A5048611712- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Autism Spectrum Disorder Research
- Genetic Neurodegenerative Diseases
- EEG and Brain-Computer Interfaces
- Parkinson's Disease Mechanisms and Treatments
- Cerebral Palsy and Movement Disorders
- Neuroscience and Neural Engineering
- Cerebrospinal fluid and hydrocephalus
- Congenital heart defects research
- Cancer therapeutics and mechanisms
- Obsessive-Compulsive Spectrum Disorders
- Acute Lymphoblastic Leukemia research
- Vagus Nerve Stimulation Research
- Family and Disability Support Research
- Head and Neck Surgical Oncology
- Childhood Cancer Survivors' Quality of Life
- Sleep and Wakefulness Research
- Coronary Artery Anomalies
- Assistive Technology in Communication and Mobility
- Voice and Speech Disorders
- Spinal Fractures and Fixation Techniques
- Attention Deficit Hyperactivity Disorder
- Spinal Cord Injury Research
- Fetal and Pediatric Neurological Disorders
Hospital for Sick Children
2019-2025
SickKids Foundation
2019-2025
University of Toronto
2019-2025
University of Alberta
2025
McMaster University
2022-2024
Impact
2022-2024
Ontario Brain Institute
2024
University Health Network
2024
Toronto Public Health
2024
Toronto Western Hospital
2020
Outcomes following vagus nerve stimulation (VNS) improve over years after implantation in children with drug‐resistant epilepsy. The added value of deep brain (DBS) instead continued VNS optimization is unknown. In a prospective, non‐blinded, randomized patient preference trial 18 (aged 8–17 years) who did not respond to at least 1 year, add‐on DBS resulted greater seizure reduction compared an additional year (51.9% vs. 12.3%, p = 0.047). Add‐on also less bothersome seizures ( 0.03), but no...
Deep brain stimulation of the centromedian nucleus thalamus (CM-DBS) is an investigational, off-label treatment for drug-resistant epilepsy (DRE) in children. Although emerging evidence supports its safety and efficacy select indications, effect CM-DBS on quality life functional outcomes such as school attendance has not been studied. Here, we analyzed data from prospective CHILD-DBS (Child & Youth Comprehensive Longitudinal Database Brain Stimulation) to examine impact patient-...
Programming deep brain stimulation (DBS) is still based on a trial-and-error approach, often becoming time-consuming process for both treating physicians and patients. Several strategies have been proposed to streamline DBS programming, most of which are preliminary mainly address Parkinson's disease, condition readily responsive adjustments. In the present proof-of-principle pilot study, we successfully demonstrate that local field potential (LFP)-based programming can be an effective...
We sought to better understand the workflow, outcomes, and complications of deep brain stimulation (DBS) for pediatric status dystonicus (SD). present a systematic review, alongside multicenter case series patients with SD treated DBS.We collected individual data regarding treatment, parameters, dystonia severity (n = 8) all previously published cases 77). Data were used create probabilistic voxelwise maps stimulated tissue associated improvement.In our institutional series, DBS was...
OBJECTIVE Functional hemispherectomy is an effective surgical intervention for select patients with drug-resistant epilepsy. The last several decades have seen dramatic evolutions in preoperative evaluation, techniques, and postoperative care. Here, the authors present a retrospective review of medical records 146 children who underwent between 1987 2022 at Hospital Sick Children, providing unique overview evolution procedure patient outcomes over 35 years. METHODS all Children were...
Children and youth with autism spectrum disorder (ASD) may manifest self-injurious behaviors (SIB) that become severe refractory limited pharmacologic or behavioral treatment options. Here, we present the protocol of a prospective, mixed-methods study to assess safety efficacy deep brain stimulation (DBS) nucleus accumbens (NAcc) for children ASD severe, SIB.This is single-center, single-cohort, open-label, non-randomized pilot trial 6 patients. Participants will be recruited through...
This study aims to glean patient and caregiver perspectives surrounding deep brain stimulation (DBS) in children youth through an analysis of patterns social media usage.The authors performed a comprehensive search the Twitter Application Programming Interface (API) database for all tweets about DBS use youth, with no date restriction. Data pertaining each tweet were extracted analysis. Results analyzed using qualitative quantitative methodologies. These included thematic tweets, accounts,...
Abstract Aim To describe the experiences of children with self‐injurious behavior (SIB) through lens family caregivers to inform development relevant interventions. Method SIB in autism spectrum disorder is challenging understand and manage. Furthermore, our understanding impact on families limited. We performed an exploratory qualitative study using interpretive description methodology. Semi‐structured one‐on‐one interviews were conducted as primary data collection technique. A purposive...
BACKGROUND Cervical spine injuries in neonates are rare and no guidelines available to inform management. The most common etiology of neonatal cervical injury is birth-related trauma. Management strategies that routine older children adults not feasible due the unique anatomy neonates. OBSERVATIONS Here, authors present 3 cases spinal confirmed or suspected birth trauma, 2 whom presented immediately after birth, while other was diagnosed at 7 weeks age. One child with neurological deficits...
In nonambulatory children with predominantly spastic cerebral palsy (CP), the authors compared care needs, symptom burden, and complications after surgical treatment either intrathecal baclofen (ITB) pump insertion or selective dorsal rhizotomy (SDR). The patients were treated at two Canadian centers variability in practice pertaining to these options.
L-2-hydroxyglutaric aciduria (L2HGA) is a rare neurometabolic disorder marked by progressive and debilitating psychomotor deficits. Here, we report the first patient with L2HGA-related refractory dystonia that was managed deep brain stimulation to bilateral globus pallidus internus (GPi-DBS).