A5032519886- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Sleep and related disorders
- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Neural dynamics and brain function
- Child and Adolescent Psychosocial and Emotional Development
- Sleep and Wakefulness Research
- Treatment of Major Depression
- EEG and Brain-Computer Interfaces
- Face Recognition and Perception
- Adolescent and Pediatric Healthcare
- Neuroscience of respiration and sleep
- Neuroscience and Music Perception
- Family and Patient Care in Intensive Care Units
- Neuroscience, Education and Cognitive Function
- Heart Rate Variability and Autonomic Control
- Digital Mental Health Interventions
- Obstructive Sleep Apnea Research
- Palliative Care and End-of-Life Issues
- Childhood Cancer Survivors' Quality of Life
- Neurobiology of Language and Bilingualism
- Decision-Making and Behavioral Economics
University of Michigan–Ann Arbor
2015-2024
Michigan United
2009-2023
Michigan Medicine
2015-2021
University Health System
2018-2021
Harvard University
2003-2011
Indiana University Bloomington
2010
William James College
2007
Bangor University
2004
National Center for PTSD
2004
Boston University
2004
Major depressive disorder (MDD) has been characterized by excessive default-network activation and connectivity with the subgenual cingulate. These hyper-connectivities are often interpreted as reflecting rumination, where MDDs perseverate on negative, self-referential thoughts. However, relationship between rumination not established. Furthermore, previous research examined how cingulate differs when individuals engaged in a task or not. The purpose of present study was to examine default...
Objective: Anomalies in error processing have been implicated the etiology and maintenance of major depressive disorder. In particular, depressed individuals exhibit heightened sensitivity to error-related information negative environmental cues, along with reduced responsivity positive reinforcers. The authors examined neural activation associated diagnosed without depression these processes modulation by monetary task contingencies. Method: negativity positivity components event-related...
Some individuals have very specific and differentiated emotional experiences, such as anger, shame, excitement, happiness, whereas others more general affective experiences of pleasure or discomfort that are not highly differentiated. Considering with major depressive disorder (MDD) cognitive deficits for negative information, we predicted people MDD would less than healthy people. To test this hypothesis, assessed participants’ using a 7-day experience-sampling protocol. Depression was...
Major depressive disorder (MDD) remains challenging to treat. Although several clinical and demographic variables have been found predict poor antidepressant response, these markers not robustly replicated warrant implementation in care. Increased pretreatment rostral anterior cingulate cortex (rACC) theta activity has linked better outcomes. However, no prior study evaluated whether this marker incremental predictive validity over measures.To determine increased rACC would symptom...
Abstract Background Major depressive disorder (MDD) is a highly heterogeneous condition in terms of symptom presentation and, likely, underlying pathophysiology. Accordingly, it possible that only certain individuals with MDD are well-suited to antidepressants. A potentially fruitful approach parsing this heterogeneity focus on promising endophenotypes depression, such as neuroticism, anhedonia, and cognitive control deficits. Methods Within an 8-week multisite trial sertraline v. placebo...
Although analyzing negative experiences leads to physical and mental health benefits among healthy populations, when people with depression engage in this process on their own they often ruminate feel worse. Here we examine whether it is possible for adults analyze feelings adaptively if adopt a self-distanced perspective. We examined issue by randomly assigning depressed nondepressed surrounding depressing life experience from either or self-immersed perspective then the implications of...
Clinical research suggests that individuals with major depressive disorder (MDD) are cognitively inflexible, exhibiting ruminative, rigid, and automatic thoughts within a negative schema. However, existing neuropsychological on cognitive flexibility in this population has not employed emotional stimuli. Because the performance of MDD is modulated when stimuli used, study investigates impact through novel modification Wisconsin Card Sorting Test. Controls were less flexible positive relative...
Dysfunctional negative thoughts about the self have long been hypothesized to reflect mood-independent cognitive vulnerability for major depressive disorder. These are believed be predominantly automatic, in that they involuntary and hard inhibit. However, existing empirical evidence provides limited support this theory, instead emphasizing role of intentional ruminative (i.e., effortful) thoughts. To help clarify theoretical controversy investigate biased processing emotional self-referent...
Accurately perceiving self-referential social signals, particularly eye contact, is critical to adaptation. Schizophrenia often accompanied by deficits in cognition, but it unclear whether this includes gaze discrimination deficits. This study investigated eye-contact perception preserved or impaired and if related symptoms broader socioemotional functioning schizophrenia. Twenty-six participants with schizophrenia (SCZ) 23 healthy controls (HC) made judgments for faces varying direction...
Background Depression is characterized by poor executive function, but – counterintuitively in some studies, it has been associated with highly accurate performance on certain cognitively demanding tasks. The psychological mechanisms responsible for this paradoxical finding are unclear. To address issue, we applied a drift diffusion model (DDM) to flanker task data from depressed and healthy adults participating the multi-site Establishing Moderators Biosignatures of Antidepressant Response...
The high comorbidity of depression and anxiety is well established empirically but not understood conceptually, in terms either psychological or biological mechanisms. A neuropsychological model regional brain activity emotion provides contrasting hypotheses for anxiety, with associated a relative decrease increase right-posterior activity. These received support comparison individuals diagnosed community controls, also separate study nonpatients administered measure perceptual asymmetry....
Evidence of a right-posterior brain anomaly was found in study 19 individuals with major depression and 15 controls. Participants performed recognition-memory task involving positive, neutral, negative face word stimuli. Scalp wave topography suggested region-specific the depressed group. Individuals demonstrated reduction N200 component event-related potential to faces not words. Furthermore, results indicate that regional is specific positive facial Findings are interpreted light model...