A5001065861- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Ion channel regulation and function
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neurological disorders and treatments
- Organometallic Complex Synthesis and Catalysis
- Neuroscience and Neural Engineering
- Crystallography and molecular interactions
- Neuropeptides and Animal Physiology
- Nicotinic Acetylcholine Receptors Study
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Cannabis and Cannabinoid Research
- Catalytic Cross-Coupling Reactions
- Pain Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Synthesis and characterization of novel inorganic/organometallic compounds
- Anesthesia and Neurotoxicity Research
- Magnetism in coordination complexes
- Polyoxometalates: Synthesis and Applications
- Treatment of Major Depression
Karlsruhe Institute of Technology
2013-2023
University of Freiburg
2011-2023
Karlsruhe University of Education
2017-2020
Independent Dance
2020
Kantonsspital Winterthur
2018
University Medical Center Freiburg
2003-2017
Medical University of Vienna
1987-2011
Klinik und Poliklinik für Neurologie
1988-2008
Euro-Centrum
2003
Heinrich Heine University Düsseldorf
2003
Summary: A multicenter, double‐blind, randomized, placebo‐controlled study evaluated the efficacy and safety of gabapentin (Neurontin, GBP) as add‐on therapy in 272 patients with refractory partial seizures who were receiving one to two standard antiepileptic drugs (AEDs). Efficacy assessments compared frequency during 12‐week treatment phase (T) baseline period (B). The primary analysis data for GBP 900 mg/day placebo; 1,200‐mglday group provided doseresponse data. criteria percentage...
Members of the cytochrome P450 (P450) family drug-metabolizing enzymes are present in human brain, and they may have important roles oxidation endogenous substrates. The polymorphic CYP2D6 is one major brain isoforms has been implicated neurodegeneration, psychosis, schizophrenia, personality traits. objective this study was to determine whether endocannabinoid arachidonoylethanolamide (anandamide) a substrate for CYP2D6. Anandamide ligand cannabinoid receptor CB1, which also activated by...
In contrast to the abundance of seizure outcome reports in epilepsy surgery for glioneuronal tumors childhood and adolescence, there is a dearth information regarding cognitive outcomes.To investigate children adolescents that underwent resective tumor-associated refractory determine their predictive factors.We retrospectively analyzed presurgical findings, resection types, outcomes over 1.3 12.3 years (mean, 7.3) 29 consecutive patients, who 2000 2011. The mean age at onset was 7.9 (range,...
Summary: Purpose: Gabapentin (GBP) is a commonly used drug in the treatment of partial seizures, but its mode action still unclear. The genesis seizures temporal lobe epilepsy thought to be crucially influenced by intrinsic membrane properties. Because I h substantially contributes properties neurons, effects GBP on were investigated CA1 pyramidal cells rat hippocampus. Methods: hippocampal slices examined using whole‐cell patch‐clamp technique. Results: increased amplitude...
Abstract The hyperpolarization‐activated current ( I h ) contributes to intrinsic properties and network responses of neurons. Its biophysical depend on the expression profiles underlying hyperpolarization‐activated, cyclic nucleotide‐gated (HCN) channels presence AMP (cAMP) that potently differentially modulates conducted by HCN1, HCN2 and/or HCN4. Here, we studied in hippocampal CA1 pyramidal cells, developmental evolution HCN‐subunit isoforms contribute this current, their interplay with...
As one of the best studied photoswitches, spiropyrans (SPs) have attracted significant interest in scientific community. Among many stimuli to alter isomerization into merocyanine (MC) isomer, such as temperature, pH, solvent polarity, redox potential, or mechanical force, ability MC form act a ligand site for metal complexation has recently raised new attention. We herein synthesize hitherto undescribed coordination compounds...
Summary: Purpose: To report on the occurrence of myoclonus in patients receiving pregabalin (PGB) for treatment focal epilepsy. Methods: Clinic records 19 who were consecutively enrolled at a tertial referral epilepsy center randomized, double‐blind and/or open add‐on study with PGB reviewed. Results: In four treated PGB, newly developed. The side effect appeared doses 50–600 mg/day; intensity showed some dose dependency. All had medically refractory and received other antiepileptic drugs...
Slices of the rabbit caudate nucleus were incubated with [3H]choline or [3H]dopamine and then superfused continuously Mg(++)-free medium. Stimulation N-methyl-D-aspartate (NMDA), alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA), L-glutamate kainic (in that rank order potencies) caused a concentration-dependent increase in [3H]ACh efflux, which was abolished presence Mg++. This kind release Ca(++)-dependent tetrodotoxin-sensitive. In contrast, NMDA hardly effective...
The positively charged and weakly polarizable s-block metals commonly do not usually have phosphine ligands in molecular complexes. Herein, we report mono- dinuclear small diamidophosphine complexes of the alkaline-earth Mg, Ca, Sr, which were prepared from simple precursors a phosphine-functionalized diamine ligand N,N-bis(2-(diphenyl-phosphino)phenyl)ethane-1,2-diamine (PNHNHP). metal based [(PNNP)Mg]2 [(PNNP)M(thf)3 ] (M=Ca, Sr), exhibit unusual coordination spheres show bright...
The main purpose of the present study was to investigate effects neuroprotective agent riluzole on electrically evoked release [ 3 H]‐glutamate ([ H]‐Glu) in mouse neocortical slices. reported selectivity for excitatory amino acids tested experiments with further neurotransmitters. Also distinct species, mouse, rat and man were compared. H]‐Glu formed endogenously during incubation slices H]‐glutamine H]‐Gln). Released tissue separated by anion exchange chromatography. Electrically strongly...
Abstract The contribution of the hyperpolarization‐activated cation current (I h ) to input resistance (R N and resting potential (RP) was investigated during whole‐cell patch‐clamp recordings in CA1 pyramidal cells rat hippocampal slices. In current‐clamp mode, R determined at different membrane potentials. decreased with increasing hyperpolarization, from about 260 MΩ 140 potentials −60 mV −110 mV, respectively. Both half‐maximal reduction I activation (determined voltage‐clamp mode) were...
In the presence of silver(I) fluoride, highly fluorinated olefins react readily under solvent-free conditions with arenes via CH-substitution. This transformation could be used to synthesize various methoxycarbonyltetrafluoroethylated aromatic triazenes and anisoles high functional group tolerance. The method applied synthesis a formal bioisostere NSAID flurbiprofen. To best our knowledge, this is first example which uses for perfluoroalkylation substrates.