A5010294016- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- Mental Health Research Topics
- Tryptophan and brain disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Psychotherapy Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Attention Deficit Hyperactivity Disorder
- Pharmacogenetics and Drug Metabolism
- Mental Health Treatment and Access
- Maternal Mental Health During Pregnancy and Postpartum
- Opioid Use Disorder Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Personality Disorders and Psychopathology
- Suicide and Self-Harm Studies
- Eating Disorders and Behaviors
- Sleep and related disorders
- Neuroscience and Neuropharmacology Research
- Mental Health and Psychiatry
- Genetics and Neurodevelopmental Disorders
University of Alabama at Birmingham
2016-2025
Swedish Civil Contingencies Agency
2024
MJC2 (United Kingdom)
2024
Adventist Health Simi Valley
2024
Myriad Genetics
2021
McLean Hospital
2021
University of Alabama
2014-2020
Vanderbilt University
2006-2019
The University of Texas Southwestern Medical Center
2009-2019
University of Pennsylvania
2009-2019
<h3>Background</h3> There is substantial evidence that antidepressant medications treat moderate to severe depression effectively, but there less data on cognitive therapy’s effects in this population. <h3>Objective</h3> To compare the efficacy of with therapy a placebo-controlled trial. <h3>Design</h3> Random assignment one following: 16 weeks (n = 120), 60), or 8 pill placebo 60). <h3>Setting</h3> Research clinics at University Pennsylvania, Philadelphia, and Vanderbilt University,...
About one-third of patients with depression fail to achieve remission despite treatment multiple antidepressants. This study compared the efficacy and safety switching treatment-resistant from an ineffective antidepressant flexibly dosed esketamine nasal spray plus a newly initiated or (active comparator) placebo spray.This was phase 3, double-blind, active-controlled, multicenter conducted at 39 outpatient referral centers. The enrolled adults moderate severe nonpsychotic history...
Background: Antidepressant medication prevents the return of depressive symptoms, but only as long treatment is continued.Objectives: To determine whether cognitive therapy (CT) has an enduring effect and to compare this against produced by continued antidepressant medication.Design: Patients who responded CT in a randomized controlled trial were withdrawn from compared during 12-month period with responders had been randomly assigned either continuation or placebo withdrawal.Patients...
Anhedonia is a core feature of major depressive disorder (MDD), but the precise nature anhedonic symptoms unknown. Whereas anhedonia has traditionally been viewed as deficit in experience pleasure, more recent evidence suggests that reduced anticipation and motivation may also be this symptom. Here, we provide data from study MDD patients healthy controls using translational measure reward motivation, Effort Expenditure for Rewards Task (EEfRT or "effort"). This task offers subjects series...
Treatment-resistant depression is a significant public health concern; drug switching or augmentation often produce limited results. The authors hypothesized that fluoxetine could be augmented with olanzapine to successfully treat resistant depression.An 8-week double-blind study was conducted 28 patients who were diagnosed recurrent, nonbipolar, treatment-resistant without psychotic features. Subjects randomly assigned one of three groups: plus placebo, fluoxetine.Fluoxetine monotherapy...
<h3>Context</h3> High neuroticism is a personality risk factor that reflects much of the genetic vulnerability to major depressive disorder (MDD), and low extraversion may increase as well. Both have been linked serotonin system. <h3>Objectives</h3> To test whether patients with MDD taking selective reuptake inhibitors (SSRIs) report greater changes in than receiving inert placebo, examine state effect hypothesis self-reported change during SSRI treatment merely depression-related...
Objective: Two antidepressant medication combinations were compared with selective serotonin reuptake inhibitor monotherapy to determine whether either combination produced a higher remission rate in first-step acute-phase (12 weeks) and long-term (7 months) treatment. Method: The single-blind, prospective, randomized trial enrolled 665 outpatients at six primary nine psychiatric care sites. Participants had least moderately severe nonpsychotic chronic and/or recurrent major depressive...
A recent randomized controlled trial found nearly equivalent response rates for antidepressant medications and cognitive therapy in a sample of moderate to severely depressed outpatients. In this article, the authors seek identify variables that were associated with across both treatments as well predicted superior one treatment over other. The consisted 180 outpatients: 60 whom randomly assigned therapy; 120 medications. Treatment was provided 16 weeks. Chronic depression, older age, lower...
Treatment-resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD demonstrated predictive utility in terms clinical decision-making outcomes does not currently exist. Instead, a plethora definitions have been proposed, which vary significantly their conceptual framework. The absence hampers precise estimates the prevalence TRD, also belies efforts to identify risk factors, prevention opportunities, effective...
Since Emil Kraepelin's conceptualization of endogenous psychoses as dementia praecox and manic depression, the separation between primary psychotic disorders affective has been much debated. We conducted a systematic review case-control studies contrasting magnetic resonance imaging in schizophrenia bipolar disorder. A literature search PubMed published January 2005 December 2016 was conducted, 50 structural, 29 functional, 7 spectroscopy, 8 combined genetic were deemed eligible for review....
Antidepressant medication (ADM) is efficacious in the treatment of depression, but not all patients achieve remission and fewer still recovery with ADM alone.To determine effects combining cognitive therapy (CT) vs alone on major depressive disorder (MDD).A total 452 adult outpatients chronic or recurrent MDD participated a trial conducted research clinics at 3 university medical centers United States. The were randomly assigned to CT combined treatment. Treatment was continued for up 42...