A5030082284- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Epilepsy research and treatment
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Impact of Light on Environment and Health
- Functional Brain Connectivity Studies
- Circadian rhythm and melatonin
- Human-Automation Interaction and Safety
- Sleep and related disorders
- Photoreceptor and optogenetics research
- Mathematical Biology Tumor Growth
- Music and Audio Processing
- Reproductive Biology and Fertility
- Radiomics and Machine Learning in Medical Imaging
- Sperm and Testicular Function
- Computational and Text Analysis Methods
- Ovarian function and disorders
- Autonomous Vehicle Technology and Safety
- Public Relations and Crisis Communication
- Genetic Syndromes and Imprinting
- Human Mobility and Location-Based Analysis
- Phonocardiography and Auscultation Techniques
- Mobile Crowdsensing and Crowdsourcing
Jinan University
2009-2025
Guangxi University
2022-2025
Massachusetts General Hospital
2021-2024
Harvard University
2022-2024
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2022
Shanghai Tongji Urban Planning and Design Institute
2017-2018
Tongji University
2017-2018
Tsinghua University
2018
Nanyang Technological University
2011-2018
Jilin Medical University
2014
Abstract We evaluated whether spike ripples, the combination of epileptiform spikes and provide a reliable improved biomarker for epileptogenic zone compared with other leading interictal biomarkers in multicentre, international study. first validated an automated ripple detector on intracranial EEG recordings. then applied this to subjects from four centres who subsequently underwent surgical resection known 1-year outcomes. rate cured after [International League Against Epilepsy Class 1...
Recently, corneal illuminance attracts much attention because it is closely related to important functions of indoor lighting. Especially, applying circadian light in the built environment places a challenging requirement on indirect illuminance. In this work, rule-of-thumb equations are proposed guide lighting design: (i) for artificial lighting, Ecor,avg = (Φ/C1) · ρ/(1−ρ′), where average at standing or sitting positions, Φ initial flux from luminaires, C1 constant comparable total room...
With the recent advances in photobiology research and light-emitting diode technology, lighting considering circadian effects potential health benefits attract much attention. In this study, we demonstrate that common practice of spectral optimisation light for high visual efficacy can potentially lead to very inefficient delivery stimulus, which contributes lack entrainment is likely happen indoor environments with only electric lighting. To optimise spectra white diodes efficacy, a...
Rolandic epilepsy (RE), the most common childhood focal syndrome, is characterized by a transient period of sleep-activated epileptiform activity in centrotemporal regions and variable cognitive deficits. Sleep spindles are prominent thalamocortical brain oscillations during sleep that have been mechanistically linked to sleep-dependent memory consolidation animal models healthy controls. decreased RE related epileptic encephalopathies. To further evaluate association between this...
Both the livestock and biomedical fields require a large supply of high-quality mature oocytes. However, in vitro maturation (IVM) process often leads to an accumulation reactive oxygen species (ROS), which can cause defects oocyte meiosis embryo development, ultimately compromising quality. Urolithin A (UA), known for its antioxidant properties, has not been thoroughly investigated potential mitigate negative effects oxidative stress during culturing oocytes, underlying mechanism is well...
The cross-regional interplay of slow oscillations, sleep spindles, and ripples during is believed to support systems memory consolidation but understudied in humans. Using a validated behavioral task intracranial neural recordings from orbitofrontal cortex, thalamus, hippocampus 19 epilepsy patients, we examined the sleep-oscillations their role consolidation. Orbitofrontal oscillations robustly modulate rhythms both within across regions. Most combinations oscillation rates predict...
Background: Sleep-dependent memory consolidation is supported by sleep spindles during stages 2 and 3 non-rapid eye movement sleep. Sleep sleep-dependent are both decreased in Rolandic epilepsy (RE). Non-invasive auditory stimulation evokes SOs SO-spindle complexes healthy adults but the impact on has been inconsistent. Objective: We investigated effects of SOs, complexes, children with RE controls. Methods: A prospective cross-over study was conducted control. Children completed two nap...
Angelman syndrome is a neurodevelopmental disorder caused by deficiency of the maternally inherited UBE3A gene in neurons. Antisense oligonucleotide therapies are under development to reinstate protein production. Non-invasive biomarkers detect target engagement and treatment response needed support clinical trials. Delta power measured scalp EEG reliable biomarker for but varies widely across individuals throughout development, making detection effect using single measurements challenging....
Considering the traditional concept of sex in China's official discourse and lack social support system for education China, burgeoning Internet knowledge community serves as an important forum unprepared Chinese young parents to discuss improve education. In this study, we conducted a structural topic modeling analysis discussions on Zhihu, biggest online China. We found attention towards are biased where basic sexual terminologies mentioned, but other topics such reproductive health,...
Epileptic encephalopathy with spike-wave activation in sleep (EE-SWAS) is a challenging neurodevelopmental disease characterized by abundant epileptiform spikes during non-rapid eye movement (NREM) accompanied cognitive dysfunction. The mechanism of dysfunction unknown, but treatment high-dose diazepam may improve symptoms. Spike rate does not predict response, disrupt spindles. We hypothesized that patients EE-SWAS: (1) and spindles would be anti-correlated, (2) increase decrease spikes,...
Critical aspects of motor learning and memory happen offline, during both wake sleep. When healthy young people learn a sequence task, most their performance improvement happens not while typing, but interleaved rest breaks. In contrast, the patients with dense amnesia due to hippocampal damage actually gets worse over breaks improves typing. These findings indicate that an intact hippocampus is necessary for offline wake, do specify its mechanism. Here, we studied epilepsy (n=17) undergoing...
Computer simulations based on a physiologically realistic tracer kinetic model with multiple pathways was used to provide insights the applicability and interpretation of tissue enhancement metrics such as maximum slope, peak area under curve, commonly in dynamic contrast-enhanced (DCE) MRI. Results show that physiological conditions could affect accuracy maximal slope method include high blood flow, increased variability flow within vasculature or low vascular volume. Interestingly, changes...
Smart wearable sensors are essential for continuous health-monitoring applications and detection accuracy of symptoms energy efficiency processing algorithms key challenges such devices. While several machine-learning-based the abnormal breath sounds reported in literature, they either too computationally expensive to implement into a device or inaccurate multi-class detection. In this paper, kernel-like minimum distance classifier (K-MDC) acoustic signal devices was proposed. The proposed...
Rolandic epilepsy (RE) is the most common focal, idiopathic, developmental epilepsy, characterized by a transient period of sleep-potentiated seizures and epileptiform discharges in inferior cortex during childhood. The cause RE remains unknown but converging evidence has identified abnormalities thalamocortical circuit. To better localize this disease, we evaluated functional structural connectivity sensory motor circuits separately symptomatic asymptomatic phases disease. We collected high...
Besides the study on examining facet joints of lumbar spine by ultrasound in normal population, there has not been any related report about so far. This was aimed to explore feasibility assessment lumber comparing measure values and degenerative joints, computed tomography (CT) joints. included 15 patients who had chronic low back pain because change vertebrae, 19 volunteers did have or lower limb. The (height [H] width [W]) were compared. And differentiation between (H W) CT also analyzed....
Abstract Background and Objectives Sleep spindles are prominent thalamocortical brain oscillations during sleep that have been mechanistically linked to sleep-dependent memory consolidation in animal models healthy controls. decreased Rolandic epilepsy related sleep-activated epileptic encephalopathies. We investigate the relationship between spindle deficits deficient dependent children with epilepsy. Methods In this prospective case-control study, were trained tested on a validated probe...
A distinct feature of the tumor vasculature is its tortuosity and irregular branching vessels, which can translate to a wider dispersion higher variability blood flow in tumor. To enable be assessed vivo by imaging, tracer kinetic model that accounts for developed use with dynamic contrast-enhanced (DCE) CT. The proposed adopts multiple-pathway approach allows quantification relative distribution, reflects vasculature. Monte Carlo simulation experiments were performed study possibility...
The current gold standard of Obstructive Sleep Apnea (OSA) diagnosis involves the use a Polysomnography (PSG) system which requires patient to stay in hospital for overnight recording. process is uncomfortable and it disturbs patient's sleep pattern. On other hand, well known that some acoustic features snoring sounds are good indicators presence OSA, variety OSA detection algorithms have been reported literature. Typically, these multiple relatively complex classifier, not ideal handling...
Epilepsy biomarkers from electroencephalogram recordings are routinely used to assess seizure risk and localization. Two widely adopted include: (i) interictal spikes, (ii) high frequency ripple oscillations. The combination of these two biomarkers, ripples co-occurring with spikes (spike ripples), has been proposed as an improved biomarker for the epileptogenic zone epileptogenicity in humans rodent models. Whether spike translate predict models is unknown. Further, recent evidence suggests...
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been widely applied to evaluate microcirculatory parameters in clinical settings. However, pre-clinical studies involving DCE-MRI of small animals remain challenging with the requirement for high spatial and temporal resolution quantitative tracer kinetic analysis. This study illustrates feasibility applying a (2 s) protocol liver mice by analyzing datasets dual-input two-compartment model. Phantom were performed validate T...