A5038885649- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Pharmaceutical studies and practices
- Pregnancy and Medication Impact
- Drug Transport and Resistance Mechanisms
- EEG and Brain-Computer Interfaces
- Neonatal and fetal brain pathology
- Metabolism and Genetic Disorders
- Genetics and Neurodevelopmental Disorders
- Genomics and Rare Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Ion channel regulation and function
- Anesthesia and Sedative Agents
- Diet and metabolism studies
- Neurological and metabolic disorders
- Psychosomatic Disorders and Their Treatments
- Functional Brain Connectivity Studies
- Statistical Methods in Clinical Trials
- Hemoglobinopathies and Related Disorders
- Tuberous Sclerosis Complex Research
- Computational Drug Discovery Methods
- Meta-analysis and systematic reviews
- Glioma Diagnosis and Treatment
New York University
2016-2025
NYU Langone Health
2016-2025
Epilepsy Foundation
2015-2025
Comprehensive Clinical Research
2015-2025
Epilepsy Foundation
2014-2025
University of Michigan
2024
University of Pittsburgh
2014-2024
University of California, Los Angeles
2024
Columbia University
2007-2024
Vanderbilt University Medical Center
2004-2024
The International League Against Epilepsy (ILAE) Commission on Classification and Terminology has revised concepts, terminology, approaches for classifying seizures forms of epilepsy. Generalized focal are redefined as occurring in rapidly engaging bilaterally distributed networks (generalized) within limited to one hemisphere either discretely localized or more widely (focal). generalized is simplified. No natural classification exists; should be described according their manifestations...
The International League Against Epilepsy (ILAE) Classification of the Epilepsies has been updated to reflect our gain in understanding epilepsies and their underlying mechanisms following major scientific advances that have taken place since last ratified classification 1989. As a critical tool for practicing clinician, epilepsy must be relevant dynamic changes thinking, yet robust translatable all areas globe. Its primary purpose is diagnosis patients, but it also research, development...
Summary To improve patient care and facilitate clinical research, the International League Against Epilepsy (ILAE) appointed a Task Force to formulate consensus definition of drug resistant epilepsy. The overall framework has two “hierarchical” levels: Level 1 provides general scheme categorize response each therapeutic intervention, including minimum dataset knowledge about intervention that would be needed; 2 core epilepsy using set essential criteria based on categorization (from 1)...
The International League Against Epilepsy (ILAE) presents a revised operational classification of seizure types. purpose such revision is to recognize that some types can have either focal or generalized onset, allow when the onset unobserved, include missing types, and adopt more transparent names. Because current knowledge insufficient form scientifically based classification, 2017 Classification (practical) on 1981 Classification, extended in 2010. Changes following: (1) "partial" becomes...
We report a multicenter, double-blind, randomized trial of bilateral stimulation the anterior nuclei thalamus for localization-related epilepsy.Participants were adults with medically refractory partial seizures, including secondarily generalized seizures. Half received and half no during 3-month blinded phase; then all unblinded stimulation.One hundred ten participants randomized. Baseline monthly median seizure frequency was 19.5. In last month phase stimulated group had 29% greater...
We have created early-onset transgenic (Tg) models by exploiting the synergistic effects of familial Alzheimer's disease mutations on amyloid β-peptide (Aβ) biogenesis. TgCRND8 mice encode a double mutant form precursor protein 695 (KM670/671NL+V717F) under control PrP gene promoter. Thioflavine S-positive Aβ deposits are present at 3 months, with dense-cored plaques and neuritic pathology evident from 5 months age. exhibit 3,200–4,600 pmol Aβ42 per g brain age 6 an excess over Aβ40. High...
Summary This companion paper to the introduction of International League Against Epilepsy ( ILAE ) 2017 classification seizure types provides guidance on how employ classification. Illustration is enacted by tables, a glossary relevant terms, mapping old new suggested abbreviations, and examples. Basic extended versions are available, depending desired degree detail. Key signs symptoms seizures (semiology) used as basis for categories that focal or generalized from onset with unknown onset....
Abstract In order to more precisely define a syndrome of medial temporal lobe epilepsy, histories and physical findings were evaluated in 67 patients studied with intracranial electrodes who had seizure onset became free following lobectomy. Patients circumscribed, potentially epileptogenic mass lesions excluded. Fifty‐four (81%) convulsions during early childhood or infancy, 52 which associated fever. Complicated febrile seizures occurred 33 (94%) the 35 whom detailed descriptions...
To report long-term efficacy and safety results of the SANTE trial investigating deep brain stimulation anterior nucleus thalamus (ANT) for treatment localization-related epilepsy.This follow-up is a continuation previously reported 5- vs 0-V ANT stimulation. Long-term began 13 months after device implantation with parameters adjusted at investigators' discretion. Seizure frequency was determined using daily seizure diaries.The median percent reduction from baseline 1 year 41%, 69% 5 years....
Everolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been used for various benign tumours associated with tuberous sclerosis complex. We assessed the efficacy and safety two trough exposure concentrations everolimus, 3-7 ng/mL (low exposure) 9-15 (high exposure), compared placebo as adjunctive therapy treatment-resistant focal-onset seizures in complex.In this phase 3, randomised, double-blind, placebo-controlled study, eligible patients aged 2-65 years complex (≥16 an 8-week...
Animal studies and sporadic case reports in human subjects have suggested that intermittent electrical stimulation of the anterior nucleus thalamus reduces seizure activity. We embarked on an open-label pilot study to determine initial safety tolerability bilateral (ANT), a range appropriate parameters, begin gather efficacy data.We report five patients (three men, two women; age range, 24-47 years), with follow-up between 6 36 months. All had intractable partial epilepsy. Four also...
To determine the incidence rates of sudden unexpected death in epilepsy (SUDEP) different populations and address question whether risk factors for SUDEP have been identified.Systematic review evidence; modified Grading Recommendations Assessment, Development, Evaluation process developing conclusions; recommendations developed by consensus.Findings based on 12 Class I studies include following: children with (aged 0-17 years) is 0.22/1,000 patient-years (95% confidence interval [CI]...
<h3>Objective:</h3> To assess efficacy and safety of once-daily 8 or 12 mg perampanel, a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, when added to concomitant antiepileptic drugs (AEDs) in the treatment drug-resistant partial-onset seizures. <h3>Methods:</h3> This was multicenter, double-blind, placebo-controlled trial (ClinicalTrials.gov identifier: NCT00699972). Patients (≥12 years, with ongoing seizures despite 1–3 AEDs) were randomized...
Abstract Sixty‐seven patients with temporal lobe epilepsy without circumscribed, potentially epileptogenic lesions, who were studied intracranial electrodes and became seizure free following lobectomy retrospectively evaluated regard to preoperative scalp electroencephalographic (EEG) findings, neuropsychological test results, neuroimaging results of surgery, pathology resected tissue. Interictal EEG showed paroxysmal abnormalities during prolonged monitoring in 64 (96%). These localized the...
There is not yet a clear consensus on the incidence of sudden unexpected death in epilepsy (SUDEP) or extent its burden public health. In this systematic review, we seek to summarize SUDEP and age distribution, as well years potential life lost cumulative risks for persons with epilepsy.We conducted search epidemiologic studies rated their quality evidence. We pooled data from comparable higher population-based across all groups, calculating overall per 100,000 population, 1,000 people...