A5088402282- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Vagus Nerve Stimulation Research
- Autism Spectrum Disorder Research
- Cardiac electrophysiology and arrhythmias
- Traumatic Brain Injury Research
- Advanced MRI Techniques and Applications
- Neonatal and fetal brain pathology
- Face Recognition and Perception
- Ion channel regulation and function
- Infant Development and Preterm Care
- bioluminescence and chemiluminescence research
- Photoreceptor and optogenetics research
- Anesthesia and Neurotoxicity Research
- Neuroscience and Music Perception
- Advanced Neuroimaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Ion Transport and Channel Regulation
- Neural and Behavioral Psychology Studies
- Advanced Memory and Neural Computing
- Attention Deficit Hyperactivity Disorder
University of Toronto
2016-2024
Hospital for Sick Children
2014-2024
SickKids Foundation
2013-2022
Mental Health Research Canada
2018-2021
Objective Vagus nerve stimulation (VNS) is a common treatment for medically intractable epilepsy, but response rates are highly variable, with no preoperative means of identifying good candidates. This study aimed to predict VNS using structural and functional connectomic profiling. Methods Fifty‐six children, comprising discovery (n = 38) validation 18) cohorts, were recruited from 3 separate institutions. Diffusion tensor imaging was used identify group differences in white matter...
Although chronic vagus nerve stimulation (VNS) is an established treatment for medically-intractable childhood epilepsy, there considerable heterogeneity in seizure response and little data are available to pre-operatively identify patients who may benefit from treatment. Since the therapeutic effect of VNS be mediated by afferent projections thalamus, we tested hypothesis that intrinsic thalamocortical connectivity associated with following children epilepsy. Twenty-one (ages 5-21 years)...
Autism spectrum disorder (ASD) is a neurodevelopmental characterized by impairments in social cognition. The biological basis of deficits cognition ASD, and their difficulty processing emotional face information particular, remains unclear. Atypical communication within between brain regions has been reported ASD. Interregional phase-locking neurophysiological mechanism mediating among areas understood to support cognitive functions. In the present study we investigated interregional...
Detailed characterization of typical human neurodevelopment is key if we are to understand the nature mental and neurological pathology. While research on cellular processes has made great advances, in vivo imaging crucial our uniquely capabilities, as well pathologies that affect them. Using magnetoencephalography data largest normative sample currently available (324 participants aged 6-45 years), assess developmental trajectory resting-state oscillatory power functional connectivity from...
Working Memory (WM) supports a wide range of cognitive functions, and is positively associated with academic achievement. Although fMRI studies have revealed WM networks in adults, little known about how these develop to support successful performance children. Using magnetoencephalography, we examined the underlying maintenance visual information 6-year-old We observed an increase mean whole-brain connectivity that was specific alpha frequency band during retention interval correct compared...
Concussion is a common form of mild traumatic brain injury (mTBI). Despite the descriptor 'mild', single can leave long-lasting and sustained alterations to function, including changes localised activity large-scale interregional communication. Cognitive complaints are thought arise from such functional deficits. We investigated impact on neurophysiological functionally-specialised resting networks, known as intrinsic connectivity networks (ICNs), using magnetoencephalography (MEG). assessed...
Individuals with autism spectrum disorder (ASD) demonstrate poor social functioning, which may be related to atypical emotional face processing. Altered functional connectivity among brain regions, particularly involving limbic structures implicated. The current magnetoencephalography (MEG) study investigated whole-brain of eight a priori identified regions during the implicit presentation happy and angry faces in 20 7–10-year-old children ASD 22 typically developing controls. Findings...
Abstract Children with epilepsy commonly have comorbid neurocognitive impairments that severely affect their psychosocial well‐being, education, and future career prospects. Although the provenance of these deficits is multifactorial, effects interictal epileptiform discharges (IEDs) anti‐seizure medications (ASMs) are thought to be particularly severe. certain ASMs can leveraged inhibit IED occurrence, it remains unclear whether or themselves most deleterious cognition. To examine this...
The chloride channel ClC-2 has been implicated in essential physiological functions, including cell-volume regulation and fluid secretion by specific epithelial tissues. Although is known to be activated hyperpolarization hypo-osmotic shock, the molecular basis for of this remains unclear. Here we show Xenopus oocyte expression system that chloride-channel activity enhanced after treatment with actin-disrupting agents cytochalasin latrunkulin. These findings suggest actin cytoskeleton...
Millions of North Americans sustain a concussion or mild traumatic brain injury annually, and are at risk cognitive, emotional, physical sequelae. Although functional MRI (fMRI) studies have provided an initial framework for examining deficits induced by concussion, particularly working memory attention, the temporal dynamics underlying these not well understood. We used magnetoencephalography (MEG), modality with millisecond resolution, in conjunction 1-back visual (VWM) paradigm using...
There is an unmet need to develop robust predictive algorithms preoperatively identify pediatric epilepsy patients who will respond vagus nerve stimulation (VNS). Given the similarity in neural circuitry between and median afferent projections primary somatosensory cortex, current study hypothesized that evoked field(s) (SEFs) could be used predict seizure response VNS. Retrospective data from forty-eight underwent VNS at two different institutions were this study. Thirty-six (“Discovery...
Abstract In focal ictogenesis, gamma oscillations (30–70 Hz) recorded by electroencephalography (EEG) are related to the epileptiform synchronization of interneurons that links seizure onset zone (SOZ) surrounding epileptogenic zone. We hypothesized could be detected as changes in regularity oscillation rhythmicity. used multiscale entropy (MSE) analysis, which can quantify EEG rhythmicity, investigate how over course a event. analyzed intracranial data from 13 pediatric patients with...
Summary Objective Spike and slow waves consist of a “spike” including high‐frequency oscillations ( HFO s), which are linked to epileptogenicity “post–spike wave PSS )” related inhibitory activity. The aim this study was elucidate the spatiotemporal relationship between spike‐related s in patients with focal cortical dysplasia FCD ) type II . Methods We studied 10 pediatric , who underwent extraoperative video–electroencephalography EEG) selected spike waves, included (80–200 Hz), performed...
Abstract Objective Seizure recurrence following surgery for temporal lobe (TL) epilepsy may be related to extratemporal epileptogenic foci, so‐called temporal‐plus (TL+) epilepsy. Here, we sought leverage whole brain connectomic profiling in magnetoencephalography (MEG) identify neural networks indicative of TL+ children. Methods Clinical and MEG data were analyzed 121 children with TL spanning 20 years at the Hospital Sick Children. Resting‐state connectomes derived using weighted phase lag...
Post-traumatic stress disorder (PTSD) is associated with heightened responses to threatening stimuli, particularly aggression-related emotional facial expressions. The stability over time of this neurophysiological 'hyperactive' threat response has not been determined. We studied implicit face processing in soldiers and without PTSD at two time-points (roughly 2 years apart) using magnetoencephalography determine the oscillations synchrony happy angry faces, reliability marker for time. At...
Magnetic Resonance-guided Laser Interstitial Thermal Therapy (MRgLITT) is an emerging minimally-invasive alternative to resective surgery for medically-intractable epilepsy. The precise lesioning effect produced by MRgLITT supplies opportunities glean insights into epileptogenic regions and their interactions with functional brain networks. In this exploratory analysis, we sought characterize associations between ablation zones large-scale networks that portended seizure outcome using...
Working memory deficits are prevalent in childhood epilepsy. processing is thought to be supported by the phase of hippocampal neural oscillations. Disruptions working have previously been linked occurrence transient epileptic activity. This study aimed resolve associations between oscillatory activity, epileptiform events, and children with epilepsy.Intracranial recordings were acquired from stereotactically implanted electrodes hippocampi, epileptogenic zones, memory-related networks...