A5027255034- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Obsessive-Compulsive Spectrum Disorders
- EEG and Brain-Computer Interfaces
- Botulinum Toxin and Related Neurological Disorders
- Advanced MRI Techniques and Applications
- Global Public Health Policies and Epidemiology
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Cerebral Venous Sinus Thrombosis
- Autism Spectrum Disorder Research
- Stroke Rehabilitation and Recovery
- Infectious Encephalopathies and Encephalitis
- Neuroethics, Human Enhancement, Biomedical Innovations
- Migraine and Headache Studies
- Glaucoma and retinal disorders
- Cardiovascular Health and Risk Factors
- Neuroscience and Neuropharmacology Research
- Cerebral Palsy and Movement Disorders
- Ophthalmology and Eye Disorders
Charité - Universitätsmedizin Berlin
2018-2025
Humboldt-Universität zu Berlin
2018-2025
Freie Universität Berlin
2018-2025
Nahrain University
2017
Baghdad Medical City
2016
Abstract Multiple surgical targets for treating obsessive-compulsive disorder with deep brain stimulation (DBS) have been proposed. However, different may modulate the same neural network responsible clinical improvement. We analyzed data from four cohorts of patients ( N = 50) that underwent DBS to anterior limb internal capsule (ALIC), nucleus accumbens or subthalamic (STN). The fiber bundle was associated optimal response in targeting either structure. This connected frontal regions STN....
Adaptive deep brain stimulation (aDBS) is a promising concept for feedback-based neurostimulation, with the potential of clinical implementation sensing-enabled Percept neurostimulator. We aim to characterize chronic electrophysiological activity during and validate beta-band as biomarker bradykinesia. Subthalamic was recorded stepwise amplitude increase OFF medication in 10 Parkinson's patients rest finger tapping. Offline analysis wavelet-transformed assessment inter-variable relationships...
Following its introduction in 2014 and with support of a broad international community, the open-source toolbox Lead-DBS has evolved into comprehensive neuroimaging platform dedicated to localizing, reconstructing, visualizing electrodes implanted human brain, context deep brain stimulation (DBS) epilepsy monitoring. Expanding clinical indications for DBS, increasing availability related research tools, growing community clinician-scientist researchers, however, have led an ongoing need...
Al-Fatly et al. establish predictive connectivity maps of deep brain stimulation in essential tremor. They demonstrate that electrode to tremor-associated areas can predict postoperative improvement and these be somatotopically segregated according the tremor-affected body parts.
Current efforts to optimise subthalamic deep brain stimulation in Parkinson's disease patients aim harness local oscillatory activity the beta frequency range (13–35 Hz) as a feedback-signal for demand-based adaptive paradigms. A high prevalence of peak is prerequisite this approach become routine clinical practice. In large dataset postoperative rest recordings from 106 we quantified occurrence and identified determinants spectral peaks alpha, low bands. At least one band occurred 92% 84%...
Dystonia is a debilitating disease with few treatment options. One effective option deep brain stimulation (DBS) to the internal pallidum. While cervical and generalized forms of isolated dystonia have been targeted common approach posterior third nucleus, large-scale investigations regarding optimal sites potential network effects not carried out. Here, we retrospectively studied clinical results following DBS for in multicenter cohort 80 patients. We model electrode placement based on pre-...
Deep brain stimulation is an efficacious treatment for dystonia. While the internal pallidum serves as primary target, recently, of subthalamic nucleus (STN) has been investigated. However, optimal targeting within this structure and its surroundings have not studied in depth. Indeed, historical targets that used surgical dystonia are directly adjacent to STN. Further, multiple types exist, outcomes variable, suggesting all would profit maximally from same target. Therefore, a thorough...
Abstract The subthalamic nucleus and internal pallidum are main target sites for deep brain stimulation in Parkinson’s disease. Multiple trials that investigated versus pallidal were unable to settle on a definitive optimal between the two. One reason could be effect is mediated via common functional network. To test this hypothesis, we calculated connectivity profiles seeding from electrodes 94 patients underwent 28 with treatment based normative connectome atlas 1000 healthy subjects. In...
With a growing appreciation for interindividual anatomical variability and patient-specific brain connectivity, advanced imaging sequences offer the opportunity to directly visualize targets deep stimulation (DBS). The lack of quantitative evidence demonstrating their clinical utility, however, has hindered broad implementation in practice.Using fast gray matter acquisition T1 inversion recovery (FGATIR) sequences, present study identified thalamic hypointensity that holds promise as visual...
The objective of this study was to obtain individual clinical and neuroimaging data patients undergoing deep brain stimulation (DBS) for essential tremor (ET) from 5 different European centers identify predictors outcome an optimal site.We analyzed retrospectively baseline covariates, pre- postoperative scores (for 12 months) as well imaging 119 electrode positions volumes. Individual were used calculate a probabilistic map in normalized space using voxel-wise statistical analysis. Finally,...
Tics are sudden stereotyped movements or vocalizations. Cases of lesion-induced tics invaluable, allowing for causal links between symptoms and brain structures. While a lesion network has recently been identified, the degree to which this translates Tourette syndrome not fully elucidated. This is important given that patients with make up large portion tic cases; therefore, existing future treatments should apply these patients. The aim study was first localize from cases then refine...
Background: Additional stimulation of the substantia nigra (SNr) has been proposed to target axial symptoms and gait impairment in patients with Parkinson’s disease (PD). Objective: This study aimed characterize effects combined deep brain (DBS) subthalamic nucleus (STN) SNr on performance PD map sites within SNr. Methods: In a double-blinded crossover design, 10 underwent clinical examination kinematic assessment STN DBS, STN+SNr DBS OFF 30 minutes after reprogramming. To confirm SNr,...
Comparatively high excitability of myelinated fibers suggests that they represent a major mediator deep brain stimulation effects. Such effects can be modeled using different levels abstraction, ranging from simple electric field estimates to complex multicompartment axon models. In this study, we explore three approaches estimate axonal activation: magnitudes, projections and (probabilistic) pathway activation modeling. Our aim is describe these also illustrate their relevance. For that,...
Subthalamic deep brain stimulation (STN-DBS) provides unprecedented spatiotemporal precision for the treatment of Parkinson's disease (PD), allowing direct real-time state-specific adjustments. Inspired by findings from optogenetic in mice, we hypothesized that STN-DBS effects on movement speed depend ongoing kinematics patients exhibit during stimulation. To investigate this hypothesis, implemented a motor state-dependent closed-loop neurostimulation algorithm, adapting DBS burst delivery...
Abstract Deep brain stimulation is a circuit intervention that can modulate distinct neural pathways for the alleviation of neurological symptoms in patients with disorders. In Parkinson’s disease, subthalamic deep clinically mimics effect dopaminergic drug treatment, but shared pathway mechanisms on cortex – basal ganglia networks are unknown. To address this critical knowledge gap, we combined fully invasive multisite recordings undergoing surgery normative MRI-based whole-brain...
Deep brain stimulation (DBS) is an established treatment in patients of various ages with pharmaco-resistant neurological disorders. Surgical targeting and postoperative programming DBS depend on the spatial location stimulating electrodes relation to surrounding anatomical structures, electrode connectivity a specific distribution pattern within networks. Such information usually collected using group-level analysis, which relies availability normative imaging resources (atlases...
Abstract Thalamic aphasia results from focal thalamic lesions that cause dysfunction of remote but functionally connected cortical areas due to language network perturbation. However, specific local and network-level neural substrates remain incompletely understood. Using lesion symptom mapping, we demonstrate in the left ventrolateral ventral anterior nucleus are most strongly associated with general impaired semantic phonemic fluency complex comprehension particular. Lesion mapping (using...
Postoperative delirium (POD) is a serious complication following deep brain stimulation (DBS) but only received little attention. Its main risk factors are higher age and preoperative cognitive deficits. These also for long-term decline after DBS in Parkinson's disease (PD).