A5077690362- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Electoral Systems and Political Participation
- Pharmaceutical studies and practices
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Political Influence and Corporate Strategies
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Social Media and Politics
- Gender Politics and Representation
- Electroconvulsive Therapy Studies
- Neonatal and fetal brain pathology
- Neural dynamics and brain function
- Drug Transport and Resistance Mechanisms
- Infectious Encephalopathies and Encephalitis
- Treatment of Major Depression
- Medical Image Segmentation Techniques
- Advanced Neuroimaging Techniques and Applications
- Respiratory and Cough-Related Research
- Visual perception and processing mechanisms
- Olfactory and Sensory Function Studies
- Metabolism and Genetic Disorders
- Glaucoma and retinal disorders
Washington University in St. Louis
2016-2025
Royal College of Surgeons in Ireland
2023
Neurology, Inc
2023
Montreal Neurological Institute and Hospital
2021-2022
McGill University
2021-2022
Fondazione IRCCS Istituto Neurologico Carlo Besta
2022
Meyer Children's Hospital
2022
University of Florence
2022
The University of Melbourne
2022
Centre National de la Recherche Scientifique
2022
<h3>Objective:</h3> To assess efficacy and safety of once-daily 8 or 12 mg perampanel, a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, when added to concomitant antiepileptic drugs (AEDs) in the treatment drug-resistant partial-onset seizures. <h3>Methods:</h3> This was multicenter, double-blind, placebo-controlled trial (ClinicalTrials.gov identifier: NCT00699972). Patients (≥12 years, with ongoing seizures despite 1–3 AEDs) were randomized...
Summary Purpose Posttraumatic epilepsy ( PTE ) occurs in a proportion of traumatic brain injury TBI cases, significantly compounding the disability, and risk death for sufferers. To date, predictive biomarkers have not been identified. This study used lateral fluid percussion LFPI rat model to investigate whether structural, functional, behavioral changes post‐ relate later development . Methods Adult male W istar rats underwent or sham injury. Serial magnetic resonance MR positron emission...
How epilepsy affects brain functional networks remains poorly understood. Here we investigated resting state connectivity of the temporal region in lobe epilepsy. Thirty-two patients with unilateral underwent blood-oxygenation level dependent magnetic resonance imaging. We defined regions interest a priori focusing on structures involved, either structurally or metabolically, These were identified each patient based their individual anatomy. Our principal findings are decreased local and...
Multiple sclerosis (MS) is the most common demyelinating and an autoimmune disease of central nervous system characterized by immune-mediated myelin axonal damage, chronic loss attributable to absence sheaths. T cell subsets (Th1, Th2, Th17, CD8+, NKT, CD4+CD25+ regulatory cells) B cells are involved in this disorder, thus new MS therapies seek damage prevention resetting multiple components immune system. The currently approved immunoregulatory reduce number rate lesion formation but only...
To test the hypothesis that a multicenter-validated computer deep learning algorithm detects MRI-negative focal cortical dysplasia (FCD).We used clinically acquired 3-dimensional (3D) T1-weighted and 3D fluid-attenuated inversion recovery MRI of 148 patients (median age 23 years [range 2-55 years]; 47% female) with histologically verified FCD at 9 centers to train convolutional neural network (CNN) classifier. Images were initially deemed in 51% patients, whom intracranial EEG determined...
A Phase 3 open-label safety study (NCT02721069) evaluated long-term of diazepam nasal spray (Valtoco) in patients with epilepsy and frequent seizure clusters.Patients were 6-65 years old diagnosed clusters despite stable antiseizure medications. The treatment period was 12 months, visits at Day 30 every 60 days thereafter, after which could elect to continue. Doses based on age weight. Seizure information recorded diaries. Treatment-emergent adverse events (TEAEs), irritation, olfactory...
Since its introduction to neurosurgery in 2008, laser ablative techniques have been largely confined the management of unresectable tumors. Application this technology for focal epilepsy adult population has not fully explored. Given that nearly 1,000,000 Americans live with medically refractory and current surgical only address a fraction epileptic pathologies, additional therapeutic options are needed. We report successful treatment dominant insular 53-year-old male minimally invasive...
Abstract Objective The study assesses the bioavailability of diazepam after intranasal administration (diazepam nasal spray) in healthy volunteers. Comparative agents were rectal gel, which served as regulatory reference product; and oral diazepam, a product with decades clinical use. Tolerability spray was also assessed. Methods This phase 1, open‐label, randomized, single‐dose, three‐treatment, three‐period, six‐sequence crossover 48 adult subjects that consisted screening period, baseline...
Ideal rescue treatments for acute treatment of seizure clusters should be easy to administer, so it is important assess user perceptions these treatments. Diazepam nasal spray designed have a rapid, noninvasive, and socially acceptable route administration. Patient caregiver (including care partner) responses surveys from phase 3 safety study diazepam are reported.The enrolled patients aged 6-65 years with clusters. Surveys distributed caregivers at end, completion, or discontinuation...
In five patients with mesial temporal sclerosis, the authors verified precision and reproducibility of hippocampal segmentations deformation-based magnetic resonance (MR) imaging. The overall percentage overlap between automated was 92.8% (SD, 3.5%), manual 73.1% 9.5%), 74.8% 10.3%). Deformation-based provided a precise method volume measurement in this patient population.
This article examines the influence of campaign election laws on patterns candidacy in state legislative elections. Previous studies demonstrate that restrictions contributions affect levels spending and competition, but do such legal conditions likelihood incumbents running for reelection are even challenged? How important is this effect relative to other factors, as ballot access district political variables, influencing rates contestation primary general elections? Analyses state-...
Traumatic brain injury (TBI) has a high incidence of long-term neurologic and neuropsychiatric morbidity. Metabolic structural changes in rat brains were assessed after TBI using serial <sup>18</sup>F-FDG PET 3-dimensional MRI vivo. <b>Methods:</b> Rats underwent lateral fluid percussion (FPI; <i>n</i> = 16) or sham procedure (<i>n</i> 11). MR images acquired at 1 wk 1, 3, 6 mo injury. Morphologic MRI-based regions interest, hippocampal shape with large-deformation high-dimensional mapping....
Abstract Objective To assess pharmacokinetics and safety of diazepam nasal spray (NRL‐1; VALTOCO®) in pediatric adult patients with epilepsy seizure nonseizure states. Methods A single dose (5, 10, 15, or 20 mg based on weight) was administered during each two conditions (ictal/peri‐ictal interictal condition) to 6‐65 years old partial generalized motor seizures clear alteration awareness; a second permitted if needed for persistent seizures. Dosing could be ictal/peri‐ictal first, washout...
The Role of SPECT and PET in EpilepsyMaria R. Ponisio, MD1, John M. Zempel, MD2, Brian K. Day, Lawrence N. Eisenman, Michelle Miller-Thomas, Matthew D. Smyth, MD3 Edward Hogan, MD2Audio Available | Share
Sex differences in drug pharmacokinetics include variations the expression of cytochrome P450 enzymes, which are involved metabolism benzodiazepines. It is unclear whether sex influences outcomes associated with intranasally administered drugs. A post hoc analysis was conducted to evaluate effectiveness and safety diazepam nasal spray, included examining changes number days between seizure clusters over time (SEIzure interVAL [SEIVAL]). Diazepam spray approved for acute treatment patients...
Electroconvulsive therapy (ECT) is a highly effective treatment for refractory depression, but it may also cause cognitive side effects. Despite decades of use, the mechanisms by which ECT exerts both its antidepressant and effects are still poorly understood, with latter substantially limiting referral adherence to therapy. induces changes in correlated neural activity-functional connectivity-across various brain networks, underlie clinical efficacy associated Electroencephalography (EEG)...
The fourteen insightful essays in this timely volume focus on the different ways which ethnic American writers use memory as a device to redefine history and culture, validate both personal collective identity, shape narrative. contributors articulate how works of diverse African, Mexican, Irish, Chinese, South Asian, Jewish, Native descent chart memory's forays into language, narrative, identity. cultural political realities race ethnicity life - refracted through imagination give special...
Does policy responsiveness on the part of incumbent legislators affect their prospects for reelection? Recent studies congressional campaigns demonstrate that incumbents who support policies are more congruent with constituents' preferences face fewer reelection obstacles. The present analysis considers this question in state legislative elections where voter knowledge legislator activities is generally quite low. findings positioned farther from average citizen and toward party's base only...