A5027666885- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Neuroscience and Neural Engineering
- Epilepsy research and treatment
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Transcranial Magnetic Stimulation Studies
- Face Recognition and Perception
- Genetic Neurodegenerative Diseases
- Advanced Neuroimaging Techniques and Applications
- Nerve injury and regeneration
- Visual perception and processing mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Neurogenesis and neuroplasticity mechanisms
- Virus-based gene therapy research
- Pharmacological Effects and Toxicity Studies
- Obsessive-Compulsive Spectrum Disorders
- Vagus Nerve Stimulation Research
- Advanced MRI Techniques and Applications
- Memory and Neural Mechanisms
- Fetal and Pediatric Neurological Disorders
- Neuroscience and Music Perception
- RNA Interference and Gene Delivery
Harvard University
1908-2025
Massachusetts General Hospital
2019-2025
University of Pittsburgh Medical Center
2014-2024
Neurological Surgery
2015-2024
University of Pittsburgh
2015-2024
Massachusetts Institute of Technology
2022-2024
Institute of Cognitive and Brain Sciences
2023-2024
New England Institute for Neurology and Headache
2021-2024
Hokkaido University Hospital
2021-2024
Loma Linda University
2024
G protein-coupled receptors (GPCRs) are classically characterized as cell-surface transmitting extracellular signals into cells. Here we show that central components of a GPCR signaling system comprised the melatonin type 1 receptor (MT
Following its introduction in 2014 and with support of a broad international community, the open-source toolbox Lead-DBS has evolved into comprehensive neuroimaging platform dedicated to localizing, reconstructing, visualizing electrodes implanted human brain, context deep brain stimulation (DBS) epilepsy monitoring. Expanding clinical indications for DBS, increasing availability related research tools, growing community clinician-scientist researchers, however, have led an ongoing need...
Abstract Frontal circuits play a critical role in motor, cognitive and affective processing, their dysfunction may result variety of brain disorders. However, exactly which frontal domains mediate (dys)functions remains largely elusive. We studied 534 deep stimulation electrodes implanted to treat four different By analyzing connections were modulated for optimal therapeutic response across these disorders, we segregated the cortex into that had become dysfunctional each them. Dysfunctional...
Abstract Over the past decade, stereotactically placed electrodes have become gold standard for deep brain recording and stimulation a wide variety of neurological psychiatric diseases. Current electrodes, however, are limited in their spatial resolution ability to record from small populations neurons, let alone individual neurons. Here, we report on an innovative, customizable, monolithically integrated human-grade flexible depth electrode capable up 128 channels able at 10 cm tissue. This...
Abstract We evaluated whether spike ripples, the combination of epileptiform spikes and provide a reliable improved biomarker for epileptogenic zone compared with other leading interictal biomarkers in multicentre, international study. first validated an automated ripple detector on intracranial EEG recordings. then applied this to subjects from four centres who subsequently underwent surgical resection known 1-year outcomes. rate cured after [International League Against Epilepsy Class 1...
The National Association of Epilepsy Centers first published the guidelines for epilepsy centers in 1990, which were last updated 2010. Since that update, care and science guideline development have advanced significantly, including importance incorporating a diversity stakeholder perspectives such as those patients their caregivers. Currently, despite extensive data examining efficacy treatments diagnostic testing epilepsy, there remain significant gaps identifying essential services needed...
Clinical trials involving direct infusion of neurotrophic therapies for Parkinson's disease (PD) have suffered from poor coverage the putamen. The planned use a novel interventional-magnetic resonance imaging (iMRI) targeting system achieving precise, real-time convection-enhanced delivery in clinical trial adeno-associated virus serotype 2 (AAV2)-glial-derived factor (GDNF) PD patients was modeled nonhuman primates (NHP). NHP received bilateral coinfusions gadoteridol (Gd)/AAV2-GDNF into...
Significance A central issue in the neurobiology of reading is a debate regarding visual representation words, particularly left midfusiform gyrus (lmFG). Direct neural recordings, electrical brain stimulation, and pre-/postsurgical neuropsychological testing provided strong evidence that lmFG supports an orthographically specific “visual word form” system becomes specialized for orthographic knowledge. Machine learning elucidated dynamic role plays with early processing stage organized by...
Objective To understand the safety, putaminal coverage, and enzyme expression of adeno‐associated viral vector serotype‐2 encoding complementary DNA for enzyme, aromatic L‐amino acid decarboxylase (VY‐AADC01), delivered using novel intraoperative monitoring to optimize delivery. Methods Fifteen subjects (three cohorts 5) with moderately advanced Parkinson's disease medically refractory motor fluctuations received VY‐AADC01 bilaterally coadministered gadoteridol putamen magnetic resonance...
A bidirectional brain-computer interface that performs neurostimulation has been shown to improve seizure control in patients with refractory epilepsy, but the therapeutic mechanism is unknown.To investigate whether electrographic effects of responsive (RNS), identified electrocorticographic (ECOG) recordings from device, are associated patient outcomes.Retrospective review ECOG and accompanying clinical meta-data 11 consecutive focal epilepsy who were implanted a system between January 28,...
Deep brain stimulation electrode placement with interventional magnetic resonance imaging (MRI) has previously been reported using a commercially available skull-mounted aiming device (Medtronic Nexframe MR) and native MRI scanner software. This first-generation method technical limitations that are inherent to the hardware software used. A novel system (SurgiVision ClearPoint) consisting of an (SMARTFrame) developed specifically for MRI, including deep stimulation.To report series phantom...
Recent electrocorticography data have demonstrated excessive coupling of beta-phase to gamma-amplitude in primary motor cortex and that deep brain stimulation facilitates improvement by decreasing baseline phase-amplitude coupling. However, both the dynamic modulation during movement general cortical neurophysiology other disorders, such as essential tremor, are relatively unexplored. To clarify relationship these interactions oscillatory activity disease state, we recorded local field...