A5036236233- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Genetic Neurodegenerative Diseases
- Obsessive-Compulsive Spectrum Disorders
- Advanced MRI Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Pain Mechanisms and Treatments
- Fetal and Pediatric Neurological Disorders
- Neuroscience and Neural Engineering
- Transcranial Magnetic Stimulation Studies
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Cerebral Palsy and Movement Disorders
- Psychosomatic Disorders and Their Treatments
- Sleep and Wakefulness Research
- Trigeminal Neuralgia and Treatments
- Medical Image Segmentation Techniques
- Cleft Lip and Palate Research
- Cell Image Analysis Techniques
- Spinal Dysraphism and Malformations
- Laser Applications in Dentistry and Medicine
- Intracranial Aneurysms: Treatment and Complications
- Orthodontics and Dentofacial Orthopedics
Universidade de São Paulo
2007-2022
Pain Management Institute
2022
Queen Square Radiosurgery Centre
2022
University of Würzburg
2010-2021
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2016-2019
University of Toronto
2018-2019
Sunnybrook Health Science Centre
2018-2019
Athinoula A. Martinos Center for Biomedical Imaging
2019
Charité - Universitätsmedizin Berlin
2019
Harvard University
2019
To report on the long-term outcomes of deep brain stimulation (DBS) thalamic ventral intermediate nucleus (VIM) in Parkinson disease (PD), essential tremor (ET), and dystonic tremor.One hundred fifty-nine patients with PD, ET, dystonia underwent VIM DBS due to refractory at Grenoble University Hospital. The primary outcome was a change scores 1 year after surgery latest follow-up (21 years). Secondary included relationship between score reduction over time active contact position. Tremor...
Abstract Frontal circuits play a critical role in motor, cognitive and affective processing, their dysfunction may result variety of brain disorders. However, exactly which frontal domains mediate (dys)functions remains largely elusive. We studied 534 deep stimulation electrodes implanted to treat four different By analyzing connections were modulated for optimal therapeutic response across these disorders, we segregated the cortex into that had become dysfunctional each them. Dysfunctional...
Abstract Introduction Sleep‐wake disturbances are a common and early feature in Alzheimer's disease (AD). The impact of tau pathology wake‐promoting neurons (WPNs) remains unclear. Methods We performed stereology postmortem brains from AD individuals healthy controls to identify quantitative differences morphological metrics WPNs. Progressive supranuclear palsy (PSP) corticobasal degeneration were included as disease‐specific controls. Results three nuclei studied accumulate considerable...
Aggressiveness has a high prevalence in psychiatric patients and is major health problem. Two brain areas involved the neural network of aggressive behavior are amygdala hypothalamus. While pharmacological treatments effective most patients, some do not properly respond to conventional therapies considered medically refractory. In this population, surgical procedures (ie, stereotactic lesions deep stimulation) have been performed an attempt improve symptomatology quality life. Clinical...
The cerebrocerebellum receives input from the cerebral cortex and projects to motor premotor cortices ventrolateral nucleus of thalamus via dentate (DN). Dentothalamocortical projections modulate activity contralateral primary (M1) are involved in movement planning. Acute ischemic injury cerebellar nuclei leads ataxia a loss physiologic excitatory inputs DN M1 cortex.1 However, chronic lesions have been associated with reemerging decrease intracortical inhibition (ICI) contralesional M1,...
Thalamotomies and pallidotomies were commonly performed before the deep brain stimulation (DBS) era. Although ablative procedures can lead to significant dystonia improvement, longer periods of analysis reveal disease progression functional deterioration. Today, same patients seek additional treatment possibilities.Four with generalized who previously had undergone bilateral pallidotomy came our service seeking because dystonic symptom progression. Bilateral subthalamic nucleus DBS...
There is an urgent need to identify individuals at risk of postural instability and gait difficulties, the resulting propensity for falls, in Parkinson's disease.Given known relationships between posture degeneration cholinergic pedunculopontine nucleus, we investigated whether metrics nucleus microstructural integrity hold independent utility predicting future difficulties they could be combined with other candidate biomarkers improve prognostication these symptoms.We used stereotactic...
Spinal cord injury (SCI) induces severe deficiencies in sensory-motor and autonomic functions has a significant negative impact on patients' quality of life. There is currently no systematic rehabilitation technique assuring recovery the neurological impairments caused by complete SCI. Here, we report clinical improvement group seven chronic SCI patients (six AIS A, one B) following 28-month, multi-step protocol that combined training with non-invasive brain-machine interfaces, visuo-tactile...
<h3>Importance</h3> Deep brain stimulation (DBS) has been investigated for treatment of morbid obesity with variable results. Patients Prader-Willi syndrome (PWS) present that is often difficult to treat. <h3>Objective</h3> To test the safety and study outcome DBS in patients PWS. <h3>Design, Setting, Participants</h3> This case series was conducted Hospital das Clínicas, University São Paulo, Brazil. Four genetically confirmed PWS presenting severe were included. <h3>Exposure</h3>...
Abstract Lateral hypothalamic area ( LHA ) local field potentials LFP s) were recorded in a Prader–Willi patient undergoing deep brain stimulation DBS for obesity. During hunger, exposure to food‐related cues induced an increase beta/low‐gamma activity. In contrast, recordings during satiety marked by prominent alpha rhythms. Based on these findings, we have delivered alpha‐frequency prior and food intake. Despite reporting early sensation of fullness, the continued crave food. This suggests...
Three-dimensional brain imaging through cutting-edge MRI technology allows assessment of physical and chemical tissue properties at sub-millimeter resolution. In order to improve understanding as part diagnostic tasks using images, other modalities obtain deep cerebral structures cytoarchitectural boundaries have been investigated. Under availability postmortem samples, the fusion histology supports more accurate description neuroanatomical since it preserves microscopic entities reveal fine...
Introduction We report our initial series of patients treated with radiosurgery to the Centromedian (CM) and Parafascicular (Pfc) Complex (CM-Pf) contralateral thalamus mainly for trigeminal neuralgia that had failed most known forms conventional treatments. The coordinates were co-registered a three-dimensional atlas in order have better comprehension isodose curves distribution. Methods A fully automated rotating gamma ray unit was used deliver high dose radiation (140 Gy) using 4-mm...
BACKGROUND AND OBJECTIVES: Deep brain stimulation (DBS) is a highly effective therapeutic intervention for managing neurological disorders, including Parkinson disease. However, conventional lead fixation methods, such as covering devices, often to complications, cranial deformities and electrode migration. The aim of our study was present novel technique that integrates n-butyl-2-cyanoacrylate adhesive with titanium “dog-bone” plate DBS fixation, enhance both esthetic functional outcomes....
Essential tremor (ET) can be disabling and frequently affects a patient's quality of life. Although many patients will benefit from pharmacologic therapy, up to 50% with ET present unsatisfactory control due drug adverse effects, comorbidities, or suboptimal response. Those may need additional surgical treatment. Bilateral deep brain stimulation (DBS) the thalamic Vim nucleus has been accepted as standard treatment, but results are limited by side effects such speech impairment, ataxia,...
In recent years, our group and others have reported multiple cases of consistent neurological recovery in people with spinal cord injury (SCI) following a protocol that integrates locomotion training brain machine interfaces (BMI). The primary objective this pilot study was to compare the outcomes (motor, tactile, nociception, proprioception, vibration) both an intensive assisted (LOC) neurorehabilitation integrating noninvasive brain-machine interface (L + BMI), virtual reality, tactile...
ABSTRACT Background The etiology of cervical dystonia is unknown. Cholinergic abnormalities have been identified in animal models and human imaging studies. Some cholinergic neuronal loss the striatum increased acetylcholinesterase activity pedunculopontine nucleus. Objectives objective this study was to determine presence putamen nucleus brain donors. Methods Formalin‐fixed tissues were obtained from 8 7 age‐matched control brains (controls). Pedunculopontine available only 6 5 controls....
Intractable aggressive behavior (iAB) is a devastating behavioral disorder that may affect psychiatric patients. These patients have reduced quality of life, are more challenging to treat as they impose high caregiver burden and require specialized care. Neuromodulatory interventions targeting the amygdala, key hub in circuitry (AB), provide symptom alleviation.To Report clinical imaging findings from case series iAB treated with bilateral amygdala ablation.This included 4 cases (3 males,...
Abstract Poststroke pain (PSP) is a heterogeneous term encompassing both central neuropathic (ie, poststroke [CPSP]) and nonneuropathic (CNNP) syndromes. Central classically related to damage in the lateral brainstem, posterior thalamus, parietoinsular areas, whereas role of white matter connecting these structures frequently ignored. In addition, relationship between stroke topography CNNP not completely understood. this study, we address issues comparing location CPSP group 35 patients...