A5003337168- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Neural and Behavioral Psychology Studies
- Obsessive-Compulsive Spectrum Disorders
- Neural dynamics and brain function
- Transcranial Magnetic Stimulation Studies
- Traumatic Brain Injury Research
- Ultrasound and Hyperthermia Applications
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Heart Rate Variability and Autonomic Control
- Memory and Neural Mechanisms
- Face Recognition and Perception
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Decision-Making and Behavioral Economics
- Electromagnetic Fields and Biological Effects
- Treatment of Major Depression
- Neuroscience and Neural Engineering
- Botulinum Toxin and Related Neurological Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Photoreceptor and optogenetics research
Tucson Medical Center
2024
Southern Arizona VA Health Care System
2024
Pima County Health Department
2022
New York State Psychiatric Institute
2019-2022
New York Psychoanalytic Society and Institute
2019-2022
University of Arizona
2012-2020
Stony Brook University
2011
Transcranial focused ultrasound (tFUS) is an emerging method for noninvasive neuromodulation akin to transcranial magnetic stimulation (TMS) and direct current (tDCS). tFUS offers several advantages over electromagnetic methods including high spatial resolution the ability reach deep brain targets. Here we describe two experiments assessing whether could modulate mood in healthy human volunteers by targeting right inferior frontal gyrus (rIFG), area implicated emotional regulation. In a...
Abstract The feedback negativity ( FN ) has been shown to reflect the binary evaluation of possible outcomes in a context‐dependent manner, but it is unclear whether context dependence based on global or local alternatives. A cued gambling task was used examine sensitive given trial, range across trials. On 50% trials, participants could break even lose money; remaining win even. Breaking an unfavorable outcome relative all possibilities current task, best Results indicated that breaking...
BackgroundDeep brain stimulation (DBS) of the thalamus can effectively reduce tics in severely affected patients with Tourette syndrome (TS). Its effect on cortical oscillatory activity is currently unknown.ObjectiveWe assessed whether DBS modulates beta at fronto-central electrodes. We explored concurrent EEG sources and probabilistic maps.MethodsResting state TS treated thalamic was recorded repeated DBS-on DBS-off states. A mixed linear model employed for statistical evaluation. were...
Abstract Frontal EEG alpha asymmetry provides a promising index of depression risk, yet very little is known about the neural sources asymmetry. To identify these sources, this study examined using distributed inverse solution: exact low resolution brain electromagnetic tomography (eLORETA). Findings implicated generator in lateral midfrontal regions that contributed to both surface and risk. Participants with any lifetime history depressive episodes were characterized by less left than...
Prior research has identified two resting EEG biomarkers with potential for predicting functional outcomes in depression: theta current density frontal brain regions (especially rostral anterior cingulate cortex) and alpha power over posterior scalp regions. As little is known about the discriminant convergent validity of these putative biomarkers, a thorough evaluation psychometric properties was conducted toward goal improving clinical utility markers. Resting 71-channel recorded from 35...
Closed-loop neuromodulation is presumed to be the logical evolution for improving effectiveness of deep brain stimulation (DBS) treatment protocols (Widge et al., 2018). Identifying symptom-relevant biomarkers that provide meaningful feedback stimulator devices an important initial step in this direction. This report demonstrates a technique assaying neural circuitry hypothesized contribute OCD and DBS outcomes. We computed phase-lag connectivity between LFPs EEGs thirteen...
Precision targeting of specific white matter bundles that traverse the subcallosal cingulate (SCC) has been linked to efficacy deep brain stimulation (DBS) for treatment resistant depression (TRD). Methods confirm optimal target engagement in this heterogenous region are now critical establish an objective protocol. As yet unexamined time-frequency features SCC evoked potential (SCC-EP), including spectral power and phase-clustering. We examined these features-evoked phase clustering-in a...
Symptoms of obsessive–compulsive disorder (OCD) are partly related to impaired cognitive control processes and theta modulations constitute an important electrophysiological marker for such as signaling negative performance feedback in a fronto-striatal network. Deep brain stimulation (DBS) targeting the anterior limb internal capsule (ALIC)/nucleus accumbens (NAc) shows clinical efficacy OCD, while exact influence on monitoring system remains largely unknown. Seventeen patients with...
Although conventional averaging across predefined frequency bands reduces the complexity of EEG functional connectivity (FC), it obscures identification resting-state brain networks (RSN) and impedes accurate estimation FC reliability. Extending prior work, we combined scalp current source density (CSD; spherical spline surface Laplacian) spectral-spatial PCA to identify components. Phase-based was estimated via debiased-weighted phase-locking index from CSD-transformed resting EEGs (71...
Abstract Objectives: This report examined theta-band neurodynamics for potential biomarkers of brain health in athletes with concussion. Methods: Participants included college-age contact/collision ( N =24) and without a history concussion =16) Study 1. 2 =10) changes over time athletes. There were two primary dependent variables: (1) phase-synchronization (e.g., functional connectivity) between medial right-lateral electrodes; (2) the within-subject correlation synchronization strength on...
Abstract Although conventional averaging across predefined frequency bands reduces the complexity of EEG functional connectivity (FC), it obscures identification resting-state brain networks (RSN) and impedes accurate estimation FC reliability. Extending prior work, we combined scalp current source density (CSD; spherical spline surface Laplacian) spectral-spatial PCA to identify components. Phase-based was estimated via debiased weighted phase-locking index from CSD-transformed resting EEGs...