs) are universally fatal childhood tumors which there currently no effective treatment. In this report...
OBJECT Symptomatic pediatric Chiari malformation Type I (CM-I) is most often treated with posterior fossa decompression (PFD), but controversy exists over whether the dura needs to be opened during PFD. While dural opening as a part of PFD has been suggested result in higher rate resolution CM symptoms, it also shown lead more frequent complications. In this paper, authors present largest reported series outcomes after without surgery, well identify risk factors for recurrence. METHODS The...
Craniopharyngioma represents up to 10% of pediatric brain tumors. Although these lesions are benign, attempts at gross-total resection (GTR) can lead serious complications. More conservative approaches have emerged but require adjuvant radiation. Endoscopic endonasal surgery (EES) aimed GTR has the potential result in fewer complications, there been limited comparison open surgery. The authors performed a review two within their institution elucidate benefits and complication differences.
Immunosuppression by gliomas contributes to tumor progression and treatment resistance. It is not known when immunosuppression occurs during development but it likely involves cross-talk among cells, tumor-associated macrophages microglia (TAMs), peripheral as well tumor-infiltrating lymphocytes (TILs).We have performed a kinetic study of this immunomodulation, assessing the dynamics immune infiltration function, within central nervous system (CNS) peripherally. PDGF-driven murine glioma...
Abstract Proneural glioblastoma is defined by an expression pattern resembling that of oligodendrocyte progenitor cells and carries a distinctive set genetic alterations. Whether there functional relationship between the proneural phenotype associated alterations unknown. To evaluate this possible relationship, we performed longitudinal molecular characterization tumor progression in mouse model glioma. In setting, tumors acquired remarkably consistent deletions at late stages progression,...
Work hours of physicians in training have been the subject debate for more than 4 decades. The profession sees them as emblematic dedication to patients, whose needs may not be confined a standard workday, whereas some members public view with concern safety patient care and well-being resident fellow physicians. In July 2003, Accreditation Council Graduate Medical Education (ACGME) established first set common work hour standards accredited residency fellowship programs,1 revision was...
The increasingly widespread use of stereo-EEG in the pre-surgical evaluation has led to greater recognition insula as both a source and surgical target for drug-resistant epilepsy. Clinicians have long appreciated challenges diagnosing treating seizures arising from insula. Insular-onset present with wide variety semiologies due its dense complex integration other brain structures, resulting insula's reputation "great mimicker." Surgical access is guarded by overlying frontal, temporal,...
Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity, learning and memory, but their evolutionary changes across species specialized features in humans remain poorly understood. Here we performed machine learning-augmented analysis of published single-cell RNA-sequencing datasets identified macaque imGCs with transcriptome-wide immature neuronal characteristics. Our cross-species comparisons among humans, monkeys, pigs, mice showed few...
INTRODUCTION: Minimally invasive procedures such as MRI-guided LiTT are increasingly being utilized in pediatric epilepsy patients; however, their clinical efficacy has been limited by challenges precisely localizing epileptogenic tissues. A precise and accurate means to highlight tissues noninvasively will augment the utility of LiTT. Previous studies have suggested that an apparent diffusion coefficient (ADC) map may microstructural abnormalities commonly seen temporal lobe provide a...
INTRODUCTION: Children with drug-resistant epilepsy (DRE) in whom resection or disconnective surgeries are not recommended can still benefit from neurostimulation. Vagus nerve stimulation is FDA-approved for ages = 4, but intracranial stimulators, responsive neurostimulation (RNS) and deep brain (DBS), only approved 18. Studies adults early experience children suggest that may be more effective than VNS, higher risk. This risk has been examined large cohorts. METHODS: retrospective study...
INTRODUCTION: Hemispherotomy represents definitive treatment for drug-resistant epilepsy with unilateral hemispheric onset. Traditional approaches involve a large incision and open craniotomy, associated risks of blood loss, infection, poor wound healing, pain, cosmetic concerns, long hospital stays. The authors describe minimally invasive technique performing hemispherotomy through single burr hole overlying the Sylvian fissure. METHODS: A retrospective analysis was performed on first seven...
ABSTRACT Background Hemispherectomy and hemispherotomy represent well‐established treatments for drug‐resistant hemispheric epilepsy. An alternative endovascular procedure has been explored cases with challenging surgical anatomy, which seeks to achieve the clinical effect of hemispherectomy via embolization major cerebral arteries subsequent infarction. Neither safety nor effectiveness this established. Patient Description A 4‐month‐old girl a history focal epilepsy due left‐sided...
BACKGROUND Focal epilepsy arising from the eloquent cortex can be treated with palliative surgical interventions such as multiple subpial transection (MST) or responsive neurostimulation (RNS). These techniques performed to reduce burden of disabling seizures while avoiding disability associated resection brain. OBSERVATIONS A 17-year-old girl a history complex, refractory multifocal and previous right anterior temporal lobectomy left neocortical RNS presented status epilepticus. Scalp...