A5059970829- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Treatment of Major Depression
- Personality Disorders and Psychopathology
- Child and Adolescent Psychosocial and Emotional Development
- Psychotherapy Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Psychosomatic Disorders and Their Treatments
- Neural and Behavioral Psychology Studies
- Electroconvulsive Therapy Studies
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Face Recognition and Perception
- Obsessive-Compulsive Spectrum Disorders
- Digital Mental Health Interventions
- Mental Health Treatment and Access
- Counseling, Therapy, and Family Dynamics
- Evolutionary Psychology and Human Behavior
- Health Systems, Economic Evaluations, Quality of Life
- Posttraumatic Stress Disorder Research
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Heart Rate Variability and Autonomic Control
The Ohio State University
2021-2024
University of Pittsburgh
2012-2021
University of Pittsburgh Medical Center
2014-2020
University of Pennsylvania
2008-2010
Background Advances in personalized medicine require the identification of variables that predict differential response to treatments as well development and refinement methods transform predictive information into actionable recommendations. Objective To illustrate test a new method for integrating aid treatment selection, using data from randomized comparison. Method Data trial antidepressant medications (N = 104) versus cognitive behavioral therapy 50) Major Depressive Disorder were used...
A recent randomized controlled trial found nearly equivalent response rates for antidepressant medications and cognitive therapy in a sample of moderate to severely depressed outpatients. In this article, the authors seek identify variables that were associated with across both treatments as well predicted superior one treatment over other. The consisted 180 outpatients: 60 whom randomly assigned therapy; 120 medications. Treatment was provided 16 weeks. Chronic depression, older age, lower...
Abstract Background Major depressive disorder (MDD) is a highly heterogeneous condition in terms of symptom presentation and, likely, underlying pathophysiology. Accordingly, it possible that only certain individuals with MDD are well-suited to antidepressants. A potentially fruitful approach parsing this heterogeneity focus on promising endophenotypes depression, such as neuroticism, anhedonia, and cognitive control deficits. Methods Within an 8-week multisite trial sertraline v. placebo...
Abstract Background Neuroticism is associated with the onset and maintenance of a number mental health conditions, as well deleterious outcomes (e.g. physical problems, higher divorce rates, lost productivity, increased treatment seeking); thus, consideration whether this trait can be addressed in warranted. To date, outcome research has yielded mixed results regarding neuroticism's responsiveness to treatment, perhaps due fact that study interventions are typically designed target disorder...
There is conflicting evidence about comorbid personality pathology in depression treatments.To test the effects of antidepressant drugs and cognitive therapy people with distinguished by presence or absence disorder.Random assignment 180 out-patients to 16 weeks medication therapy. Random responders continued placebo, comparison over a 12-month period.Personality disorder status led differential response at weeks; 66% v. 44% (antidepressants respectively) for disorder, 49% 70% without...
Objective: We identify difficulties researchers encounter in psychotherapy process-outcome investigations, and we describe several limitations of the popular "variance accounted for" approach to understanding effects psychotherapy. Methods & Results: Using data simulations, show how expected correlation between an excellent measure therapy quality outcome would be surprisingly small (approximately .25) under conditions likely common research. Even when modeled designed increase likelihood...
High trait impulsive sensation seeking (ISS) is common in 18-25-year olds, and associated with risky decision-making deleterious outcomes. We examined relationships among: activity reward regions previously ISS during an ISS-relevant context, uncertain expectancy (RE), using fMRI; impulsivity sensation-seeking subcomponents; 100, transdiagnostically recruited olds. ISS, anhedonia, anxiety, depression mania were measured self-report scales; clinician-administered scales also assessed the...
Background Prior studies of adult post-traumatic stress disorder (PTSD) suggest abnormal functioning prefrontal and limbic regions. Cumulative childhood trauma exposures are major risk factors for developing PTSD, yet their contribution to neural dysfunction in PTSD remains poorly understood. This study aimed examine the correlates exposure symptoms (PTSS) within a single model. Method Medication-free male combat veterans ( n = 28, average age 26.6 years) with wide range PTSS were recruited...
Anxiety and depression co-occur; the neural substrates of shared unique components these symptoms are not understood. Given emotional alterations in internalizing disorders, we hypothesized that function regions associated with emotion processing/regulation, including anterior cingulate cortex (ACC), amygdala fusiform gyrus (FG), would differentiate symptoms. Forty-three adults completed an functional magnetic resonance imaging task Hamilton Depression Scales. We transformed scales to...
Objectives It can be clinically difficult to distinguish depressed individuals with bipolar disorder ( BD ) and major depressive MDD ). To examine potential biomarkers of difference between the two disorders, current study examined differences in functioning emotion‐processing neural regions during a dynamic emotional faces task. Methods During functional magnetic resonance imaging, healthy control adults HC (n = 29) 30) 22) performed an implicit emotional‐faces task which they identified...
Pediatric disorders characterized by behavioral and emotional dysregulation pose diagnostic treatment challenges because of high comorbidity, suggesting that they may be better conceptualized dimensionally rather than categorically. Identifying neuroimaging measures associated with in youth inform understanding underlying dimensional vs disorder-specific pathophysiologic features.To identify, a large cohort behaviorally emotionally dysregulated youth, (1) are pathologic dimensions...
Depressed patients with comorbid personality pathology may fare worse in treatment for depression than those without this additional pathology, and be associated superior response one form of relative to another, though recent findings have been mixed. We aimed evaluate the effect on time remission randomly assigned 1 2 strategies determine whether moderated assignment outcome.Individuals undergoing an episode unipolar major (n = 275) received interpersonal psychotherapy (Klerman, Weissman,...
Technological advances in neuroimaging have enabled researchers to examine,
This study examines the structure of Personality Belief Questionnaire (PBQ), a self-report instrument designed to assess dysfunctional beliefs associated with personality pathology, as proposed by cognitive theory dysfunction.The PBQ was examined using exploratory factor analysis (EFA) responses from 438 depressed out-patients, and confirmatory (CFA) 683 treatment-seeking psychiatric out-patients. All participants were assessed for disorder (PD) standard clinical interview. The validity...