A5063250140- Epilepsy research and treatment
- Microtubule and mitosis dynamics
- Pharmacological Effects and Toxicity Studies
- Cannabis and Cannabinoid Research
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Psychedelics and Drug Studies
- Migraine and Headache Studies
- Child Nutrition and Feeding Issues
- Functional Brain Connectivity Studies
- Telemedicine and Telehealth Implementation
- Neuroscience of respiration and sleep
- Psychosomatic Disorders and Their Treatments
- Alcohol Consumption and Health Effects
- Healthcare Systems and Technology
- Atomic and Subatomic Physics Research
- Treatment of Major Depression
- Genomics and Rare Diseases
- Anesthesia and Sedative Agents
- Boron Compounds in Chemistry
- Genetic and Kidney Cyst Diseases
- Head and Neck Anomalies
- Tuberous Sclerosis Complex Research
- Alcoholism and Thiamine Deficiency
Wake Forest University
2024-2025
University of Toronto
2016-2024
Hospital for Sick Children
2016-2024
SickKids Foundation
2016-2024
Occupational Cancer Research Centre
2022
McGill University
2022
Deleted Institution
2022
Huntsman (United States)
2021
Montreal Neurological Institute and Hospital
2018
Miami Children's Hospital
2015-2016
To report the feasibility, safety, and clinical outcomes of an exploratory study MR-guided Laser Interstitial Thermal Therapy (MRgLITT) as a minimally invasive surgical procedure for ablation epileptogenic foci in children with drug-resistant, lesional epilepsy.Retrospective chart review all MRgLITT procedures at single tertiary care center. All were performed using U.S. Food Drug Administration (FDA)-cleared laser system (Visualase System). Predefined variables extracted from archived...
Abstract Objective To develop and validate a model to predict seizure freedom in children undergoing cerebral hemispheric surgery for the treatment of drug‐resistant epilepsy. Methods We analyzed 1267 surgeries performed pediatric participants across 32 centers 12 countries identify predictors at 3 months after surgery. A multivariate logistic regression was developed based on 70% dataset (training set) validated 30% (validation set). Missing data were handled using multiple imputation...
This detailed case report explores the application of ketamine-assisted psychotherapy (KAP) in treatment a 39-year-old male patient with Generalized Anxiety Disorder (GAD) and depressive symptoms. The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine represents significant breakthrough mood anxiety disorders due to its rapid robust antidepressant effects. Preclinical studies demonstrate that promotes biological alterations brain, including enhancing neuroplasticity. However, no date...
This study was undertaken to determine whether the vertical parasagittal approach or lateral peri-insular/peri-Sylvian hemispheric surgery is superior technique in achieving long-term seizure freedom. We conducted a post hoc subgroup analysis of HOPS (Hemispheric Surgery Outcome Prediction Scale) study, an international, multicenter, retrospective cohort that identified predictors freedom through logistic regression modeling. Only patients undergoing parasagittal, peri-insular/peri-Sylvian,...
Although hemispheric surgeries are among the most effective procedures for drug-resistant epilepsy (DRE) in pediatric population, there is a large variability seizure outcomes at group level. A recently developed HOPS score provides individualized estimation of likelihood freedom to complement clinical judgement. The objective this study was develop freely accessible online calculator that accurately predicts probability any patient 1-, 2-, and 5-years post-hemispherectomy. Retrospective...
OBJECTIVE Insular lobe epilepsy (ILE) is an under-recognized cause of extratemporal and explains some surgery failures in children with drug-resistant epilepsy. The diagnosis ILE usually requires invasive investigation insular sampling; however, the location insula below opercula dense middle cerebral artery vasculature renders its sampling challenging. Several techniques have been described, ranging from open direct placement orthogonal subpial depth strip electrodes through a craniotomy to...
Magnetic Resonance-guided Laser Interstitial Thermal Therapy (MRgLITT) is an emerging minimally-invasive alternative to resective surgery for medically-intractable epilepsy. The precise lesioning effect produced by MRgLITT supplies opportunities glean insights into epileptogenic regions and their interactions with functional brain networks. In this exploratory analysis, we sought characterize associations between ablation zones large-scale networks that portended seizure outcome using...
disease.Gastrectomized patients seem to be especially prone develop such a myopathy in view of the high frequency calcium dis- orders after gastric operations.However, complete recovery may follow upon treat- ment with vitamin D. The early diagnosis cases is therefore practical importance.-Weare, etc.,
Introduction Cannabis products have been used in the management of headaches adults and may play a role pediatric chronic pain. Canadian pediatricians report increasing use cannabis for headaches, despite no well-controlled studies to inform its dosing, safety, effectiveness. The aim our clinical trial is determine dosing safety Cannabidiol (CBD)-enriched Herbal Extract (CHE) treatment adolescents. Methods analysis Youth, parents, an expert steering committee co-designed this tolerability...
Key points Children with chronic debilitating illness and pain are increasingly using cannabis for medical purposes, particularly when conventional treatment options have limited benefit or substantial adverse effects. Caregivers becoming aware of evidence that suggests provides
Functional seizures, a primary subtype of functional neurological disorder (FND), are known cause serious disability with an increasing awareness their impact amongst the neuroscience community. Situated at intersection neurology and psychiatry, FND is characterized by range alterations in motor, sensory or cognitive performance, such as abnormal movements, limb weakness, dissociative, seizure-like episodes. seizures known, part, to have psychological underpinnings; however, lack effective...
Psychedelic-assisted therapy (PAT) may treat various mental health conditions. Despite its promising therapeutic signal across outcomes, less attention is paid on potential to provide benefits complex medical situations within rehabilitation medicine. Persons with spinal cord injury (SCI) have a high prevalence of treatment-resistant comorbidities that compound the extent their physical disability. Reports from online discussion forums suggest those living SCI are using psychedelics, though...
ABSTRACT: We present five cases of pediatric drug-resistant epilepsy (DRE) that failed management using high cannabidiol (CBD) doses, but had significant reduction in seizure frequency with reintroduction or increasing doses tetrahydrocannabinol (THC). There is growing evidence supporting the use whole-plant CBD-rich extracts (containing THC and other cannabinoids) treatment DRE. Based on our experiences reports literature, we propose that, patients who fail an initial trial high-dose...
Introduction Neurology wait times — from referral to consultation continue grow, leading various adverse effects on patient outcomes. Key elements of virtual care can be leveraged improve efficiency. This study examines the implementation a novel model – Virtual Rapid Access Clinics at Centre Toronto. The employs patient-centred workflow, involving multidisciplinary staff and online administrative tools that are synthesized expedite maintain quality. Methods Clinic efficacy was studied by...
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Childhood neurodegenerative diseases often pose a challenge to clinicians diagnose because of the degree genetic heterogeneity and variable presentations. Here, we present child with progressive neurodegeneration consisting spasticity, dystonia, ataxia in which postmortem pathological analysis led diagnosis interferon regulatory factor 2 binding protein like (IRF2BPL)-related disorder.