A5101943142- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Cytokine Signaling Pathways and Interactions
- Renal and related cancers
- CRISPR and Genetic Engineering
- Cancer Research and Treatments
- Genomic variations and chromosomal abnormalities
- Prenatal Screening and Diagnostics
- Molecular Biology Techniques and Applications
- Genomics and Phylogenetic Studies
- Genomics and Rare Diseases
- Reproductive Biology and Fertility
- Online Learning and Analytics
- Inflammatory Biomarkers in Disease Prognosis
- Fetal and Pediatric Neurological Disorders
- Radioactive element chemistry and processing
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- Regional Development and Environment
- Educational Reforms and Innovations
- Medical Research and Treatments
- Burn Injury Management and Outcomes
- Advanced Decision-Making Techniques
- Single-cell and spatial transcriptomics
University of California, San Diego
2020-2023
Huazhong University of Science and Technology
2023
Children’s Institute
2020-2022
Tongji University
2016-2022
People's Bank of China
2021
Institute of Economics
2020
Nanjing University of Finance and Economics
2014
Abstract High levels of IL1β can result in chronic inflammation, which turn promote tumor growth and metastasis. Inhibition could therefore be a promising therapeutic option the treatment cancer. Here, effects blockade induced by mAbs canakinumab gevokizumab were evaluated alone or combination with docetaxel, anti–programmed cell death protein 1 (anti–PD-1), anti-VEGFα, anti-TGFβ syngeneic humanized mouse models cancers different origin. Canakinumab did not show notable efficacy as...
De novo mutations underlie individually rare but collectively common pediatric congenital disorders. Some of these can also be detected in tissues and from cells a parent, where their abundance tissue distribution measured. We previously reported that subset is detectable sperm the father, predicted to impact health offspring.As cohort study, three independent couples undergoing vitro fertilization, we first identified male gonadal mosaicism through deep whole genome sequencing. then...
Abstract The structure of the human neocortex underlies species-specific features and is a reflection intricate developmental programs. Here we analyzed neocortical cellular lineages through comprehensive assessment brain somatic mosaicism—which acts as neutral recorder lineage history. We employed deep whole genome variant sequencing in single postmortem neurotypical across 25 anatomic regions three distinct modalities: bulk geographies, sorted cell types, nuclei. identified 259 mosaic...
In this study, we examined how supervisor developmental feedback influences employees’ innovative behavior. A multi-time survey method was used in study to collect data from 310 employees Chinese enterprises. The research results show that has positive effects on employee behavior via the mediating effect of self-goal-setting. We further found uncertainty avoidance strengthens relationship between and self-goal-setting employees. Our offers a new account based self-regulation perspective for...
Introductory paragraph Mosaic variants (MVs) reflect mutagenic processes during embryonic development 1 and environmental exposure 2 , accumulate with aging, underlie diseases such as cancer autism 3 . The detection of MVs has been computationally challenging due to sparse representation in non-clonally expanded tissues. While heuristic filters tools trained on clonally high allelic fractions are proposed, they show relatively lower sensitivity more false discoveries 4–9 Here we present...
The purpose of the research on bank resilience is to mobilize initiative banks in risk management. negative impact financial crisis was been regarded as an opportunity improve control ability banking industry's tolerance, self-healing and environmental adaptability market. This paper obtains theoretical significance through concept definition necessity analysis. Then, we analyze form process from dynamic static aspects, respectively, makes it clear that how valuable reform characteristic...
<div>Abstract<p>High levels of IL-1β can result in chronic inflammation, which turn promote tumor growth and metastasis. Inhibition could therefore be a promising therapeutic option the treatment cancer. Here, effects blockade induced by monoclonal antibodies canakinumab gevokizumab were evaluated alone or combination with docetaxel, anti-PD-1, anti-VEGFα anti-TGFβ syngeneic humanized mouse models cancers different origin. Canakinumab did not show notable efficacy as single-agent...
Summary Every newborn harbors scores of new single nucleotide variants (SNVs) that may impact health and disease 1–4 ; the majority these are contributed by paternal germ cells 5 . In some cases, mutations identifiable in a subset parents’ cells—a phenomenon called mosaicism, which is capable producing recurrence 6–8 Here, we provide comprehensive analysis male gonadal mosaic mutations, employing 300× whole genome sequencing (WGS) blood sperm 17 healthy individuals, including assessment...
Abstract Malformations of cortical development (MCD) are neurological conditions displaying focal disruption architecture and cellular organization arising during embryogenesis, largely from somatic mosaic mutations. Identifying the genetic causes MCD has been a challenge, as mutations remain at low allelic fractions in brain tissue resected to treat epilepsy. Here, we report atlas 317 resections, identifying 69 mutated genes through intensive profiling mutations, combining whole-exome...
<div>Abstract<p>High levels of IL-1β can result in chronic inflammation, which turn promote tumor growth and metastasis. Inhibition could therefore be a promising therapeutic option the treatment cancer. Here, effects blockade induced by monoclonal antibodies canakinumab gevokizumab were evaluated alone or combination with docetaxel, anti-PD-1, anti-VEGFα anti-TGFβ syngeneic humanized mouse models cancers different origin. Canakinumab did not show notable efficacy as single-agent...
<div>Abstract<p>High levels of IL1β can result in chronic inflammation, which turn promote tumor growth and metastasis. Inhibition could therefore be a promising therapeutic option the treatment cancer. Here, effects blockade induced by mAbs canakinumab gevokizumab were evaluated alone or combination with docetaxel, anti–programmed cell death protein 1 (anti–PD-1), anti-VEGFα, anti-TGFβ syngeneic humanized mouse models cancers different origin. Canakinumab did not show notable...
<div>Abstract<p>High levels of IL1β can result in chronic inflammation, which turn promote tumor growth and metastasis. Inhibition could therefore be a promising therapeutic option the treatment cancer. Here, effects blockade induced by mAbs canakinumab gevokizumab were evaluated alone or combination with docetaxel, anti–programmed cell death protein 1 (anti–PD-1), anti-VEGFα, anti-TGFβ syngeneic humanized mouse models cancers different origin. Canakinumab did not show notable...
To explore the effects of resistance training with elastic band at home on muscle function and walking ability severely burned children.