A5054591613- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Obsessive-Compulsive Spectrum Disorders
- Functional Brain Connectivity Studies
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Advanced Neuroimaging Techniques and Applications
- Voice and Speech Disorders
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Autism Spectrum Disorder Research
- Non-Invasive Vital Sign Monitoring
- Atrial Fibrillation Management and Outcomes
- Neural dynamics and brain function
- Cerebrovascular and genetic disorders
- ECG Monitoring and Analysis
- Epilepsy research and treatment
- Heart Rate Variability and Autonomic Control
- Medical Imaging and Pathology Studies
- Long-Term Effects of COVID-19
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cerebral Venous Sinus Thrombosis
- Neurogenetic and Muscular Disorders Research
University of Cologne
2016-2025
University Hospital Cologne
2016-2025
Brigham and Women's Hospital
2024-2025
Harvard University
2025
Circuit Therapeutics (United States)
2024
Universitätsklinikum Gießen und Marburg
2024
University of Freiburg
2024
Klinik und Poliklinik für Neurologie
2023
Centrum für Integrierte Onkologie
2022
Leibniz Institute for Neurobiology
2018
ABSTRACT Objective The objective of this study was to investigate whether directional deep brain stimulation (DBS) the subthalamic nucleus in Parkinson's disease (PD) offers increased therapeutic windows, side‐effect thresholds, and clinical benefit. Methods In 10 patients, 20 monopolar reviews were conducted a prospective, randomized, double‐blind design identify best directions compare them conventional circular DBS regarding motor improvement, window. addition, best‐directional directly...
Objective To investigate whether functional sweet spots of deep brain stimulation (DBS) in the subthalamic nucleus (STN) can predict motor improvement Parkinson disease (PD) patients. Methods Stimulation effects 449 DBS settings 21 PD patients were clinically and quantitatively assessed through standardized monopolar reviews mapped into standard space. A spot for best outcome was determined using voxelwise nonparametric permutation statistics. Two independent cohorts used to overlap with...
Following its introduction in 2014 and with support of a broad international community, the open-source toolbox Lead-DBS has evolved into comprehensive neuroimaging platform dedicated to localizing, reconstructing, visualizing electrodes implanted human brain, context deep brain stimulation (DBS) epilepsy monitoring. Expanding clinical indications for DBS, increasing availability related research tools, growing community clinician-scientist researchers, however, have led an ongoing need...
Abstract Frontal circuits play a critical role in motor, cognitive and affective processing, their dysfunction may result variety of brain disorders. However, exactly which frontal domains mediate (dys)functions remains largely elusive. We studied 534 deep stimulation electrodes implanted to treat four different By analyzing connections were modulated for optimal therapeutic response across these disorders, we segregated the cortex into that had become dysfunctional each them. Dysfunctional...
Abstract Deep Brain Stimulation can improve tremor, bradykinesia, rigidity, and axial symptoms in patients with Parkinson’s disease. Potentially, improving each symptom may require stimulation of different white matter tracts. Here, we study a large cohort (N = 237 from five centers) to identify tracts associated improvements the four domains. Tremor were connected primary motor cortex cerebellum. In contrast, are supplementary brainstem. Bradykinesia rigidity premotor cortices,...
<h3>Objective</h3> To evaluate deep brain stimulation (DBS) of the posterior subthalamic area (PSA) in essential tremor (ET) and compare it to ventral intermediate nucleus thalamus (VIM) terms efficacy, efficiency, side effects. <h3>Methods</h3> DBS leads were implanted such that contacts placed VIM, on intercommissural line, PSA. Thirteen patients with ET entered a randomized, double-blind crossover phase completed 1-year follow-up. <h3>Results</h3> PSA-DBS significantly reduced severity...
Deep brain stimulation of the subthalamic nucleus improves non-motor symptoms in Parkinson’s disease, but with considerable inter-individual variability. Petry-Schmelzer et al. show that neurostimulation specific subregions has differential effects on mood/apathy, attention/memory and sleep-related outcomes. Neurostimulation could thus be tailored to patients’ individual profiles.
To create probabilistic stimulation maps (PSMs) of deep brain (DBS) effects on tremor suppression and stimulation-induced side-effects in patients with essential (ET). Monopolar reviews from 16 ET-patients which consisted over 600 settings were used to PSMs. A spherical model the volume neural activation was estimate spatial extent DBS for each setting. All data pooled voxel-wise statistical analysis as well nonparametric permutation testing confirm validity PSMs showed be more pronounced by...
Abstract Background: The objective of this study was to investigate 24‐month effects bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) on nonmotor symptoms in Parkinson's disease (PD). Methods: In prospective, observational, multicenter, international including 67 PD patients undergoing STN‐DBS, we examined the Non‐motor Symptom Scale, Non‐Motor Symptoms Questionnaire, Disease Questionnaire‐8, Scales for Outcomes Disease‐motor examination, ‐activities daily living, and...
Abstract Most research in Parkinson’s disease focuses on improving motor symptoms. Yet, up to 80% of patients present with non-motor symptoms that often have a large impact patients’ quality life. Impairment working memory, fundamental cognitive process, is common Parkinson's disease. While deep brain stimulation (DBS) the subthalamic nucleus (STN) improves disease, its functions less well studied. Here, we examine effect DBS theta, beta, low and high gamma frequency memory 20 bilateral...
Deep brain stimulation is an efficacious treatment for dystonia. While the internal pallidum serves as primary target, recently, of subthalamic nucleus (STN) has been investigated. However, optimal targeting within this structure and its surroundings have not studied in depth. Indeed, historical targets that used surgical dystonia are directly adjacent to STN. Further, multiple types exist, outcomes variable, suggesting all would profit maximally from same target. Therefore, a thorough...
To investigate in patients with essential tremor (ET) treated thalamic/subthalamic deep brain stimulation (DBS) whether stimulation-induced dysarthria (SID) can be diminished by individualized current-shaping interleaving (cs-ILS) while maintaining suppression (TS).Of 26 screened, 10 reported SID and were invited for testing. TS was assessed the Tremor Rating Scale kinematic analysis of postural action tremor. phonetic logopedic means. Additionally, rated their on a visual analog scale.In 6...
Directional deep brain stimulation (DBS) allows steering the in an axial direction which offers greater flexibility programming. However, accurate anatomical visualization of lead orientation is required for interpreting observed effects and to guide programming.In this study we aimed develop test robust algorithm determining segmented electrodes based on standard postoperative CT imaging used DBS.Orientation angles directional leads (CartesiaTM; Boston Scientific, Marlborough, MA, USA) were...
Purpose Orientating the angle of directional leads for deep brain stimulation ( DBS ) in an axial plane introduces a new degree freedom that is indicated by embedded anisotropic markers. Our aim was to develop algorithms determine lead orientation angles from computed tomography CT and stereotactic x‐ray imaging using standard clinical protocols, subsequently assess accuracy both methods. Methods In marker artifact taken as signature analyzed discrete Fourier transform circular intensity...
To investigate the relation between deep brain stimulation (DBS) of posterior-subthalamic-area (PSA) and ventral-intermediate-nucleus (VIM) distance to dentatorubrothalamic tract (DRTT) in essential tremor (ET).Tremor rating scale (TRS) hemi-scores were analyzed 13 ET patients, stimulated both VIM PSA a randomized, crossover trial. Distances contacts population-based DRTTs calculated. The relationships DRTT amplitude, as well DBS efficiency (TRS improvement per amplitude) investigated.PSA...
Abstract Background Effects of DBS on freezing gait and other axial signs in PD patients are unclear. Objective Secondary analysis to assess whether affects these symptoms within a large randomized controlled trial comparing the STN combined with best medical treatment alone early motor complications (EARLYSTIM‐trial). Methods One hundred twenty‐four were stimulation group 127 group. Presence was assessed worst condition based item‐14 UPDRS‐II at baseline follow‐up. The posture, instability,...
BackgroundDeep brain stimulation (DBS) of the thalamus can effectively reduce tics in severely affected patients with Tourette syndrome (TS). Its effect on cortical oscillatory activity is currently unknown.ObjectiveWe assessed whether DBS modulates beta at fronto-central electrodes. We explored concurrent EEG sources and probabilistic maps.MethodsResting state TS treated thalamic was recorded repeated DBS-on DBS-off states. A mixed linear model employed for statistical evaluation. were...
Background Clinical and ethical implications of personality mood changes in Parkinson's disease (PD) patients treated with subthalamic deep brain stimulation (STN-DBS) are under debate. Although subjectively perceived often mentioned by caregivers, few empirical studies concerning these exist. Therefore, we analysed STN-DBS PD patients. Method In this prospective study the ELSA-DBS group, 27 were assessed preoperatively 1 year after surgery. Two categories, changes, semi-structured...
Open questions remain regarding the optimal target, or sweetspot, for deep brain stimulation (DBS) in, example, Parkinson's disease. Previous studies introduced different methods of mapping DBS effects to determine sweetspots. While having a direct impact on surgical targeting and postoperative programming in DBS, these so far have not been compared.This study investigated five previously published approaches their potential correctly identify predefined target. Methods were silico eight...
Intra- and perioperatively recorded local field potential (LFP) activity of the nucleus subthalamicus (STN) has been suggested to guide contact selection in patients undergoing deep brain stimulation (DBS) for Parkinson’s disease (PD). Despite invention sensing capacities chronically implanted devices, a comprehensible algorithm that enables using such recordings is still lacking. We evaluated fully automated uses weighted average bipolar determine effective monopolar contacts based on...