A5082747430- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neonatal and fetal brain pathology
- Peripheral Neuropathies and Disorders
- Neuroscience and Neuropharmacology Research
- Hereditary Neurological Disorders
- EEG and Brain-Computer Interfaces
- Ion channel regulation and function
- Glycogen Storage Diseases and Myoclonus
- Genetics and Neurodevelopmental Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Anesthesia and Neurotoxicity Research
- Fetal and Pediatric Neurological Disorders
- Trigeminal Neuralgia and Treatments
- Hematological disorders and diagnostics
- Nerve injury and regeneration
- Dermatological and COVID-19 studies
- Advanced Neuroimaging Techniques and Applications
- Sarcoidosis and Beryllium Toxicity Research
- Neurological disorders and treatments
- Ion Transport and Channel Regulation
- Metabolism and Genetic Disorders
- Mosquito-borne diseases and control
- Neurogenetic and Muscular Disorders Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Garrahan Hospital
1994-2023
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
1998-2023
University of Carabobo
2018
Hospices Civils de Lyon
2018
Hôpital Femme Mère Enfant
2018
<h3>Objective:</h3> To assess efficacy and safety of once-daily 8 or 12 mg perampanel, a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, when added to concomitant antiepileptic drugs (AEDs) in the treatment drug-resistant partial-onset seizures. <h3>Methods:</h3> This was multicenter, double-blind, placebo-controlled trial (ClinicalTrials.gov identifier: NCT00699972). Patients (≥12 years, with ongoing seizures despite 1–3 AEDs) were randomized...
Abstract Objective To develop and validate a model to predict seizure freedom in children undergoing cerebral hemispheric surgery for the treatment of drug‐resistant epilepsy. Methods We analyzed 1267 surgeries performed pediatric participants across 32 centers 12 countries identify predictors at 3 months after surgery. A multivariate logistic regression was developed based on 70% dataset (training set) validated 30% (validation set). Missing data were handled using multiple imputation...
This study was undertaken to determine whether the vertical parasagittal approach or lateral peri-insular/peri-Sylvian hemispheric surgery is superior technique in achieving long-term seizure freedom. We conducted a post hoc subgroup analysis of HOPS (Hemispheric Surgery Outcome Prediction Scale) study, an international, multicenter, retrospective cohort that identified predictors freedom through logistic regression modeling. Only patients undergoing parasagittal, peri-insular/peri-Sylvian,...
Although hemispheric surgeries are among the most effective procedures for drug-resistant epilepsy (DRE) in pediatric population, there is a large variability seizure outcomes at group level. A recently developed HOPS score provides individualized estimation of likelihood freedom to complement clinical judgement. The objective this study was develop freely accessible online calculator that accurately predicts probability any patient 1-, 2-, and 5-years post-hemispherectomy. Retrospective...
The aim of this study was to determine the causes fever unknown origin, evaluate new diagnostic tests and elucidate risk factors for chronic or life-threatening disorders. medical records 113 children who had undiagnosed at least 3 weeks were reviewed. Infection (N = 41) most frequent cause origin. Respiratory tract infections common in infants endocarditis tuberculosis more older children. Neoplastic disorders 11) occurred than one year. Juvenile rheumatoid arthritis 9) collagen-vascular...
Spasms are defined as epileptic seizures characterized by brief axial contraction, in flexion, extension or mixed, symmetric asymmetric, lasting from a fraction of second to 1-2s, and associated with slow-wave transient sharp complex, followed not voltage attenuation. Epileptic spasms usually appear clusters age-dependent. This type the particular EEG pattern, hypsar rhythmia, constitutes basis for diagnosis West syndrome. The question is, how nosologically define those patients who clearly...
ABSTRACT Aim . The aim of this study was to analyse the electroclinical and imaging findings outcome patients with Rasmussen syndrome (RS) atypical manifestations. Methods We conducted a retrospective, descriptive 10 44 consecutive RS features, followed between 1999 2017. Results Six were boys four girls. mean median ages at onset seizures 8.8 6.5 years, respectively (range: 4.6‐13 years). All except one had seizures. Eight (80%) epilepsia partialis continua that started age 7.5 years 7–15...
Objective We evaluated the electroclinical features, etiology, treatment, and outcome of 16 patients with single-epileptic spasms (ESs) or without hypsarrhythmia (WoH). Methods Nine boys seven girls had single-ESs. ESs were considered as single epileptic spasm variants when no other occurred for 1 minute before after each spasm. Age at onset was between 2 84 months, a mean age 11 months. Results recognized group 15 single-ESs main type seizure; 6 WoH 9 hypsarrhythmia, respectively. these...
Background: A subset of pediatric epilepsy patients suffer from syndromes related to multi-lobar or hemispheric epileptogenic networks and diseases. Most these are refractory anti-seizure drug treatment, resulting in persistent disabling seizures, neurocognitive delay impaired quality life. In well-selected patients, surgery is associated with excellent seizure freedom rates relatively low complication rates. Nevertheless, 30% develop recurrence after cerebral surgery. The purpose this study...
Objetivo: Evaluar los resultados del tratamiento quirúrgico en un grupo de pacientes con epilepsia refractaria asociada a malformaciones desarrollo cortical (MDC). Pacientes y método: Realizamos estudio retrospectivo una serie 160 pacientes, seleccionados total 581 (27,5%), operados por algún tipo malformación (MDC), desde enero 1988 hasta abril 2010, el Hospital Nacional Pediatría “Juan P Garrahan”, Instituto FLENI, Niños “R. Gutiérrez” “Cosme Argerich”, todos Buenos Aires, Argentina. Los...
El abordaje quirúrgico de las epilepsias que asientan en áreas elocuentes, especial comprometían al área central, se remontan siglo XIX. Las primeras cirugías esta son llevadas a cabo por los neurocirujanos Macewen y Horsley.Los avances tecnológicos, particular relacionados la Neurofisiología y, más recientemente, Neuroimagen, han dado herramientas permitir un mejor conocimiento límites estructurales, así como funciones corticales una clara referencia respecto relación eventuales lesiones...