A5001041177- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Genetics and Neurodevelopmental Disorders
- Neurological disorders and treatments
- Neurobiology of Language and Bilingualism
- Neonatal and fetal brain pathology
- Psychosomatic Disorders and Their Treatments
- Diet and metabolism studies
- Tuberous Sclerosis Complex Research
- Cannabis and Cannabinoid Research
- Memory and Neural Mechanisms
- Genomics and Rare Diseases
- Neuroscience and Neural Engineering
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Sleep and Wakefulness Research
- Metabolism and Genetic Disorders
- Neuroscience of respiration and sleep
- Genomic variations and chromosomal abnormalities
- Neuroscience and Music Perception
- Cardiac electrophysiology and arrhythmias
New York University
2016-2025
NYU Langone Health
2016-2025
University School
2016-2025
Hinge Health
2023-2025
Neurology, Inc
2011-2024
New York Proton Center
1985-2024
Toronto Western Hospital
2023-2024
University Health Network
2023-2024
Epilepsy Foundation
2007-2024
University of Toronto
2020-2024
The Dravet syndrome is a complex childhood epilepsy disorder that associated with drug-resistant seizures and high mortality rate. We studied cannabidiol for the treatment of in syndrome.In this double-blind, placebo-controlled trial, we randomly assigned 120 children young adults to receive either oral solution at dose 20 mg per kilogram body weight day or placebo, addition standard antiepileptic treatment. primary end point was change convulsive-seizure frequency over 14-week period, as...
Cannabidiol has been used for treatment-resistant seizures in patients with severe early-onset epilepsy. We investigated the efficacy and safety of cannabidiol added to a regimen conventional antiepileptic medication treat drop Lennox–Gastaut syndrome, developmental epileptic encephalopathy.
Summary: Purpose: We report the development of a questionnaire to assess health‐related quality of‐life (HRQOL) in people with epilepsy and process cross‐cultural translations questionnaire. Methods: A sample 304 adults from 25 seizure clinics United States was used derive an abbreviated focusing on epilepsy‐related issues longer, 89‐item instrument (QOLIE‐89). rigorous forward‐backward‐forward system for translation. Results: 31‐item (QOLIE‐31, version 1.0) resulted, comprising seven...
<b><i>Background:</i></b> The two-thirds of patients with epilepsy who become seizure-free have a quality life (QOL) similar to the general population. major treatment challenge is refractory epilepsy. Whereas neurologists typically focus on seizure reduction in these patients, results studies relating frequency QOL are conflicting. As depression associated reduced and antiepileptic medications (AEDs) can cause depression, it important determine relative roles <b><i>Methods:</i></b>...
Summary: We developed an instrument to measure health‐related quality of life (HRQOL) in epilepsy. A 99‐item inventory was constructed from the RAND 36‐Item Health Survey (generic core), with 9 additional generic items, 48 epilepsy‐targeted and 6 other items concerning attitudes toward epilepsy self‐esteem. administered 304 adults at 25 centers. Patients patient‐designated proxies completed were retested 1–91 days later. multitrait scaling analysis these data led retention 86 distributed 17...
Transcranial electric stimulation aims to stimulate the brain by applying weak electrical currents at scalp. However, magnitude and spatial distribution of fields in human are unknown. We measured potentials intracranially ten epilepsy patients estimated across entire leveraging calibrated current-flow models. When stimulating 2 mA, cortical reach 0.8 V/m, lower limit effectiveness animal studies. individual whole-head anatomy is considered, predicted field magnitudes correlate with recorded...
Progressive functional decline in the epilepsies is largely unexplained. We formed ENIGMA-Epilepsy consortium to understand factors that influence brain measures epilepsy, pooling data from 24 research centres 14 countries across Europe, North and South America, Asia, Australia. Structural were extracted MRI scans 2149 individuals with divided into four epilepsy subgroups including idiopathic generalized (n =367), mesial temporal lobe hippocampal sclerosis (MTLE; left, n = 415; right, 339),...
The epilepsies affect around 65 million people worldwide and have a substantial missing heritability component. We report genome-wide mega-analysis involving 15,212 individuals with epilepsy 29,677 controls, which reveals 16 significant loci, of 11 are novel. Using various prioritization criteria, we pinpoint the 21 most likely genes at these majority in genetic generalized epilepsies. These diverse biological functions, including coding for ion-channel subunits, transcription factors...
Eighteen patients with medically intractable Parkinson's disease that was characterized by bradykinesia, rigidity, and marked "on-off" fluctuations underwent stereotactic ventral pallidotomy under local anesthesia. Targeting aided anatomic coordinates derived from the MRI, intraoperative cell recordings, electrical stimulation prior to lesioning. A nonsurgically treated group of seven similarly affected individuals also followed. Assessment motor function made at baseline 3-month intervals...
<h3>Objective</h3> To evaluate the safety and preliminary pharmacokinetics of a pharmaceutical formulation purified cannabidiol (CBD) in children with Dravet syndrome. <h3>Methods</h3> Patients aged 4–10 years were randomized 4:1 to CBD (5, 10, or 20 mg/kg/d) placebo taken twice daily. The double-blind trial comprised 4-week baseline, 3-week treatment (including titration), 10-day taper, follow-up periods. Completers could continue an open-label extension. Multiple pharmacokinetic blood...
The electroencephalogram (EEG) is a mainstay of clinical neurology and tightly correlated with brain function, but the specific currents generating human EEG elements remain poorly specified because lack microphysiological recordings. largest event in healthy EEGs K-complex (KC), which occurs slow-wave sleep. Here, we show that KCs are generated widespread cortical areas by outward dendritic middle upper layers, accompanied decreased broadband power neuronal firing, demonstrate steep decline...
The alpha rhythm is the longest-studied brain oscillation and has been theorized to play a key role in cognition. Still, its physiology poorly understood. In this study, we used microelectrodes macroelectrodes surgical epilepsy patients measure intracortical thalamic generators of during quiet wakefulness. We first found that both visual somatosensory cortex propagates from higher-order lower-order areas. posterior cortex, anterosuperior areas toward occipital pole, whereas associative...