A5037159536- Traumatic Brain Injury and Neurovascular Disturbances
- Medical and Biological Sciences
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Neurological Disorders and Treatments
- Management of metastatic bone disease
- Neurosurgical Procedures and Complications
- Healthcare Systems and Public Health
- History of Medical Practice
- Medical Imaging and Analysis
- Traumatic Brain Injury Research
- Anesthesia and Pain Management
- Glioma Diagnosis and Treatment
- S100 Proteins and Annexins
- Pelvic and Acetabular Injuries
- Mesenchymal stem cell research
- Musculoskeletal pain and rehabilitation
- Anesthesia and Neurotoxicity Research
- Neurogenesis and neuroplasticity mechanisms
- Cervical and Thoracic Myelopathy
- Meningioma and schwannoma management
- Long-Term Effects of COVID-19
- Medical History and Innovations
- Periodontal Regeneration and Treatments
- Genomics and Rare Diseases
Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine
2015-2025
National Academy of Medical Sciences of Ukraine
2015-2023
Лікування гліобластоми є актуальною проблемою нейроонкології, оскільки навіть сучасні медичні та технологічні розробки не дали змоги досягти значного прогресу в її вирішенні. Вальпроєва кислота протиепілептичним препаратом із доведеною ефективністю. Також вивчають потенційні онкостатичні ефекти при лікуванні пухлин головного мозку. Мета: вивчити вплив вальпроєвої кислоти на ріст гліоми C6 щурів in vivo. Матеріали і методи. Після експериментального моделювання проводили ін’єкції...
Background/Aim: Hypo-fractionated radiotherapy (HF-RT) is increasingly used for elderly and frail glioblastoma patients. In countries with limited capacities, HF-RT more widely applied. This allowed us to compare conventional fractionation (CF-RT) vs. in patients of any age performance status. Patients Methods: We retrospectively analysed 277 [110 (52.5 Gy 15 fractions) 167 CF-RT (54.0-60.0 27-33 fractions)] local control (LC) overall survival (OS) including subgroups considering specific...
to study the efficiency of gene therapy following traumatic brain injury (TBI) by evaluating influences liposomal transfection tissue APOE3-containing plasmid vector on structural and functional manifestations development secondary injuries after acute experimental TBI in rats different age.Severe diffuse was inflicted under overall anesthesia free load weighing 450 g, falling from a 1.5 m elevation. The mixture DOTAP liposome 25 μg pCMV·SPORT6 with cDNA APOE3 infused intraventricularly...
Glioblastoma (GBM) is the most aggressive primary malignant brain tumor in adults. The improvement of efficacy GBM treatment an urgent problem encouraging development novel therapeutic strategies, particular, immunotherapeutic modalities. With more understanding intimate interrelationships between immune system and mechanisms involved cancer origin progression, skepticism related to relevance approaches tumors gradually decreasing. review discloses modern concepts on association CNS system....
Mechanism of tumor progression in malignant gliomas and other tumors the body were studied to identify main pathogenetic link. Indicators charge cell membranes, including membranes blood cells, can be considered vein. These indicators are universal for any type tumors, not tissue-specific. many significant processes depend on level cellular charge, which emphasizes its dominant role. Interaction reparative inflamm
In 2016 in Ukraine 111 neurosurgery units with hospital bed capacity amounted to 3118 functioned. Over last 4 years (2013-2016) the level of hospitalization neurosurgical has increased by 7%, volume interventions rose 9%. Surgical activity 3.4%.Overall some reduction general and post-operative lethality is observed.Whereas SI Romodanov Neurosurgery Institute 11.6% (361 out 3118) total quantity patient performs two thirds all high-technology (endoscopic, endovascular, laser those using...
Stroke is a global medical and socio-economic problem great demand for alternative therapies, the leading one being stem cell (SC) therapy. Pathogenetic processes in ischemic stroke (II) trigger mechanisms of necrotic apoptotic death neurons with formation central infarct zone («core ischemia») «penumbra» zone; severity reversibility injury directly depends on duration ischemia. In parallel pathogenetic processes, endogenous neurogenesis occurs – proliferation neurogenic progenitor cells...
Objective. To analyse the dynamics, gender, age, and geographical peculiarities of cerebrovascular disease (CVD) mortality in Ukraine, to estimate indicator for coming years.Materials methods. A retrospective CVD study was conducted Ukraine. Mortality database (MDB) World Health Organization (WHO) data Ministry Ukraine (MoH) were used as starting material.Time series analysis regression analysis, hazard ratio (HR) used.Results. From 1991 2012, decreased by 7.2% (from 220.4 204.6 per 100,000...
Background. To date, no significant clinical progress has been achieved in the treatment of brain malignant gliomas (MG), and active search for non-invasive circulating biomarkers continues. The prognostic significance ratio main peripheral blood cell populations patients with MG is evaluated. Considerable attention paid to secretome platelets (Pt) blood. Aim. evaluate indicators population ratios study influence Pt (SPt) cultures vitro. Materials Methods. We studied samples from glioma CNS...
Background. Spinal diseases cause significant disability, with genetic factors influencing up to 70 % of cases. This study purposed examine the association polymorphisms COL1A1rs1800012, COL2A1rs2276454, COL2A1rs1793953 (collagen genes), and VDRrs2228570 L4-L5, L5-S1, C5-C7 intervertebral disc degeneration among ethnic Ukrainians. Materials methods. The included 90 individuals L5-S1 degeneration, 50 — L4-L5 30 C5-C7, 66 controls without degeneration. Applied Biosystems (USA) kits were used...
The object is to determine the state and performance indicators of bed density workforce neurosurgical network Ukraine. To conduct a comparative analysis data obtained with from other countries.Materials methods. work based on results continuous study density, workforce, medical departments Ukraine in 2014-2019. beds, their countries are taken scientific articles or open Internet sources.The did not include physicians located non-controlled territory. When calculating indicators, population...
Purpose. To study X-ray anatomy of craniovertebral zone considering structural features the second cervical vertebra for differential diagnosis pathology and its variable in clinical aspect.Materials methods. In period from 2004 to 2014 clinic 43 patients were examined, maldevelopments dens (CII) revealed. Clinical radiological examinations conducted, with functional tests, CT, MRI.Results. We used differentiated approach to: fixation CI–CII vertebrae; involving decompression on level...
Modern data of scientific literature on epidemiology, systems classification, early diagnostics and clinical features vestibular schwannoma (VS) were analyzed. Main attention was paid to VS diagnosis. The measures, aimed improve diagnosis given, that will treatment results minimize incidence postoperative complications disability patients with VS.
Any surgical intervention is associated with the possible development of complications. Surgical complications are traditionally an unpopular topic for discussion, but in recent decades they have received increased attention, due to both medical and economic factors. This review discusses general concepts that characterize negative consequences interventions spinal neurosurgery: complications, adverse events, sentinel never collateral outcomes. Classifications given allow systematizing these...
Objective. Evaluate the provision of neurosurgical care to patients with cerebrovascular diseases (CVD) in Ukraine and determine ways its improvement.Materials methods. The analysis has been performed based on statistical data regarding clinical departments neurosurgery within 2006-2015 years. methods sampling grouping series studies have used. Calculations using Microsoft Office Excel.Results. number CVD who were hospitalized into national increased by 76% (from 143 per 1 million population...
The issues of neurological complications after coronavirus disease 2019 (COVID-19) are highlighted, since coronaviruses affect not only the respiratory system but also other organs and systems body, notably they can cause disorders diseases. There is little evidence for a direct mechanism SARS-CoV-2 virus neuroinvasiveness neurotoxicity. Various mechanisms invasion into brain discussed - anterograde retrograde, neuronal spread, transcriptional hematogenous pathways. Retrograde / transport...
Objective: To study the possibility of improvement response to treatment injured persons with severe diffuse brain injury (SDBI) through intracranial pressure (ICP) monitoring and active correction hypertension (ICH) use decompressive craniectomy (DC).Material methods: A prospective analysis 57 SDBI was carried out. The first period research (2000 – 2005): 34 patients. second (2006 2012): 23 main criterion enrolment is a (8 points or less according GSC scale). L.F. Marshall classification...
The article is sanctified to the problem of standardization and objectification diagnosis development indicators quality surgical treatment patients with vestibular schwannomas (VS).Purpose. Objectification diagnostic criteria VS accordance international standards.Materials methods. Locations retro prospective analysis complex examination results 227 were in State institution Institute neurosurgery named after acad. A.P. Romodanov AMN Ukraine for period from 2005 present. In our series...
The purpose. To develop and provide into clinical practice the hi-tech method of autologous chondrocytes transplantation for treatment patients with intervertebral discs herniation after lumbar microdiscectomy.Material methods. were isolated from tissues disc hernia, cultivated preserved, administrated as percutaneous puncture in operated (3 months microdiscectomy).We plan to study influence transplanted on renewing height function (according methods, X-ray MRI).Results. In 6 was performed....
Introduction. Neurosurgical care, being highly specialized and highly-technological, is an indicator of state society development. As 01.01.2013 it was provided in 134 neurosurgical departments (in 2008 — 131) on 3,910 beds (2008 4,101) regional centers large cities Ukraine. Changes over 50 years show a significant quantitative qualitative improvement service Ukraine.Materials methods. Based analysis statistics data comparison indicators with National Health Service England, EANO Committee...