A5088000016- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Lanthanide and Transition Metal Complexes
- Protein Interaction Studies and Fluorescence Analysis
- Sulfur Compounds in Biology
- Antibiotics Pharmacokinetics and Efficacy
- Luminescence and Fluorescent Materials
- Electrochemical sensors and biosensors
- Biosensors and Analytical Detection
- Analytical Chemistry and Sensors
- Analytical chemistry methods development
- Advanced Biosensing Techniques and Applications
- Drug Transport and Resistance Mechanisms
- bioluminescence and chemiluminescence research
- Electron Spin Resonance Studies
- Synthesis and Biological Evaluation
- Pesticide Exposure and Toxicity
- Advanced Chemical Sensor Technologies
- Pharmacological Effects and Assays
- Electrochemical Analysis and Applications
- Pesticide Residue Analysis and Safety
- Advanced Nanomaterials in Catalysis
- Supramolecular Self-Assembly in Materials
- Alzheimer's disease research and treatments
- Peroxisome Proliferator-Activated Receptors
Shenzhen University
2019-2025
State Key Laboratory of Fine Chemicals
2024
South China University of Technology
2016-2020
Materials Science & Engineering
2020
Bioscience (China)
2016
The massive use of pesticides nowadays has led to serious consequences for the environment and public health. Fluorescence analytical methods are particularly advantageous with respect simplicity portability; however, currently available fluorescence (enzyme-based assays indicator displacement assays) poor universality only able detect few specific (e.g., organophosphorus). Making multiple flexible asymmetrical binding sites in albumin, we herein report a set multicolor albumin-based...
Two neutral merocyanine-based near-infrared fluorescent probes were for the first time developed through rational engineering of classical cationic cyanine scaffold IR-780 in vivo imaging amyloid-β plaques. In NIRF revealed that probe could penetrate blood-brain barrier and efficiently differentiate living transgenic wild-type mice.
The hydroxyl substituent in flavonoids can cause the binding site to change from DS1 DS2 and restore ESIPT process of flavonoids, thereby leading a unique dual-emissive response towards human serum albumin.
The first fluorescent sensor based on the indicator displacement assay (IDA) for on-site determination of etomidate.
Intermolecular proton transfer from a flavonol-based probe to the arginine (Arg222) in drug site 1 of human serum albumin triggers an unusual red-shifted ratiometric fluorescence response, which can be applied point-to-care diagnosis hypoalbuminemia.
A FA1-targeting albumin marker along with apixaban can form a co-binding complex albumin, resulting in readily discernible fluorescence color change.