A5062845557- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Click Chemistry and Applications
- Porphyrin and Phthalocyanine Chemistry
- Molecular Sensors and Ion Detection
- Photochromic and Fluorescence Chemistry
- Advanced Nanomaterials in Catalysis
- Cancer, Hypoxia, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Photoreceptor and optogenetics research
- Advanced Photocatalysis Techniques
- Photoacoustic and Ultrasonic Imaging
- Lanthanide and Transition Metal Complexes
- bioluminescence and chemiluminescence research
- Electrochemical sensors and biosensors
- Advanced Fluorescence Microscopy Techniques
- Luminescence Properties of Advanced Materials
- Crystallization and Solubility Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanoparticle-Based Drug Delivery
- Inflammasome and immune disorders
- Eicosanoids and Hypertension Pharmacology
- Vitamin C and Antioxidants Research
Shenzhen University
2023-2025
Materials Science & Engineering
2025
State Key Laboratory of Chemical Engineering
2025
Korea University
2020-2024
State Key Laboratory of Fine Chemicals
2024
Shenzhen Second People's Hospital
2024
Abbott (China)
2023
Dalian University
2016-2022
Dalian University of Technology
2016-2022
Xi'an Jiaotong University
2022
Hypoxia, a quite universal feature in most solid tumors, has been considered as the "Achilles' heel" of traditional photodynamic therapy (PDT) and substantially impairs overall therapeutic efficacy. Herein, we develop near-infrared (NIR) light-triggered molecular superoxide radical (O2-•) generator (ENBS-B) to surmount this intractable issue, also reveal its detailed O2-• action mechanism underlying antihypoxia effects, confirm application for vivo targeted hypoxic tumor ablation....
Tumor hypoxia has proven to be the major bottleneck of photodynamic therapy (PDT) clinical transformation. Different from traditional O2 delivery approaches, here we describe an innovative binary O2-economizer (PDOE) tactic reverse hypoxia-driven resistance by designing a superoxide radical (O2•–) generator targeting mitochondria respiration, termed SORgenTAM. This PDOE system is able block intracellular consumption and down-regulate HIF-1α expression, which successfully rescues cancer cells...
Strong oxygen dependence, poor tumor targeting, and limited treatment depth have been considered as the "Achilles' heels" facing clinical usage of photodynamic therapy (PDT). Different from common approaches, here, we propose an innovative tactic by using photon-initiated dyad cationic superoxide radical (O2–•) generator (ENBOS) featuring "0 + 1 > 1" amplification effect to simultaneously overcome these drawbacks. In particular, taking advantage Förster resonance energy transfer theory,...
It remains a considerable challenge to realize complete tumor suppression and avoid regrowth by rational design of photosensitizers (PSs) improve their photon utilization. In this Article, we provide molecular (Icy-NBF) based on the oxygen-content-regulated deactivation process excited states. presence overexpressed nitroreductase in hypoxic cancer cells, Icy-NBF is reduced converted into molecule with same skeleton (Icy-NH2), which PS under 808 nm light irradiation proceeds via different...
Structure-inherent targeting (SIT) agents are of particular importance for clinical precision medicine; however, there still exists a great lack SIT phototheranostics simultaneous cancer diagnosis and targeted photodynamic therapy (PDT). Herein, the first time, we propose "one-for-all" strategy by using Förster resonance energy transfer (FRET) mechanism to construct such omnipotent phototheranostics. Of note, this novel tactic can not only endow conventional sensitizers with highly effective...
Pyroptosis, a newly characterized form of immunogenic cell death, is attracting increasing attention as promising approach to cancer immunotherapy. However, biocompatible strategies activate pyroptosis remain rare. Here, we show that photocatalytic superoxide radical (O2-•) generator, NI-TA, triggers in cells. NI-TA was designed take advantage an intramolecular triplet-ground state splitting energy modulation approach. Detailed studies revealed the triggered by under conditions...
The transformational effect of photoredox catalytic chemistries has inspired new opportunities, enabling us to interrogate nature in ways that are not possible otherwise and unveil biotechnologies therapy diagnosis. However, the deployment artificial catalysis living systems remains challenging, mired by off-target risk safety concerns photocatalyst toxicity. Here, we present an appealing approach, namely conditionally activatable (ConAPC), as a proof concept design first ConAPC architecture...
ConspectusThe advent of photochemical techniques has revolutionized the landscape biology and medical sciences. Especially appealing in this context is photodynamic therapy (PDT), which a photon-initiated treatment modality that uses cytotoxic reactive oxygen species (ROS) to kill malignant cells. In past decade, PDT risen forefront cancer therapy. Its optical control enables noninvasive spatiotemporal manipulation process, its photoactive nature allows unique patterns avoid drug resistance...
Elucidating the underlying photochemical mechanisms of action (MoA) photodynamic therapy (PDT) may allow its efficacy to be improved and could set stage for development new classes PDT photosensitizers. Here, we provide evidence that "photoredox catalysis in cells," wherein key electron transport pathways are disrupted, constitute a general MoA associated with PDT. Taking cellular donor nicotinamide adenine dinucleotide as an example, have found well-known photosensitizers, such Rose Bengal,...
Abstract As an iron‐dependent lipid peroxidation (LPO) mediated cell death pathway, ferroptosis offers promises for anti‐tumor treatment. Photodynamic therapy (PDT) is ideal way to generate reactive oxygen species (ROS) LPO. However, the conventional PDT normally functions on subcellular organelles, such as endoplasmic reticulum, mitochondria, and lysosome, causing rapid before triggering ferroptosis. Herein, first droplet (Ld)‐targeting type I photosensitizer (PS) with enhanced superoxide...
Glioblastoma (GBM) poses a significant therapeutic challenge due to its invasive nature and limited drug penetration through the blood–brain barrier (BBB). In response, here we present an innovative biomimetic approach involving development of genetically engineered exosome nanocatalysts (Mn@Bi2Se3@RGE-Exos) for efficient GBM therapy via improving BBB enzyme-like catalytic activities. Interestingly, photothermally activatable multiple reactivity is observed in such nanosystem. Upon NIR-II...
Photon-controlled pyroptosis activation (PhotoPyro) is a promising technique for cancer immunotherapy due to its noninvasive nature, precise control, and ease of operation. Here, we report that biomolecular photoredox catalysis in cells might be an important mechanism underlying PhotoPyro. Our findings reveal the photocatalyst lutetium texaphyrin (
Biofilm-induced chronic bacterial infections represent a significant challenge in modern medicine due to their resistance conventional antibiotic treatments. Although photodynamic therapy (PDT) has emerged as promising antibiotic-free antibacterial strategy, the hypoxic condition within biofilms and lack of an effective local drug delivery system have limited clinical effectiveness photosensitizer (PS) agents. Herein, we propose type charge regulation-enhanced I PS-loaded hydrogel dressing...
Abstract Photodynamic therapy (PDT) using traditional type II photosensitizers (PSs) has been limited in hypoxic tumors due to excessive oxygen consumption. The conversion from into a less oxygen‐dependent I PDT pathway shown the potential combat tumors. Herein, design of heterodimeric PS, NBSSe , by conjugating widely used PS NBS and NBSe via molecular dimerization, achieving aggregation‐regulated efficient photodynamic for first time is reported. Electrochemistry characterizations...
Upconversion-based photon-initiated therapeutic modalities, photodynamic therapy (PDT) in particular, have shown significant clinical potential deep-seated tumor treatment.
Targeting is one of the most important strategies for enhancing efficacy cancer photothermal therapy (PTT) and reducing damage to surrounding normal tissues. Compared with traditional targeting approaches, active breast cells in PTT using chemotherapeutic drugs, such as tamoxifen (TAM), combination single-molecule photosensitizers has superior selectivity therapeutic effects. However, drug-targeting improved are not widely reported. Accordingly, herein, a near-infrared induced small-molecule...
An increased demand for iron is a hallmark of cancer cells and thought necessary to promote high cell proliferation, tumor progression metastasis. This makes metabolism an attractive therapeutic target. Unfortunately, current iron-based strategies often lack effectiveness can elicit off-target toxicities. We report here dual-therapeutic prodrug, DOXjade, that allows chelation chemo-photothermal therapy. prodrug takes advantage the clinically approved chelator deferasirox (ExJade®)...