A5080757364- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Vagus Nerve Stimulation Research
- Botulinum Toxin and Related Neurological Disorders
- Vehicle Noise and Vibration Control
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Pharmacological Effects and Toxicity Studies
- Cerebrospinal fluid and hydrocephalus
- Transcranial Magnetic Stimulation Studies
- Attention Deficit Hyperactivity Disorder
- Electric and Hybrid Vehicle Technologies
- Control Systems in Engineering
- Neonatal and fetal brain pathology
- Pain Management and Treatment
- Fetal and Pediatric Neurological Disorders
- Radiomics and Machine Learning in Medical Imaging
- Acoustic Wave Phenomena Research
- COVID-19 and healthcare impacts
- Ophthalmology and Eye Disorders
- Machine Learning in Healthcare
- Renal cell carcinoma treatment
Hospital for Sick Children
2022-2025
SickKids Foundation
2022-2025
University of Toronto
2022-2025
Ontario Brain Institute
2025
FEV (Germany)
2022
Health Sciences Centre
2020
Sunnybrook Research Institute
2020
Sunnybrook Health Science Centre
2020
Epilepsy is a common and debilitating neurological disorder, approximately one-third of affected individuals have ongoing seizures despite appropriate trials two anti-seizure medications. This population with drug-resistant epilepsy (DRE) may benefit from neurostimulation approaches, such as vagus nerve stimulation (VNS), deep brain (DBS) responsive (RNS). In some patient populations, these techniques are FDA-approved for treating DRE. VNS used adjuvant therapy children adults. Acting via...
Outcomes following vagus nerve stimulation (VNS) improve over years after implantation in children with drug‐resistant epilepsy. The added value of deep brain (DBS) instead continued VNS optimization is unknown. In a prospective, non‐blinded, randomized patient preference trial 18 (aged 8–17 years) who did not respond to at least 1 year, add‐on DBS resulted greater seizure reduction compared an additional year (51.9% vs. 12.3%, p = 0.047). Add‐on also less bothersome seizures ( 0.03), but no...
Deep brain stimulation of the centromedian nucleus thalamus (CM-DBS) is an investigational, off-label treatment for drug-resistant epilepsy (DRE) in children. Although emerging evidence supports its safety and efficacy select indications, effect CM-DBS on quality life functional outcomes such as school attendance has not been studied. Here, we analyzed data from prospective CHILD-DBS (Child & Youth Comprehensive Longitudinal Database Brain Stimulation) to examine impact patient-...
Abstract Children with epilepsy commonly have comorbid neurocognitive impairments that severely affect their psychosocial well‐being, education, and future career prospects. Although the provenance of these deficits is multifactorial, effects interictal epileptiform discharges (IEDs) anti‐seizure medications (ASMs) are thought to be particularly severe. certain ASMs can leveraged inhibit IED occurrence, it remains unclear whether or themselves most deleterious cognition. To examine this...
Gelastic seizures due to hypothalamic hamartomas (HH) are challenging treat, in part an incomplete understanding of seizure propagation pathways. Although magnetic resonance imaging-guided laser interstitial thermal therapy (MRgLITT) is a promising intervention disconnect HH from ictal networks, the optimal site ablation achieve freedom not known. In this study, we investigated intraoperative post-ablation changes resting-state functional connectivity identify large-scale networks associated...
OBJECTIVE Functional hemispherectomy is an effective surgical intervention for select patients with drug-resistant epilepsy. The last several decades have seen dramatic evolutions in preoperative evaluation, techniques, and postoperative care. Here, the authors present a retrospective review of medical records 146 children who underwent between 1987 2022 at Hospital Sick Children, providing unique overview evolution procedure patient outcomes over 35 years. METHODS all Children were...
Abstract OpenAI’s large multimodal model, GPT-4V(ision), was recently developed for general image interpretation. However, less is known about its capabilities with medical interpretation and diagnosis. Board-certified physicians senior residents assessed GPT-4V’s proficiency across a range of conditions using imaging modalities such as CT scans, MRIs, ECGs, clinical photographs. Although GPT-4V able to identify explain images, diagnostic accuracy decision-making abilities are poor, posing...
Neurocognitive outcomes after surgery for temporal lobe epilepsy in childhood are variable. Postoperative changes not directly predicted by seizure freedom, and associations between epilepsy, neuropsychological function, developing neural networks poorly understood. Here, we leveraged whole-brain connectomic profiling magnetoencephalography (MEG) to retrospectively study brain connectivity function children with undergoing resective surgery.Clinical MEG data were analyzed who underwent at...
The theory of transient cognitive impairment in epilepsy posits that lapses attention result from ephemeral disruption attentional circuitry by interictal events. Eye movements are intimately associated with human and can be monitored real time using eye-tracking technologies. Here, we sought to characterize the associations between epileptiform discharges (IEDs), gaze, behavior children epilepsy.Eleven consecutive undergoing invasive monitoring stereotactic electrodes for...
Vagus nerve stimulation (VNS) is a neuromodulation therapy that can reduce the seizure burden of children with medically intractable epilepsy. Despite widespread use VNS to treat epilepsy, there are currently no means preoperatively identify patients who will benefit from treatment. The objective present study determine clinical and neural network-based correlates treatment outcome better candidates for therapy. In this multi-institutional North American study, undergoing their caregivers be...
Abstract Background Cerebellar mutism syndrome (CMS) is a common and debilitating complication of posterior fossa tumor surgery in children. Affected children exhibit communication social impairments that overlap phenomenologically with subsets deficits exhibited by Autism spectrum disorder (ASD). Although both CMS ASD are thought to involve disrupted cerebro-cerebellar circuitry, they considered independent conditions due an incomplete understanding their shared neural substrates. Methods...
Despite decades of clinical usage, selection patients with drug resistant epilepsy who are most likely to benefit from vagus nerve stimulation (VNS) remains a challenge. The mechanism action VNS is dependent upon afferent brainstem circuitry, which comprises critical component the Vagus Afferent Network (VagAN). To evaluate association between circuitry and seizure response, we retrospectively collected intraoperative data sub-cortical recordings somatosensory evoked potentials (SSEP) in 7...