A5013499211- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Impact of Light on Environment and Health
- Gold and Silver Nanoparticles Synthesis and Applications
- Molecular Sensors and Ion Detection
- Electrochemical sensors and biosensors
- Building Energy and Comfort Optimization
- Advanced Nanomaterials in Catalysis
- Protein Interaction Studies and Fluorescence Analysis
- Circadian rhythm and melatonin
- Advanced Photocatalysis Techniques
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Luminescence and Fluorescent Materials
- DNA and Nucleic Acid Chemistry
- Color Science and Applications
- Analytical Chemistry and Sensors
- Electrochemical Analysis and Applications
- RNA Interference and Gene Delivery
- Signaling Pathways in Disease
- Nanoplatforms for cancer theranostics
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Legume Nitrogen Fixing Symbiosis
Zhejiang Chinese Medical University
2025
Hong Kong Polytechnic University
2021-2025
Air Force Medical University
2023-2025
South China Normal University
2024-2025
Wenzhou Medical University
2024-2025
First Affiliated Hospital of Wenzhou Medical University
2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024-2025
Wenzhou Institute of Technology Testing & Calibration
2025
Zhejiang University
2020-2025
Hubei University of Medicine
2024
CRISPR-Cas12a has been integrated with nanomaterial-based optical techniques, such as surface-enhanced Raman scattering (SERS), to formulate a powerful amplification-free nucleic acid detection system. However, nanomaterials impose steric hindrance limit the accessibility of narrow gaps (SERS hot spots) among nanoparticles (NPs) for producing significant change in signals after detection.
Surface-enhanced Raman scattering (SERS)-based biosensors are promising tools for virus nucleic acid detection. However, it remains challenging SERS-based using a sandwiching strategy to detect long-chain acids such as nucleocapsid (N) gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because the extension coupling distance (CD) between two tethered metallic nanostructures weakens electric field and SERS signals. Herein, we report magnetic-responsive substrate consisting...
Abstract The ongoing outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) pandemic has posed significant challenges in early viral diagnosis. Hence, it is urgently desirable to develop a rapid, inexpensive, and sensitive method aid point‐of‐care SARS‐CoV‐2 detection. In this work, we report highly sequence‐specific biosensor based on nanocomposites with aggregation‐induced emission luminogens (AIEgen)‐labeled oligonucleotide probes graphene oxide nanosheets (AIEgen@GO)...
Saccharides and peptides with markedly disparate stereochemical features serve as pivotal chiral molecular partners in living systems. The importance of glycosylation influencing glycopeptide self-assembly has been recognized. However, how different combinations saccharides influence the macroscopic hydrogel mechanics, fiber nanomechanics, asymmetric packing, thermodynamic changes during remains unknown. This study demonstrates that, following d-glycosylation peptides, resulting...
Recently, corneal illuminance attracts much attention because it is closely related to important functions of indoor lighting. Especially, applying circadian light in the built environment places a challenging requirement on indirect illuminance. In this work, rule-of-thumb equations are proposed guide lighting design: (i) for artificial lighting, Ecor,avg = (Φ/C1) · ρ/(1−ρ′), where average at standing or sitting positions, Φ initial flux from luminaires, C1 constant comparable total room...
The reduction of the cerebral glucose metabolism is closely related to activation NOD-like receptor protein 3 (NLRP3) inflammasome in Alzheimer's disease (AD); however, its underlying mechanism remains unclear. In this paper, 18F-flurodeoxyglucose positron emission tomography was used trace vivo, along with Western blotting and immunofluorescence assays examine expression distribution associated proteins. Glucose insulin tolerance tests were carried out detect resistance, Morris water maze...
Flexible surface-enhanced Raman spectroscopy (SERS) substrates have garnered more and attention due to their noninvasive sample collection ability. However, the improvement of SERS performance gradually reaches a bottleneck with numerous studies on exploration active materials. In this study, we constructed an Ag@TiO2@cotton substrate randomly distributed TiO2 nanocavities, which can generate strong coupling cavity mode, thus dramatically enhancing activities. The prepared demonstrate high...
Monitoring T lymphocyte differentiation is essential for understanding cell fate regulation and advancing adoptive immunotherapy. However, current biomarker analysis methods necessitate lysis, leading to source depletion. Intracellular pH (pHi) can be affected by the presence of lactic acid (LA), a metabolic mediator activity such as glycolysis during activation; therefore, it potentially good state. In this work, dual emitting enhancement-based nanoprobe, namely, AIEgen@F127-AptCD8, was...
Daily light-dark patterns incident on human eyes play an important role in maintaining a healthy circadian rhythm. The lack of daytime light indoor spaces could negatively impact the occupants' health and well-being long term. Therefore, applying lighting certain built environments is attractive. In this work, we introduce innovative methods for design investigate potential efficacy improvement by comparing these with traditional approaches. For spatial aspect, show that regular approach...
We herein provide a simple design strategy to improve the sensing specificity towards human serum albumin by incorporating nitrobenzene quencher into traditional polarity-sensitive probe in responding interference from blood lipids.
The hydroxyl substituent in flavonoids can cause the binding site to change from DS1 DS2 and restore ESIPT process of flavonoids, thereby leading a unique dual-emissive response towards human serum albumin.
The deadly Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak has become one of the most challenging pandemics in last century. Clinical diagnosis reports a high infection rate within large population and rapid mutation upon every individual infection. polymerase chain reaction been powerful gold standard molecular diagnostic technique over past few decades hence promising tool to detect SARS-CoV-2 nucleic acid sequences. However, it can be costly involved complicated...
Nanocellulose-based surface-enhanced Raman scattering (SERS) substrates have attracted extensive attention as sustainable, environmentally friendly, ultrasensitive sensing tools for trace detection of biological and chemical molecules. However, the development a facile, ecofriendly, low-cost, scalable fabrication method to prepare flexible nanocellulose-based SERS remains great challenge. Herein, renewable sustainable bacterial nanocellulose is used matrix material. The decorated with gold...